Haloalkane_dehalogenase-HLD1
Relationship
Comment
Haloalkane dehalogenases (HLDs) are enzymes that catalyze the cleavage of carbon halogen bonds by a hydrolytic mechanism. The catalytic triad consists of the key nucleophile (Asp) the general base (His) and a catalytic acid (Asp or Glu). HLD where subdivided in three subfamily (Chovancova et al.) according to their substrate specificity and position of active site residues. Class one HLD1 (HLD-I) has catalytic triad Asp-His-Asp and halide-strabilizing residues Trp-Trp. Class two HLDII (HLD-II) has catalytic triad Asp-His-Glu and halide-stabilizing residues Asn-Trp. Class three HLDIII (HLD-III) has catalytic triad Asp-His-Asp and halide-strabilizing residues Asn-Trp. Also the reaction performed is different, the Renilla reniformis luciferase belongs to this family. In ESTHER as in HAMAP database class I and III are merged as they are close. OleB from bacterial hydrocarbon biosynthesis is a -lactone decarboxylase (Christenson et al.2017)Database
Interpro : IPR023489 Haloalkane dehalogenase, subfamily 1
PIRSF : No PIRSF
Pdoc : No Pdoc
Pfam : PF00561 Abhydrolase_1
Prints : No Print
EC Number : 3.8.1.5
References (15)
| Title : Exploring the challenges of computational enzyme design by rebuilding the active site of a dehalogenase - Jindal_2019_Proc.Natl.Acad.Sci.U.S.A_116_389 |
| Author(s) : Jindal G , Slanska K , Kolev V , Damborsky J , Prokop Z , Warshel A |
| Ref : Proc Natl Acad Sci U S A , 116 :389 , 2019 |
| Abstract : Jindal_2019_Proc.Natl.Acad.Sci.U.S.A_116_389 |
| ESTHER : Jindal_2019_Proc.Natl.Acad.Sci.U.S.A_116_389 |
| PubMedSearch : Jindal_2019_Proc.Natl.Acad.Sci.U.S.A_116_389 |
| PubMedID: 30587585 |
| Gene_locus related to this paper: xanau-halo1 |
| Title : OleB from Bacterial Hydrocarbon Biosynthesis Is a beta-Lactone Decarboxylase That Shares Key Features with Haloalkane Dehalogenases - Christenson_2017_Biochemistry_56_5278 |
| Author(s) : Christenson JK , Robinson SL , Engel TA , Richman JE , Kim AN , Wackett LP |
| Ref : Biochemistry , 56 :5278 , 2017 |
| Abstract : Christenson_2017_Biochemistry_56_5278 |
| ESTHER : Christenson_2017_Biochemistry_56_5278 |
| PubMedSearch : Christenson_2017_Biochemistry_56_5278 |
| PubMedID: 28872321 |
| Gene_locus related to this paper: miclc-OleB , xancp-OleB |
| Title : Biochemical characterization of two haloalkane dehalogenases: DccA from Caulobacter crescentus and DsaA from Saccharomonospora azurea - Carlucci_2016_Protein.Sci_25_877 |
| Author(s) : Carlucci L , Zhou E , Malashkevich VN , Almo SC , Mundorff EC |
| Ref : Protein Science , 25 :877 , 2016 |
| Abstract : Carlucci_2016_Protein.Sci_25_877 |
| ESTHER : Carlucci_2016_Protein.Sci_25_877 |
| PubMedSearch : Carlucci_2016_Protein.Sci_25_877 |
| PubMedID: 26833751 |
| Gene_locus related to this paper: caucr-CC1175 |
| Title : Properties and biotechnological applications of natural and engineered haloalkane dehalogenases - Nagata_2015_Appl.Microbiol.Biotechnol_99_9865 |
| Author(s) : Nagata Y , Ohtsubo Y , Tsuda M |
