Lipase_3
Comment
Triglyceride lipases are lipases that hydrolyse ester linkages of triglycerides. These lipases are widely distributed in animals, plants and prokaryotes. This family was also called class 3 lipases as they are only distantly related to other lipase families. In some fungi DDHD domain Pfam PF02862 180 residues long containing four conserved residues that may form a metal binding site is associated with the Lipase_3. Bacterial enzymes (LipG Lee et al. 2006) belong to family XI of the classification of Arpigny and Jaeger 1999.
The (phospho)lipase of F.solani has the highest microbial activity on galactolipids Jallouli et al. Feruloyl esterases are enzymes produced by micro-organisms to deconstruct plant cell walls by hydrolyzing phenolic groups involved in the cross-linking of arabinoxylan to other polymeric structures. The non-modular type-A feruloyl esterase from Aspergillus niger AnFaeA is similar to fungal lipases and different from other feruloyl esterases. Feruloyl esterases are distributed in different sub-classes type-A B C,D and E and fall respectively in the following families. Type-A in Lipase_3, Type-B in Esterase_phb (PHB depolymerase), Type-C in Tannase, Type-D in FaeC, Type-E in A85-Feruloyl-Esterase, Type-F in BD-FAE. (cd00741: Lipase) Database
Interpro : IPR000734 Lipase , IPR002921 Fungal_lipase-like domain , IPR005592 Mono-\/di-acylglycerol lipase, N-terminal Mono\/diacylglycerol_lipase_N
PIRSF : No PIRSF
Pdoc : PDOC00110
Pfam : PF03893 Lipase3_N , PF01764 Lipase_3
Prints : PR00821
EC Number : 3.1.1.3
References (17)
| Title : Diacylglycerol Lipase-beta Knockout Mice Display a Sex-Dependent Attenuation of Traumatic Brain Injury-Induced Mortality with No Impact on Memory or Other Functional Consequences - O'Brien_2021_Cannabis.Cannabinoid.Res__ |
| Author(s) : O'Brien LD , Smith TL , Donvito G , Cravatt BF , Newton J , Spiegel S , Reeves TM , Phillips LL , Lichtman AH |
| Ref : Cannabis Cannabinoid Res , : , 2021 |
| Abstract : O'Brien_2021_Cannabis.Cannabinoid.Res__ |
| ESTHER : O'Brien_2021_Cannabis.Cannabinoid.Res__ |
| PubMedSearch : O'Brien_2021_Cannabis.Cannabinoid.Res__ |
| PubMedID: 34142866 |
| Gene_locus related to this paper: human-DAGLB , mouse-DGLB |
| Title : A simple and versatile microfluidic device for efficient biomacromolecule crystallization and structural analysis by serial crystallography - de Wijn_2019_IUCrJ_6_454 |
| Author(s) : de Wijn R , Hennig O , Roche J , Engilberge S , Rollet K , Fernandez-Millan P , Brillet K , Betat H , Morl M , Roussel A , Girard E , Mueller-Dieckmann C , Fox GC , Olieric V , Gavira JA , Lorber B , Sauter C |
| Ref : IUCrJ , 6 :454 , 2019 |
| Abstract : de Wijn_2019_IUCrJ_6_454 |
| ESTHER : de Wijn_2019_IUCrJ_6_454 |
| PubMedSearch : de Wijn_2019_IUCrJ_6_454 |
| PubMedID: 31098026 |
| Gene_locus related to this paper: humla-1lipa |
| Title : Rapid and profound rewiring of brain lipid signaling networks by acute diacylglycerol lipase inhibition - Ogasawara_2016_Proc.Natl.Acad.Sci.U.S.A_113_26 |
| Author(s) : Ogasawara D , Deng H , Viader A , Baggelaar MP , Breman A , den Dulk H , van den Nieuwendijk AM , Soethoudt M , van der Wel T , Zhou J , Overkleeft HS , Sanchez-Alavez M , Mori S , Nguyen W , Conti B , Liu X , Chen Y , Liu QS , Cravatt BF , van der Stelt M |
| Ref : Proc Natl Acad Sci U S A , 113 :26 , 2016 |
| Abstract : Ogasawara_2016_Proc.Natl.Acad.Sci.U.S.A_113_26 |
| ESTHER : Ogasawara_2016_Proc.Natl.Acad.Sci.U.S.A_113_26 |
| PubMedSearch : Ogasawara_2016_Proc.Natl.Acad.Sci.U.S.A_113_26 |
| PubMedID: 26668358 |
| Gene_locus related to this paper: human-DAGLA , human-DAGLB |
| Title : The galactolipase activity of Fusarium solani (phospho)lipase - Jallouli_2015_Biochim.Biophys.Acta_1851_282 |
