Interpro : IPR000734 Lipase , IPR002330 Lipoprotein lipase , IPR016272 Lipase, LIPH-type , IPR013818 Lipase
PIRSF : No PIRSF
Pdoc : PDOC00110
Pfam : PF00151 Lipase
Prints : PR00821 , PR00822
EC Number : 3.1.1.34
Title : The GPIHBP1-LPL complex and its role in plasma triglyceride metabolism: Insights into chylomicronemia - Jiang_2023_Biomed.Pharmacother_169_115874 |
Author(s) : Jiang S , Ren Z , Yang Y , Liu Q , Zhou S , Xiao Y |
Ref : Biomed Pharmacother , 169 :115874 , 2023 |
Abstract : Jiang_2023_Biomed.Pharmacother_169_115874 |
ESTHER : Jiang_2023_Biomed.Pharmacother_169_115874 |
PubMedSearch : Jiang_2023_Biomed.Pharmacother_169_115874 |
PubMedID: 37951027 |
Title : The lipoprotein lipase that is shuttled into capillaries by GPIHBP1 enters the glycocalyx where it mediates lipoprotein processing - Song_2023_Proc.Natl.Acad.Sci.U.S.A_120_e2313825120 |
Author(s) : Song W , Beigneux AP , Weston TA , Chen K , Yang Y , Nguyen LP , Guagliardo P , Jung H , Tran AP , Tu Y , Tran C , Birrane G , Miyashita K , Nakajima K , Murakami M , Tontonoz P , Jiang H , Ploug M , Fong LG , Young SG |
Ref : Proc Natl Acad Sci U S A , 120 :e2313825120 , 2023 |
Abstract : Song_2023_Proc.Natl.Acad.Sci.U.S.A_120_e2313825120 |
ESTHER : Song_2023_Proc.Natl.Acad.Sci.U.S.A_120_e2313825120 |
PubMedSearch : Song_2023_Proc.Natl.Acad.Sci.U.S.A_120_e2313825120 |
PubMedID: 37871217 |
Title : Angiopoietin-like protein 8: a multifaceted protein instrumental in regulating triglyceride metabolism - Wen_2023_Curr.Opin.Lipidol__ |
Author(s) : Wen Y , Chen YQ , Konrad RJ |
Ref : Curr Opin Lipidol , : , 2023 |
Abstract : Wen_2023_Curr.Opin.Lipidol__ |
ESTHER : Wen_2023_Curr.Opin.Lipidol__ |
PubMedSearch : Wen_2023_Curr.Opin.Lipidol__ |
PubMedID: 37962908 |
Title : Inverse effects of APOC2 and ANGPTL4 on the conformational dynamics of lid-anchoring structures in lipoprotein lipase - Kumari_2023_Proc.Natl.Acad.Sci.U.S.A_120_e2221888120 |
Author(s) : Kumari A , Gronnemose AL , Kristensen KK , Winther AL , Young SG , Jorgensen TJD , Ploug M |
Ref : Proc Natl Acad Sci U S A , 120 :e2221888120 , 2023 |
Abstract : Kumari_2023_Proc.Natl.Acad.Sci.U.S.A_120_e2221888120 |
ESTHER : Kumari_2023_Proc.Natl.Acad.Sci.U.S.A_120_e2221888120 |
PubMedSearch : Kumari_2023_Proc.Natl.Acad.Sci.U.S.A_120_e2221888120 |
PubMedID: 37094117 |
Gene_locus related to this paper: human-LPL |
Title : Transcriptome-wide association study reveals cholesterol metabolism gene Lpl is a key regulator of cognitive dysfunction - Hu_2022_Front.Mol.Neurosci_15_1044022 |
Author(s) : Hu W , Liu J , Hu Y , Xu Q , Deng T , Wei M , Lu L , Mi J , Bergquist J , Xu F , Tian G |
Ref : Front Mol Neurosci , 15 :1044022 , 2022 |
Abstract : Hu_2022_Front.Mol.Neurosci_15_1044022 |
