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Family Report for: Lipase_3


Family Lipase_3
Block L
Triglyceride lipases are lipases that hydrolyse ester linkages of triglycerides. These lipases are widely distributed in animals, plants and prokaryotes. This family was also called class 3 lipases as they are only distantly related to other lipase families. In some fungi DDHD domain Pfam PF02862 180 residues long containing four conserved residues that may form a metal binding site is associated with the Lipase_3. Bacterial enzymes (LipG Lee et al. 2006) belong to family XI of the classification of Arpigny and Jaeger 1999. The (phospho)lipase of F.solani has the highest microbial activity on galactolipids Jallouli et al. Feruloyl esterases are enzymes produced by micro-organisms to deconstruct plant cell walls by hydrolyzing phenolic groups involved in the cross-linking of arabinoxylan to other polymeric structures. The non-modular type-A feruloyl esterase from Aspergillus niger AnFaeA is similar to fungal lipases and different from other feruloyl esterases. Feruloyl esterases are distributed in different sub-classes type-A B C,D and E and fall respectively in the following families. Type-A in Lipase_3, Type-B in Esterase_phb (PHB depolymerase), Type-C in Tannase, Type-D in FaeC, Type-E in A85-Feruloyl-Esterase, Type-F in BD-FAE
2 Disease(s)

IPR000734 (Lipase), IPR002921 (Fungal_lipase-like domain), IPR005592 (Mono-/di-acylglycerol lipase, N-terminal Mono/diacylglycerol_lipase_N)
PF03893 (Lipase3_N), PF01764 (Lipase_3)

Peptide in
Nucleotide in
Alignment with Multalin
|Text only/graphic display
Seed alignment with MAFFT
|No colour/coloured with Mview
Alignment with MAFFT
|No colour/coloured with Mview
|Graphical display, obtained with the dnd file produced by Clustalw

14 more
    Title: A simple and versatile microfluidic device for efficient biomacromolecule crystallization and structural analysis by serial crystallography
    de Wijn R, Hennig O, Roche J, Engilberge S, Rollet K, Fernandez-Millan P, Brillet K, Betat H, Morl M and Sauter C <7 more author(s)>
    Ref: IUCrJ, 6:454, 2019 : PubMed


    Title: The galactolipase activity of Fusarium solani (phospho)lipase
    Jallouli R, Othman H, Amara S, Parsiegla G, Carriere F, Srairi-Abid N, Gargouri Y, Bezzine S
    Ref: Biochimica & Biophysica Acta, 1851:282, 2015 : PubMed


    Title: Current progress in crystallographic studies of new lipases from filamentous fungi
    Derewenda U, Swenson L, Green R, Wei Y, Yamaguchi S, Joerger R, Haas MJ, Derewenda ZS
    Ref: Protein Engineering, 7:551, 1994 : PubMed


Other Papers

Structure scheme for Lipase_3

Structures in Lipase_3 family (61)

Genes Proteins in Lipase_3 family (439)

Fragments of genes in Lipase_3 family (41)

Substrates of some enzymes in the Lipase_3 family (34)

Inhibitors of some enzymes in the Lipase_3 family (28)

Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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