| Author(s) : Jallouli R , Othman H , Amara S , Parsiegla G , Carriere F , Srairi-Abid N , Gargouri Y , Bezzine S |
| Ref : Biochimica & Biophysica Acta , 1851 :282 , 2015 |
| Abstract : Jallouli_2015_Biochim.Biophys.Acta_1851_282 |
| ESTHER : Jallouli_2015_Biochim.Biophys.Acta_1851_282 |
| PubMedSearch : Jallouli_2015_Biochim.Biophys.Acta_1851_282 |
| PubMedID: 25529980 |
| Gene_locus related to this paper: nech7-c7yuz1 |
| Title : Crystal structure of a secreted lipase from Gibberella zeae reveals a novel double-lock mechanism - Lou_2010_Protein.Cell_1_760 |
| Author(s) : Lou Z , Li M , Sun Y , Liu Y , Liu Z , Wu W , Rao Z |
| Ref : Protein Cell , 1 :760 , 2010 |
| Abstract : Lou_2010_Protein.Cell_1_760 |
| ESTHER : Lou_2010_Protein.Cell_1_760 |
| PubMedSearch : Lou_2010_Protein.Cell_1_760 |
| PubMedID: 21203917 |
| Gene_locus related to this paper: gibze-q6wer3 |
| Title : Structural redesign of lipase B from Candida antarctica by circular permutation and incremental truncation - Qian_2009_J.Mol.Biol_393_191 |
| Author(s) : Qian Z , Horton JR , Cheng X , Lutz S |
| Ref : Journal of Molecular Biology , 393 :191 , 2009 |
| Abstract : Qian_2009_J.Mol.Biol_393_191 |
| ESTHER : Qian_2009_J.Mol.Biol_393_191 |
| PubMedSearch : Qian_2009_J.Mol.Biol_393_191 |
| PubMedID: 19683009 |
| Gene_locus related to this paper: canar-LipB |
| Title : Structural basis for the cold adaptation of psychrophilic M37 lipase from Photobacterium lipolyticum - Jung_2008_Proteins_71_476 |
| Author(s) : Jung SK , Jeong DG , Lee MS , Lee JK , Kim HK , Ryu SE , Park BC , Kim JH , Kim SJ |
| Ref : Proteins , 71 :476 , 2008 |
| Abstract : Jung_2008_Proteins_71_476 |
| ESTHER : Jung_2008_Proteins_71_476 |
| PubMedSearch : Jung_2008_Proteins_71_476 |
| PubMedID: 18186467 |
| Gene_locus related to this paper: 9gamm-q5drn8 |
| Title : Feruloyl esterase: a key enzyme in biomass degradation - Wong_2006_Appl.Biochem.Biotechnol_133_87 |
| Author(s) : Wong DWS |
| Ref : Appl Biochem Biotechnol , 133 :87 , 2006 |
| Abstract : Wong_2006_Appl.Biochem.Biotechnol_133_87 |
| ESTHER : Wong_2006_Appl.Biochem.Biotechnol_133_87 |
| PubMedSearch : Wong_2006_Appl.Biochem.Biotechnol_133_87 |
| PubMedID: 16702605 |
| Title : Isolation and characterization of a novel lipase from a metagenomic library of tidal flat sediments: evidence for a new family of bacterial lipases - Lee_2006_Appl.Environ.Microbiol_72_7406 |
| Author(s) : Lee MH , Lee CH , Oh TK , Song JK , Yoon JH |
| Ref : Applied Environmental Microbiology , 72 :7406 , 2006 |
| Abstract : Lee_2006_Appl.Environ.Microbiol_72_7406 |
| ESTHER : Lee_2006_Appl.Environ.Microbiol_72_7406 |
| PubMedSearch : Lee_2006_Appl.Environ.Microbiol_72_7406 |
| PubMedID: 16950897 |
| Gene_locus related to this paper: 9bact-q1paf1 |
| Title : The crystal structure of feruloyl esterase A from Aspergillus niger suggests evolutive functional convergence in feruloyl esterase family - Hermoso_2004_J.Mol.Biol_338_495 |
| Author(s) : Hermoso JA , Sanz-Aparicio J , Molina R , Juge N , Gonzalez R , Faulds CB |
| Ref : Journal of Molecular Biology , 338 :495 , 2004 |
| Abstract : Hermoso_2004_J.Mol.Biol_338_495 |
| ESTHER : Hermoso_2004_J.Mol.Biol_338_495 |
| PubMedSearch : Hermoso_2004_J.Mol.Biol_338_495 |
| PubMedID: 15081808 |
| Gene_locus related to this paper: aspni-FAEA |
| Title : Structure of a feruloyl esterase from Aspergillus niger - McAuley_2004_Acta.Crystallogr.D.Biol.Crystallogr_60_878 |
| Author(s) : McAuley KE , Svendsen A , Patkar SA , Wilson KS |
| Ref : Acta Crystallographica D Biol Crystallogr , 60 :878 , 2004 |
| Abstract : McAuley_2004_Acta.Crystallogr.D.Biol.Crystallogr_60_878 |
| ESTHER : McAuley_2004_Acta.Crystallogr.D.Biol.Crystallogr_60_878 |