ESTHER : Hu_2022_Front.Mol.Neurosci_15_1044022 |
PubMedSearch : Hu_2022_Front.Mol.Neurosci_15_1044022 |
PubMedID: 36590920 |
Title : Lipoprotein Lipase and Its Regulators: An Unfolding Story - Wu_2021_Trends.Endocrinol.Metab_32_48 |
Author(s) : Wu SA , Kersten S , Qi L |
Ref : Trends Endocrinol Metab , 32 :48 , 2021 |
Abstract : Wu_2021_Trends.Endocrinol.Metab_32_48 |
ESTHER : Wu_2021_Trends.Endocrinol.Metab_32_48 |
PubMedSearch : Wu_2021_Trends.Endocrinol.Metab_32_48 |
PubMedID: 33277156 |
Gene_locus related to this paper: human-LPL |
Title : The intrinsic instability of the hydrolase domain of lipoprotein lipase facilitates its inactivation by ANGPTL4-catalyzed unfolding - Leth-Espensen_2021_Proc.Natl.Acad.Sci.U.S.A_118_e2026650118 |
Author(s) : Leth-Espensen KZ , Kristensen KK , Kumari A , Winther AL , Young SG , Jorgensen TJD , Ploug M |
Ref : Proc Natl Acad Sci U S A , 118 : , 2021 |
Abstract : Leth-Espensen_2021_Proc.Natl.Acad.Sci.U.S.A_118_e2026650118 |
ESTHER : Leth-Espensen_2021_Proc.Natl.Acad.Sci.U.S.A_118_e2026650118 |
PubMedSearch : Leth-Espensen_2021_Proc.Natl.Acad.Sci.U.S.A_118_e2026650118 |
PubMedID: 33723082 |
Gene_locus related to this paper: human-LPL |
Title : The structure of helical lipoprotein lipase reveals an unexpected twist in lipase storage - Gunn_2020_Proc.Natl.Acad.Sci.U.S.A_117_10254 |
Author(s) : Gunn KH , Roberts BS , Wang F , Strauss JD , Borgnia MJ , Egelman EH , Neher SB |
Ref : Proc Natl Acad Sci U S A , 117 :10254 , 2020 |
Abstract : Gunn_2020_Proc.Natl.Acad.Sci.U.S.A_117_10254 |
ESTHER : Gunn_2020_Proc.Natl.Acad.Sci.U.S.A_117_10254 |
PubMedSearch : Gunn_2020_Proc.Natl.Acad.Sci.U.S.A_117_10254 |
PubMedID: 32332168 |
Gene_locus related to this paper: bovin-lipli , human-LPL |
Title : Structure of lipoprotein lipase in complex with GPIHBP1 - Arora_2019_Proc.Natl.Acad.Sci.U.S.A_116_10360 |
Author(s) : Arora R , Nimonkar AV , Baird D , Wang C , Chiu CH , Horton PA , Hanrahan S , Cubbon R , Weldon S , Tschantz WR , Mueller S , Brunner R , Lehr P , Meier P , Ottl J , Voznesensky A , Pandey P , Smith TM , Stojanovic A , Flyer A , Benson TE , Romanowski MJ , Trauger JW |
Ref : Proc Natl Acad Sci U S A , 116 :10360 , 2019 |
Abstract : Arora_2019_Proc.Natl.Acad.Sci.U.S.A_116_10360 |
ESTHER : Arora_2019_Proc.Natl.Acad.Sci.U.S.A_116_10360 |
PubMedSearch : Arora_2019_Proc.Natl.Acad.Sci.U.S.A_116_10360 |
PubMedID: 31072929 |
Gene_locus related to this paper: human-LPL |
Title : Structure of the lipoprotein lipase-GPIHBP1 complex that mediates plasma triglyceride hydrolysis - Birrane_2019_Proc.Natl.Acad.Sci.U.S.A_116_1723 |
Author(s) : Birrane G , Beigneux AP , Dwyer B , Strack-Logue B , Kristensen KK , Francone OL , Fong LG , Mertens HDT , Pan CQ , Ploug M , Young SG , Meiyappan M |