| Ref : Applied Microbiology & Biotechnology , 99 :9865 , 2015 |
| Abstract : Nagata_2015_Appl.Microbiol.Biotechnol_99_9865 |
| ESTHER : Nagata_2015_Appl.Microbiol.Biotechnol_99_9865 |
| PubMedSearch : Nagata_2015_Appl.Microbiol.Biotechnol_99_9865 |
| PubMedID: 26373728 |
| Title : Biochemical and biophysical characterisation of haloalkane dehalogenases DmrA and DmrB in Mycobacterium strain JS60 and their role in growth on haloalkanes - Fung_2015_Mol.Microbiol_97_439 |
| Author(s) : Fung HK , Gadd MS , Drury TA , Cheung S , Guss JM , Coleman NV , Matthews JM |
| Ref : Molecular Microbiology , 97 :439 , 2015 |
| Abstract : Fung_2015_Mol.Microbiol_97_439 |
| ESTHER : Fung_2015_Mol.Microbiol_97_439 |
| PubMedSearch : Fung_2015_Mol.Microbiol_97_439 |
| PubMedID: 25899475 |
| Gene_locus related to this paper: mycrh-g4i2j6 |
| Title : Cloning, functional expression, biochemical characterization, and structural analysis of a haloalkane dehalogenase from Plesiocystis pacifica SIR-1 - Hesseler_2011_Appl.Microbiol.Biotechnol_91_1049 |
| Author(s) : Hesseler M , Bogdanovic X , Hidalgo A , Berenguer J , Palm GJ , Hinrichs W , Bornscheuer UT |
| Ref : Applied Microbiology & Biotechnology , 91 :1049 , 2011 |
| Abstract : Hesseler_2011_Appl.Microbiol.Biotechnol_91_1049 |
| ESTHER : Hesseler_2011_Appl.Microbiol.Biotechnol_91_1049 |
| PubMedSearch : Hesseler_2011_Appl.Microbiol.Biotechnol_91_1049 |
| PubMedID: 21603934 |
| Gene_locus related to this paper: 9delt-a6g7b1 |
| Title : Substrate specificity of haloalkane dehalogenases - Koudelakova_2011_Biochem.J_435_345 |
| Author(s) : Koudelakova T , Chovancova E , Brezovsky J , Monincova M , Fortova A , Jarkovsky J , Damborsky J |
| Ref : Biochemical Journal , 435 :345 , 2011 |
| Abstract : Koudelakova_2011_Biochem.J_435_345 |
| ESTHER : Koudelakova_2011_Biochem.J_435_345 |
| PubMedSearch : Koudelakova_2011_Biochem.J_435_345 |
| PubMedID: 21294712 |
| Gene_locus related to this paper: agrtu-DHAA , brael-e2rv62 , braja-dhaa , myctu-linb , myctu-Rv1833c , rhoba-DHLA , rhoso-halo1 , sphpi-linb , xanau-halo1 |
| Title : Phylogenetic analysis of haloalkane dehalogenases - Chovancova_2007_Proteins_67_305 |
| Author(s) : Chovancova E , Kosinski J , Bujnicki JM , Damborsky J |
| Ref : Proteins , 67 :305 , 2007 |
| Abstract : Chovancova_2007_Proteins_67_305 |
| ESTHER : Chovancova_2007_Proteins_67_305 |
| PubMedSearch : Chovancova_2007_Proteins_67_305 |
| PubMedID: 17295320 |
| Title : Evolving haloalkane dehalogenases - Janssen_2004_Curr.Opin.Chem.Biol_8_150 |
| Author(s) : Janssen DB |
| Ref : Curr Opin Chemical Biology , 8 :150 , 2004 |
| Abstract : Janssen_2004_Curr.Opin.Chem.Biol_8_150 |
| ESTHER : Janssen_2004_Curr.Opin.Chem.Biol_8_150 |
| PubMedSearch : Janssen_2004_Curr.Opin.Chem.Biol_8_150 |
| PubMedID: 15062775 |
| Title : Crystallographic and kinetic evidence of a collision complex formed during halide import in haloalkane dehalogenase - Pikkemaat_1999_Biochemistry_38_12052 |
| Author(s) : Pikkemaat MG , Ridder IS , Rozeboom HJ , Kalk KH , Dijkstra BW , Janssen DB |
| Ref : Biochemistry , 38 :12052 , 1999 |
