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Family Report for: LYsophospholipase_carboxylesterase

LYsophospholipase_carboxylesterase



Relationship
Block X
Comment
PLP_Cesterase. Abhydrolase_2; This family consists of both phospholipases and carboxylesterases with broad substrate specificity, but different of the family Monoglyceridelipase_lysophospholipase which is part of PF00561 AlphaBeta hydrolase. For bacterial enzymes, this family correspond to family VI of the classification of Arpigny and Jaeger (1999) The acyl protein thioesterases (APT1:LYPLA1, APT2: LYPLA2) are G protein depalmitoylases and accept also a number of S-palmitoylated protein and phospholipid substrates. Another closely related family of hydrolases: the ABHD17-depalmitoylase family contributes to the depalmitoylation of Ras-family GTPases and synaptic proteins. Burger et al. show that Acyl-protein thioesterase structures present a long tunnel for accommodation of long-chain fatty acids and release the product by use of a flexible loop tunnel lid. Homologous deacetylases use a hydrophobic residue to fix the lid and another residue to close the tunnel entrance. This causes loop rigidity changing the catalytic preference to deacetylation. SOBER1 is a protein deacetylase and not an acylprotein thioesterase. Family TE21 in ThYme database

Database
Sequences
Interpro
|
IPR003140 (Phospholipase/carboxylesterase/thioesterase PLP_Cesterase PLipase/COase/thioEstase)
PIRSF
|
Pdoc
|
PFam
|
PF02230 (Abhydrolase_2)
Prints
|
Prosite
|
EC at KEGG
|
EC at EXPASY
|


Peptide in
|Fasta
Nucleotide in
|Fasta
Alignment with Multalin
|Text only/graphic display
Seed alignment with MAFFT
|No colour/coloured with Mview
Alignment with MAFFT
|No colour/coloured with Mview
Dendrogram
|Graphical display, obtained with the dnd file produced by Clustalw

References
14 more
    Title: Lysophospholipases cooperate to mediate lipid homeostasis and lysophospholipid signaling
    Wepy JA, Galligan JJ, Kingsley PJ, Xu S, Goodman MC, Tallman KA, Rouzer CA, Marnett LJ
    Ref: J Lipid Res, 60:360, 2019 : PubMed

            

    Title: Protein depalmitoylases
    Won SJ, Cheung See Kit M, Martin BR
    Ref: Crit Rev Biochem Mol Biol, 53:83, 2018 : PubMed

            

    Title: A hydrophobic anchor mechanism defines a deacetylase family that suppresses host response against YopJ effectors
    Burger M, Willige BC, Chory J
    Ref: Nat Commun, 8:2201, 2017 : PubMed

            

Other Papers



Structures in LYsophospholipase_carboxylesterase family (27)

Genes Proteins in LYsophospholipase_carboxylesterase family (350)

Fragments of genes in LYsophospholipase_carboxylesterase family (14)

Substrates of some enzymes in the LYsophospholipase_carboxylesterase family (20)

Inhibitors of some enzymes in the LYsophospholipase_carboxylesterase family (24)



Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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