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Family Report for: Glutactin


Family Glutactin
Block C
Parent Family : Non-catalytic_C

Insect specific protein. Glutactin has a signal peptide and an amino domain of greater than 500 residues that strongly resembles acetylcholine esterases and other serine esterases, but lacks the catalytically critical serine residue. It is located at embryonic basement membranes, particularly to the sequentially invaginated envelope of the central nervous system, muscle apodemes and dorsal median cell processes. Ectopic expression of Glutactin inhibits synapse formation by motor neurons that normally innervate M12 muscle. Only the N-terminal part of Glutactin is a member of the alpha/beta hydrolase family. The C-terminal part is not included in ESTHER

IPR002018 (Carboxylesterase, type B)
PF00135 (COesterase)
no EC number

Peptide in
Nucleotide in
Alignment with Multalin
|Text only/graphic display
Seed alignment with MAFFT
|No colour/coloured with Mview
Alignment with MAFFT
|No colour/coloured with Mview
|Graphical display, obtained with the dnd file produced by Clustalw

1 more
    Title: Wnt4 is a local repulsive cue that determines synaptic target specificity.
    Inaki M, Yoshikawa S, Thomas JB, Aburatani H, Nose A
    Ref: Current Biology, 17:1574, 2007 : PubMed


    Title: The structure-function relationships in Drosophila neurotactin show that cholinesterasic domains may have adhesive properties
    Darboux I, Barthalay Y, Piovant M, Hipeau-Jacquotte R
    Ref: EMBO Journal, 15:4835, 1996 : PubMed


    Title: Glutactin, a novel Drosophila basement membrane-related glycoprotein with sequence similarity to serine esterases
    Olson PF, Fessler LI, Nelson RE, Sterne RE, Campbell AG, Fessler JH
    Ref: EMBO Journal, 9:1219, 1990 : PubMed


Other Papers

No structure scheme yet for this family

No Structure yet in this family

Genes Proteins in Glutactin family (49)

Fragments of genes in Glutactin family (7)

No Substrate

No Inhibitor

Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
For technical information about these pages see:
ESTHER Home Page and ACEDB Home Page
AcePerl Lincoln Stein Home Page

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