Ref : Proc Natl Acad Sci U S A , 116 :1723 , 2019 |
Abstract : Birrane_2019_Proc.Natl.Acad.Sci.U.S.A_116_1723 |
ESTHER : Birrane_2019_Proc.Natl.Acad.Sci.U.S.A_116_1723 |
PubMedSearch : Birrane_2019_Proc.Natl.Acad.Sci.U.S.A_116_1723 |
PubMedID: 30559189 |
Gene_locus related to this paper: human-LPL |
Title : GPIHBP1 and Lipoprotein Lipase, Partners in Plasma Triglyceride Metabolism - Young_2019_Cell.Metab_30_51 |
Author(s) : Young SG , Fong LG , Beigneux AP , Allan CM , He C , Jiang H , Nakajima K , Meiyappan M , Birrane G , Ploug M |
Ref : Cell Metab , 30 :51 , 2019 |
Abstract : Young_2019_Cell.Metab_30_51 |
ESTHER : Young_2019_Cell.Metab_30_51 |
PubMedSearch : Young_2019_Cell.Metab_30_51 |
PubMedID: 31269429 |
Gene_locus related to this paper: human-LPL |
Title : GPIHBP1 expression in gliomas promotes utilization of lipoprotein-derived nutrients - Hu_2019_Elife_8_e47178 |
Author(s) : Hu X , Matsumoto K , Jung RS , Weston TA , Heizer PJ , He C , Sandoval NP , Allan CM , Tu Y , Vinters HV , Liau LM , Ellison RM , Morales JE , Baufeld LJ , Bayley NA , He L , Betsholtz C , Beigneux AP , Nathanson DA , Gerhardt H , Young SG , Fong LG , Jiang H |
Ref : Elife , 8 : , 2019 |
Abstract : Hu_2019_Elife_8_e47178 |
ESTHER : Hu_2019_Elife_8_e47178 |
PubMedSearch : Hu_2019_Elife_8_e47178 |
PubMedID: 31169500 |
Title : A disordered acidic domain in GPIHBP1 harboring a sulfated tyrosine regulates lipoprotein lipase - Kristensen_2018_Proc.Natl.Acad.Sci.U.S.A_115_E6020 |
Author(s) : Kristensen KK , Midtgaard SR , Mysling S , Kovrov O , Hansen LB , Skar-Gislinge N , Beigneux AP , Kragelund BB , Olivecrona G , Young SG , Jorgensen TJD , Fong LG , Ploug M |
Ref : Proc Natl Acad Sci U S A , 115 :E6020 , 2018 |
Abstract : Kristensen_2018_Proc.Natl.Acad.Sci.U.S.A_115_E6020 |
ESTHER : Kristensen_2018_Proc.Natl.Acad.Sci.U.S.A_115_E6020 |
PubMedSearch : Kristensen_2018_Proc.Natl.Acad.Sci.U.S.A_115_E6020 |
PubMedID: 29899144 |
Title : Mobility of HSPG-bound LPL explains how LPL is able to reach GPIHBP1 on capillaries - Allan_2017_J.Lipid.Res_58_216 |
Author(s) : Allan CM , Larsson M , Jung RS , Ploug M , Bensadoun A , Beigneux AP , Fong LG , Young SG |
Ref : J Lipid Res , 58 :216 , 2017 |
Abstract : Allan_2017_J.Lipid.Res_58_216 |
ESTHER : Allan_2017_J.Lipid.Res_58_216 |
PubMedSearch : Allan_2017_J.Lipid.Res_58_216 |
PubMedID: 27811232 |
Title : The acidic domain of the endothelial membrane protein GPIHBP1 stabilizes lipoprotein lipase activity by preventing unfolding of its catalytic domain - Mysling_2016_Elife_5_e12095 |
Author(s) : Mysling S , Kristensen KK , Larsson M , Beigneux AP , Gardsvoll H , Loren FG , Bensadouen A , Jorgensen TJ , Young SG , Ploug M |