| Abstract : Pikkemaat_1999_Biochemistry_38_12052 |
| ESTHER : Pikkemaat_1999_Biochemistry_38_12052 |
| PubMedSearch : Pikkemaat_1999_Biochemistry_38_12052 |
| PubMedID: 10508409 |
| Gene_locus related to this paper: xanau-halo1 |
| Title : Repositioning the catalytic triad aspartic acid of haloalkane dehalogenase: effects on stability, kinetics, and structure - Krooshof_1997_Biochemistry_36_9571 |
| Author(s) : Krooshof GH , Kwant EM , Damborsky J , Koca J , Janssen DB |
| Ref : Biochemistry , 36 :9571 , 1997 |
| Abstract : Krooshof_1997_Biochemistry_36_9571 |
| ESTHER : Krooshof_1997_Biochemistry_36_9571 |
| PubMedSearch : Krooshof_1997_Biochemistry_36_9571 |
| PubMedID: 9236003 |
| Title : Kinetic characterization and X-ray structure of a mutant of haloalkane dehalogenase with higher catalytic activity and modified substrate range - Schanstra_1996_Biochemistry_35_13186 |
| Author(s) : Schanstra JP , Ridder IS , Heimeriks GJ , Rink R , Poelarends GJ , Kalk KH , Dijkstra BW , Janssen DB |
| Ref : Biochemistry , 35 :13186 , 1996 |
| Abstract : Schanstra_1996_Biochemistry_35_13186 |
| ESTHER : Schanstra_1996_Biochemistry_35_13186 |
| PubMedSearch : Schanstra_1996_Biochemistry_35_13186 |
| PubMedID: 8855957 |
| Gene_locus related to this paper: xanau-halo1 |
| Title : Crystallographic analysis of the catalytic mechanism of haloalkane dehalogenase - Verschueren_1993_Nature_363_693 |
| Author(s) : Verschueren KH , Seljee F , Rozeboom HJ , Kalk KH , Dijkstra BW |
| Ref : Nature , 363 :693 , 1993 |
| Abstract : Verschueren_1993_Nature_363_693 |
| ESTHER : Verschueren_1993_Nature_363_693 |
| PubMedSearch : Verschueren_1993_Nature_363_693 |
| PubMedID: 8515812 |
| Gene_locus related to this paper: xanau-halo1 |
| Title : Crystallographic and fluorescence studies of the interaction of haloalkane dehalogenase with halide ions. Studies with halide compounds reveal a halide binding site in the active site - Verschueren_1993_Biochemistry_32_9031 |
| Author(s) : Verschueren KH , Kingma J , Rozeboom HJ , Kalk KH , Janssen DB , Dijkstra BW |
| Ref : Biochemistry , 32 :9031 , 1993 |
| Abstract : Verschueren_1993_Biochemistry_32_9031 |
| ESTHER : Verschueren_1993_Biochemistry_32_9031 |
| PubMedSearch : Verschueren_1993_Biochemistry_32_9031 |
| PubMedID: 8369276 |
| Gene_locus related to this paper: xanau-halo1 |
| Title : Crystal structure of haloalkane dehalogenase: an enzyme to detoxify halogenated alkanes - Franken_1991_EMBO.J_10_1297 |
| Author(s) : Franken SM , Rozeboom HJ , Kalk KH , Dijkstra BW |
| Ref : EMBO Journal , 10 :1297 , 1991 |
| Abstract : Franken_1991_EMBO.J_10_1297 |
| ESTHER : Franken_1991_EMBO.J_10_1297 |
| PubMedSearch : Franken_1991_EMBO.J_10_1297 |
| PubMedID: 2026135 |
| Gene_locus related to this paper: xanau-halo1 |
Structures (25)
Genes Proteins in Haloalkane_dehalogenase-HLD1 family (142)
Fragments of genes in Haloalkane_dehalogenase-HLD1 family (1)
Structures in Haloalkane_dehalogenase-HLD1 family (25)Substrates in Haloalkane_dehalogenase-HLD1 family (33)
No Inhibitor