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Kynurenine-formamidase

Relationship

Family: Kynurenine-formamidase

Block: H

Parent Family: No family

Comment

Kynurenine formamidase (EC:3.5.1.9) catalyses the hydrolysis of N-formyl-L-kynurenine to L-kynurenine, the second step in the kynurenine pathway of tryptophan degradation. It is required for elimination of toxic metabolites

Database

Interpro : IPR027519 Kynurenine formamidase, vertebrates\/fungi-type KFase_ver\/fungi-typ

PIRSF : No PIRSF

Pdoc : No Pdoc

Pfam : PF07859 Abhydrolase_3

Prints : No Print

EC Number : 3.5.1.9

Sequences

Peptide in Fasta
Nucleotide in Fasta
Alignment with Multalin Text only
Seed alignment with MAFFT No colour
Alignment with MAFFT No colour
Dendrogram The dnd file

References (4)

Title : Biochemical identification and crystal structure of kynurenine formamidase from Drosophila melanogaster. - Han_2012_Biochem.J_446_253
Author(s) : Han Q , Robinson H , Li J
Ref : Biochemical Journal , 446 :253 , 2012
Abstract : Han_2012_Biochem.J_446_253
ESTHER : Han_2012_Biochem.J_446_253
PubMedSearch : Han_2012_Biochem.J_446_253
PubMedID: 22690733
Gene_locus related to this paper: drome-CG9542

Title : Identification of formyl kynurenine formamidase and kynurenine aminotransferase from Saccharomyces cerevisiae using crystallographic, bioinformatic and biochemical evidence - Wogulis_2008_Biochemistry_47_1608
Author(s) : Wogulis M , Chew ER , Donohoue PD , Wilson DK
Ref : Biochemistry , 47 :1608 , 2008
Abstract : Wogulis_2008_Biochemistry_47_1608
ESTHER : Wogulis_2008_Biochemistry_47_1608
PubMedSearch : Wogulis_2008_Biochemistry_47_1608
PubMedID: 18205391
Gene_locus related to this paper: yeast-YDR428C

Title : Crystal structure of an alpha\/beta serine hydrolase (YDR428C) from Saccharomyces cerevisiae at 1.85 A resolution -
Author(s) : Arndt JW , Schwarzenbacher R , Page R , Abdubek P , Ambing E , Biorac T , Canaves JM , Chiu HJ , Dai X , Deacon AM , DiDonato M , Elsliger MA , Godzik A , Grittini C , Grzechnik SK , Hale J , Hampton E , Han GW , Haugen J , Hornsby M , Klock HE , Koesema E , Kreusch A , Kuhn P , Jaroszewski L , Lesley SA , Levin I , McMullan D , McPhillips TM , Miller MD , Morse A , Moy K , Nigoghossian E , Ouyang J , Peti WS , Quijano K , Reyes R , Sims E , Spraggon G , Stevens RC , van den Bedem H , Velasquez J , Vincent J , von Delft F , Wang X , West B , White A , Wolf G , Xu Q , Zagnitko O , Hodgson KO , Wooley J , Wilson IA
Ref : Proteins , 58 :755 , 2005
PubMedID: 15624212
Gene_locus related to this paper: yeast-YDR428C

Title : Biochemical and genetic characterization of kynurenine formamidase from Drosophila melanogaster - Moore_1978_Biochem.Genet_16_619
Author(s) : Moore GP , Sullivan DT
Ref : Biochemical Genetics , 16 :619 , 1978
Abstract : Moore_1978_Biochem.Genet_16_619
ESTHER : Moore_1978_Biochem.Genet_16_619
PubMedSearch : Moore_1978_Biochem.Genet_16_619
PubMedID: 83140
Gene_locus related to this paper: drome-CG9542

Structures (4)

Genes Proteins in Kynurenine-formamidase family (364)

Fragments of genes in Kynurenine-formamidase family (5)

Structures in Kynurenine-formamidase family (4)

Substrates in Kynurenine-formamidase family (1)

Inhibitors in Kynurenine-formamidase family (2)