Ref : Elife , 5 : , 2016 |
Abstract : Mysling_2016_Elife_5_e12095 |
ESTHER : Mysling_2016_Elife_5_e12095 |
PubMedSearch : Mysling_2016_Elife_5_e12095 |
PubMedID: 26725083 |
Title : GPIHBP1 missense mutations often cause multimerization of GPIHBP1 and thereby prevent lipoprotein lipase binding - Beigneux_2015_Circ.Res_116_624 |
Author(s) : Beigneux AP , Fong LG , Bensadoun A , Davies BS , Oberer M , Gardsvoll H , Ploug M , Young SG |
Ref : Circulation Research , 116 :624 , 2015 |
Abstract : Beigneux_2015_Circ.Res_116_624 |
ESTHER : Beigneux_2015_Circ.Res_116_624 |
PubMedSearch : Beigneux_2015_Circ.Res_116_624 |
PubMedID: 25387803 |
Title : Hippocampal lipoprotein lipase regulates energy balance in rodents - Picard_2014_Mol.Metab_3_167 |
Author(s) : Picard A , Rouch C , Kassis N , Moulle VS , Croizier S , Denis RG , Castel J , Coant N , Davis K , Clegg DJ , Benoit SC , Prevot V , Bouret S , Luquet S , Le Stunff H , Cruciani-Guglielmacci C , Magnan C |
Ref : Mol Metab , 3 :167 , 2014 |
Abstract : Picard_2014_Mol.Metab_3_167 |
ESTHER : Picard_2014_Mol.Metab_3_167 |
PubMedSearch : Picard_2014_Mol.Metab_3_167 |
PubMedID: 24634821 |
Title : The GPIHBP1-LPL complex is responsible for the margination of triglyceride-rich lipoproteins in capillaries - Goulbourne_2014_Cell.Metab_19_849 |
Author(s) : Goulbourne CN , Gin P , Tatar A , Nobumori C , Hoenger A , Jiang H , Grovenor CR , Adeyo O , Esko JD , Goldberg IJ , Reue K , Tontonoz P , Bensadoun A , Beigneux AP , Young SG , Fong LG |
Ref : Cell Metab , 19 :849 , 2014 |
Abstract : Goulbourne_2014_Cell.Metab_19_849 |
ESTHER : Goulbourne_2014_Cell.Metab_19_849 |
PubMedSearch : Goulbourne_2014_Cell.Metab_19_849 |
PubMedID: 24726386 |
Title : Angiopoietin-like protein 4 inhibition of lipoprotein lipase: evidence for reversible complex formation - Lafferty_2013_J.Biol.Chem_288_28524 |
Author(s) : Lafferty MJ , Bradford KC , Erie DA , Neher SB |
Ref : Journal of Biological Chemistry , 288 :28524 , 2013 |
Abstract : Lafferty_2013_J.Biol.Chem_288_28524 |
ESTHER : Lafferty_2013_J.Biol.Chem_288_28524 |
PubMedSearch : Lafferty_2013_J.Biol.Chem_288_28524 |
PubMedID: 23960078 |
Gene_locus related to this paper: human-LPL |
Title : Assessing mechanisms of GPIHBP1 and lipoprotein lipase movement across endothelial cells - Davies_2012_J.Lipid.Res_53_2690 |
Author(s) : Davies BS , Goulbourne CN , Barnes RH, 2nd , Turlo KA , Gin P , Vaughan S , Vaux DJ , Bensadoun A , Beigneux AP , Fong LG , Young SG |
Ref : J Lipid Res , 53 :2690 , 2012 |
Abstract : Davies_2012_J.Lipid.Res_53_2690 |
ESTHER : Davies_2012_J.Lipid.Res_53_2690 |
PubMedSearch : Davies_2012_J.Lipid.Res_53_2690 |
PubMedID: 23008484 |
Gene_locus related to this paper: human-LPL |