| PubMedSearch : McAuley_2004_Acta.Crystallogr.D.Biol.Crystallogr_60_878 |
| PubMedID: 15103133 |
| Gene_locus related to this paper: aspni-FAEA |
| Title : The faeA genes from Aspergillus niger and Aspergillus tubingensis encode ferulic acid esterases involved in degradation of complex cell wall polysaccharides - de Vries_1997_Appl.Environ.Microbiol_63_4638 |
| Author(s) : de Vries RP , Michelsen B , Poulsen CH , Kroon PA , van den Heuvel RH , Faulds CB , Williamson G , van den Hombergh JP , Visser J |
| Ref : Applied Environmental Microbiology , 63 :4638 , 1997 |
| Abstract : de Vries_1997_Appl.Environ.Microbiol_63_4638 |
| ESTHER : de Vries_1997_Appl.Environ.Microbiol_63_4638 |
| PubMedSearch : de Vries_1997_Appl.Environ.Microbiol_63_4638 |
| PubMedID: 9406381 |
| Gene_locus related to this paper: aspni-FAEA , asptu-FAEA |
| Title : The sequence, crystal structure determination and refinement of two crystal forms of lipase B from Candida antarctica - Uppenberg_1994_Structure_2_293 |
| Author(s) : Uppenberg J , Hansen MT , Patkar S , Jones TA |
| Ref : Structure , 2 :293 , 1994 |
| Abstract : Uppenberg_1994_Structure_2_293 |
| ESTHER : Uppenberg_1994_Structure_2_293 |
| PubMedSearch : Uppenberg_1994_Structure_2_293 |
| PubMedID: 8087556 |
| Gene_locus related to this paper: canar-LipB |
| Title : Conformational lability of lipases observed in the absence of an oil-water interface: crystallographic studies of enzymes from the fungi Humicola lanuginosa and Rhizopus delemar - Derewenda_1994_J.Lipid.Res_35_524 |
| Author(s) : Derewenda U , Swenson L , Wei Y , Green R , Kobos PM , Joerger R , Haas MJ , Derewenda ZS |
| Ref : J Lipid Res , 35 :524 , 1994 |
| Abstract : Derewenda_1994_J.Lipid.Res_35_524 |
| ESTHER : Derewenda_1994_J.Lipid.Res_35_524 |
| PubMedSearch : Derewenda_1994_J.Lipid.Res_35_524 |
| PubMedID: 8014587 |
| Gene_locus related to this paper: humla-1lipa , rhidl-lipas |
| Title : An unusual buried polar cluster in a family of fungal lipases - Derewenda_1994_Nat.Struct.Biol_1_36 |
| Author(s) : Derewenda U , Swenson L , Green R , Wei Y , Dodson GG , Yamaguchi S , Haas MJ , Derewenda ZS |
| Ref : Nat Struct Biol , 1 :36 , 1994 |
| Abstract : Derewenda_1994_Nat.Struct.Biol_1_36 |
| ESTHER : Derewenda_1994_Nat.Struct.Biol_1_36 |
| PubMedSearch : Derewenda_1994_Nat.Struct.Biol_1_36 |
| PubMedID: 7656005 |
| Gene_locus related to this paper: humla-1lipa , penca-mdgli , rhidl-lipas |
| Title : Current progress in crystallographic studies of new lipases from filamentous fungi - Derewenda_1994_Protein.Eng_7_551 |
| Author(s) : Derewenda U , Swenson L , Green R , Wei Y , Yamaguchi S , Joerger R , Haas MJ , Derewenda ZS |
| Ref : Protein Engineering , 7 :551 , 1994 |
| Abstract : Derewenda_1994_Protein.Eng_7_551 |
| ESTHER : Derewenda_1994_Protein.Eng_7_551 |
| PubMedSearch : Derewenda_1994_Protein.Eng_7_551 |
| PubMedID: 8029211 |
| Gene_locus related to this paper: humla-1lipa , penca-mdgli , rhidl-lipas |
| Title : A serine protease triad forms the catalytic centre of a triacylglycerol lipase - Brady_1990_Nature_343_767 |
| Author(s) : Brady L , Brzozowski AM , Derewenda ZS , Dodson E , Dodson G , Tolley S , Turkenburg JP , Christiansen L , Huge-Jensen B , Norskov L , Thim L , Menge U |
| Ref : Nature , 343 :767 , 1990 |
| Abstract : Brady_1990_Nature_343_767 |
| ESTHER : Brady_1990_Nature_343_767 |
| PubMedSearch : Brady_1990_Nature_343_767 |
| PubMedID: 2304552 |
| Gene_locus related to this paper: rhimi-lipas |
Structures (61)
Genes Proteins in Lipase_3 family (405)
Fragments of genes in Lipase_3 family (39)
Structures in Lipase_3 family (61)Substrates in Lipase_3 family (39)
Inhibitors in Lipase_3 family (29)