Title : Mutations in lipoprotein lipase that block binding to the endothelial cell transporter GPIHBP1 - Voss_2011_Proc.Natl.Acad.Sci.U.S.A_108_7980 |
Author(s) : Voss CV , Davies BS , Tat S , Gin P , Fong LG , Pelletier C , Mottler CD , Bensadoun A , Beigneux AP , Young SG |
Ref : Proc Natl Acad Sci U S A , 108 :7980 , 2011 |
Abstract : Voss_2011_Proc.Natl.Acad.Sci.U.S.A_108_7980 |
ESTHER : Voss_2011_Proc.Natl.Acad.Sci.U.S.A_108_7980 |
PubMedSearch : Voss_2011_Proc.Natl.Acad.Sci.U.S.A_108_7980 |
PubMedID: 21518912 |
Gene_locus related to this paper: human-LPL |
Title : GPIHBP1 is responsible for the entry of lipoprotein lipase into capillaries - Davies_2010_Cell.Metab_12_42 |
Author(s) : Davies BS , Beigneux AP , Barnes RH, 2nd , Tu Y , Gin P , Weinstein MM , Nobumori C , Nyren R , Goldberg I , Olivecrona G , Bensadoun A , Young SG , Fong LG |
Ref : Cell Metab , 12 :42 , 2010 |
Abstract : Davies_2010_Cell.Metab_12_42 |
ESTHER : Davies_2010_Cell.Metab_12_42 |
PubMedSearch : Davies_2010_Cell.Metab_12_42 |
PubMedID: 20620994 |
Title : Association of lipoprotein lipase D9N polymorphism with myocardial infarction in type 2 diabetes: the genetics, outcomes, and lipids in type 2 diabetes (GOLD) study - Izar_2009_Atherosclerosis_204_165 |
Author(s) : Izar MC , Helfenstein T , Ihara SS , Relvas WG , Santos AO , Fischer SC , Pinto LE , Lopes IE , Pomaro DR , Fonseca MI , Bodanese LC , Moriguchi EH , Saraiva JF , Introcaso L , Souza AD , Scartezini M , Torres KP , Zagury L , Jardim PC , Costa EA , Tacito LH , Forti A , Magalhaes ME , Chacra AR , Bertolami MC , Loures-Vale AA , Barros MA , Xavier HT , Lyra R , Argamanijan D , Guimaraes A , Novazzi JP , Kasinski N , Afiune A , Martinez TL , Santos RD , Nicolau JC , Cesar LA , Povoa RM , Carvalho AC , Han SW , Fonseca FA |
Ref : Atherosclerosis , 204 :165 , 2009 |
Abstract : Izar_2009_Atherosclerosis_204_165 |
ESTHER : Izar_2009_Atherosclerosis_204_165 |
PubMedSearch : Izar_2009_Atherosclerosis_204_165 |
PubMedID: 18823627 |
Gene_locus related to this paper: human-LPL |
Title : Cloning of a unique lipase from endothelial cells extends the lipase gene family. - |
Author(s) : Hirata K , Dichek HL , Cioffi JA , Choi SY , Leeper NJ , Quintana L , Kronmal GS , Cooper AD , Quertermous T |
Ref : Journal of Biological Chemistry , 274 :14170 , 1999 |
PubMedID: 10318835 |
Gene_locus related to this paper: human-LIPG , mouse-Lipg |
Title : A novel endothelial-derived lipase that modulates HDL metabolism - Jaye_1999_Nat.Genet_21_424 |
Author(s) : Jaye M , Lynch KJ , Krawiec J , Marchadier D , Maugeais C , Doan K , South V , Amin D , Perrone M , Rader DJ |
Ref : Nat Genet , 21 :424 , 1999 |
Abstract : Jaye_1999_Nat.Genet_21_424 |
ESTHER : Jaye_1999_Nat.Genet_21_424 |
PubMedSearch : Jaye_1999_Nat.Genet_21_424 |
PubMedID: 10192396 |
Gene_locus related to this paper: human-LIPG |
Title : Lipoprotein lipase. Molecular model based on the pancreatic lipase x-ray structure: consequences for heparin binding and catalysis - van Tilbeurgh_1994_J.Biol.Chem_269_4626 |
Author(s) : van Tilbeurgh H , Roussel A , Lalouel JM , Cambillau C |
Ref : Journal of Biological Chemistry , 269 :4626 , 1994 |
Abstract : van Tilbeurgh_1994_J.Biol.Chem_269_4626 |
ESTHER : van Tilbeurgh_1994_J.Biol.Chem_269_4626 |
PubMedSearch : van Tilbeurgh_1994_J.Biol.Chem_269_4626 |
PubMedID: 8308035 |
Title : Lipoprotein lipase enhances the interaction of low density lipoproteins with artery-derived extracellular matrix proteoglycans - Edwards_1993_J.Lipid.Res_34_1155 |
Author(s) : Edwards IJ , Goldberg IJ , Parks JS , Xu H , Wagner WD |
Ref : J Lipid Res , 34 :1155 , 1993 |
Abstract : Edwards_1993_J.Lipid.Res_34_1155 |
ESTHER : Edwards_1993_J.Lipid.Res_34_1155 |
PubMedSearch : Edwards_1993_J.Lipid.Res_34_1155 |
PubMedID: 8371063 |
Title : Lipoprotein lipase enhances binding of lipoproteins to heparan sulfate on cell surfaces and extracellular matrix - Eisenberg_1992_J.Clin.Invest_90_2013 |
Author(s) : Eisenberg S , Sehayek E , Olivecrona T , Vlodavsky I |
Ref : J Clinical Investigation , 90 :2013 , 1992 |
Abstract : Eisenberg_1992_J.Clin.Invest_90_2013 |
ESTHER : Eisenberg_1992_J.Clin.Invest_90_2013 |
PubMedSearch : Eisenberg_1992_J.Clin.Invest_90_2013 |
PubMedID: 1430223 |
Title : A missense mutation at codon 188 of the human lipoprotein lipase gene is a frequent cause of lipoprotein lipase deficiency in persons of different ancestries - Monsalve_1990_J.Clin.Invest_86_728 |
Author(s) : Monsalve MV , Henderson H , Roederer G , Julien P , Deeb S , Kastelein JJ , Peritz L , Devlin R , Bruin T , Murthy MR , et al. |
Ref : J Clinical Investigation , 86 :728 , 1990 |
Abstract : Monsalve_1990_J.Clin.Invest_86_728 |
ESTHER : Monsalve_1990_J.Clin.Invest_86_728 |
PubMedSearch : Monsalve_1990_J.Clin.Invest_86_728 |
PubMedID: 1975597 |
Gene_locus related to this paper: human-LPL |
Title : Human lipoprotein lipase complementary DNA sequence - Wion_1987_Science_235_1638 |
Author(s) : Wion KL , Kirchgessner TG , Lusis AJ , Schotz MC , Lawn RM |
Ref : Science , 235 :1638 , 1987 |
Abstract : Wion_1987_Science_235_1638 |
ESTHER : Wion_1987_Science_235_1638 |
PubMedSearch : Wion_1987_Science_235_1638 |
PubMedID: 3823907 |
Gene_locus related to this paper: human-LPL |
Structures (6)
Genes Proteins in Lipoprotein_Lipase family (318)
Fragments of genes in Lipoprotein_Lipase family (66)
Structures in Lipoprotein_Lipase family (6)Substrates in Lipoprotein_Lipase family (3)
Inhibitors in Lipoprotein_Lipase family (7)