Maspardin-ACP33-SPG21_like
Relationship
Comment
ACP33 binds the intracellular domain of CD4. Mutation S109A abolishes the interraction. S109 is in similar position as active site serine of a/b hydrolase. Maspardin-ACP33-SPG21 gene is mutated in Mast Syndrome (Cross and McKusick 1967, Simpson et al 2003), a Complicated Form of hereditary spastic paraplegia associated with dementia. Ishiura et al. (2014) reported 2 Japanese brothers with autosomal recessive SPG21. The patients had onset of gait disturbances in their fifties and sixties, much later than that reported by Cross and McKusick (1967). Maspardin is conserved in metazoans but independent losses of this gene occured in two relatively distant ecdysozoan taxa: dipterans and nematodes (Chertemps et al.). Extracellular vesicles from Echinococcus granulosus (Platyhelminthe-Cestode) larval stage contain an orthologue of maspardin (Nicolao 2019). A Novel alpha/beta-hydrolase gene IbMa, homologous to maspardin, enhances salt tolerance in transgenic Sweetpotato (Liu et al. 2014) OsMas1 in rice (Wang et al. 2022)Database
Interpro : IPR000073 Alpha\/beta hydrolase fold-1 , IPR026151 Maspardin
PIRSF : No PIRSF
Pdoc : No Pdoc
Pfam : PF12697 Abhydrolase_6
Prints : No Print
EC Number : No EC Number
References (14)
| Title : OsMas1, a novel maspardin protein gene, confers the tolerance to salt and drought stresses by regulating ABA signaling in rice - Wang_2022_J.Integr.Agric__ |
| Author(s) : Wang FB , Wan CZ , Niu HF , Qi MY , Li G , Zhang F , Hu LB , Ye YX , Wang ZX , Pei BL , Chen XH , Yuan CY |
| Ref : J.Integr.Agric , : , 2022 |
| Abstract : Wang_2022_J.Integr.Agric__ |
| ESTHER : Wang_2022_J.Integr.Agric__ |
| PubMedSearch : Wang_2022_J.Integr.Agric__ |
| PubMedID: |
| Gene_locus related to this paper: orysa-q33aq0 |
| Title : Extracellular vesicles from Echinococcus granulosus larval stage: Isolation, characterization and uptake by dendritic cells - Nicolao_2019_PLoS.Negl.Trop.Dis_13_e0007032 |
| Author(s) : Nicolao MC , Rodriguez Rodrigues C , Cumino AC |
| Ref : PLoS Negl Trop Dis , 13 :e0007032 , 2019 |
| Abstract : Nicolao_2019_PLoS.Negl.Trop.Dis_13_e0007032 |
| ESTHER : Nicolao_2019_PLoS.Negl.Trop.Dis_13_e0007032 |
| PubMedSearch : Nicolao_2019_PLoS.Negl.Trop.Dis_13_e0007032 |
| PubMedID: 30615613 |
| Gene_locus related to this paper: echgr-w6u7y4 |
| Title : Loss of Maspardin Attenuates the Growth and Maturation of Mouse Cortical Neurons - Davenport_2016_Neurodegener.Dis_16_260 |
| Author(s) : Davenport A , Bivona A , Latson W , Lemanski LF , Cheriyath V |
| Ref : Neurodegener Dis , 16 :260 , 2016 |
| Abstract : Davenport_2016_Neurodegener.Dis_16_260 |
| ESTHER : Davenport_2016_Neurodegener.Dis_16_260 |
| PubMedSearch : Davenport_2016_Neurodegener.Dis_16_260 |
| PubMedID: 26978163 |
| Title : A Novel alpha\/beta-Hydrolase Gene IbMas Enhances Salt Tolerance in Transgenic Sweetpotato - Liu_2014_PLoS.One_9_e115128 |
| Author(s) : Liu D , Wang L , Zhai H , Song X , He S , Liu Q |
| Ref : PLoS ONE , 9 :e115128 , 2014 |
| Abstract : Liu_2014_PLoS.One_9_e115128 |
| ESTHER : Liu_2014_PLoS.One_9_e115128 |
| PubMedSearch : Liu_2014_PLoS.One_9_e115128 |
| PubMedID: 25501819 |
| Gene_locus related to this paper: ipoba-a0a076l3m2 |
| Title : Molecular epidemiology and clinical spectrum of hereditary spastic paraplegia in the Japanese population based on comprehensive mutational analyses - Ishiura_2014_J.Hum.Genet_59_163 |
| Author(s) : Ishiura H , Takahashi Y , Hayashi T , Saito K , Furuya H , Watanabe M , Murata M , Suzuki M , Sugiura A , Sawai S , Shibuya K , Ueda N , Ichikawa Y , Kanazawa I , Goto J , Tsuji S |
| Ref : J Hum Genet , 59 :163 , 2014 |
| Abstract : Ishiura_2014_J.Hum.Genet_59_163 |
| ESTHER : Ishiura_2014_J.Hum.Genet_59_163 |
| PubMedSearch : Ishiura_2014_J.Hum.Genet_59_163 |
| PubMedID: 24451228 |
| Gene_locus related to this paper: human-SPG21 |
| Title : Characterization of maspardin, responsible for human Mast syndrome, in an insect species and analysis of its evolution in metazoans - Chertemps_2012_Naturwiss_99_537 |
| Author(s) : Chertemps T , Montagne N , Bozzolan F , Maria A , Durand N , Maibeche-Coisne M |
| Ref : Naturwissenschaften , 99 :537 , 2012 |
| Abstract : Chertemps_2012_Naturwiss_99_537 |
| ESTHER : Chertemps_2012_Naturwiss_99_537 |
| PubMedSearch : Chertemps_2012_Naturwiss_99_537 |
| PubMedID: 22729480 |
| Gene_locus related to this paper: spoli-a0a023pts0 |
| Title : Hereditary spastic paraplegias with autosomal dominant, recessive, X-linked, or maternal trait of inheritance - Finsterer_2012_J.Neurol.Sci_318_1 |
| Author(s) : Finsterer J , Loscher W , Quasthoff S , Wanschitz J , Auer-Grumbach M , Stevanin G |
| Ref : Journal of Neurology Sci , 318 :1 , 2012 |
| Abstract : Finsterer_2012_J.Neurol.Sci_318_1 |
| ESTHER : Finsterer_2012_J.Neurol.Sci_318_1 |
| PubMedSearch : Finsterer_2012_J.Neurol.Sci_318_1 |
| PubMedID: 22554690 |
| Gene_locus related to this paper: human-SPG21 |
| Title : [Study of the effect and mechanism of spastic paraplegia 21 protein on the replication of hepatitis B virus] - Gao_2011_Zhonghua.Gan.Zang.Bing.Za.Zhi_19_747 |
| Author(s) : Gao GS , Weng PJ , Li RY , Ding SX |
| Ref : Zhonghua Gan Zang Bing Za Zhi , 19 :747 , 2011 |
| Abstract : Gao_2011_Zhonghua.Gan.Zang.Bing.Za.Zhi_19_747 |
| ESTHER : Gao_2011_Zhonghua.Gan.Zang.Bing.Za.Zhi_19_747 |
| PubMedSearch : Gao_2011_Zhonghua.Gan.Zang.Bing.Za.Zhi_19_747 |
| PubMedID: 22409846 |
| Gene_locus related to this paper: human-SPG21 |
| Title : Targeted disruption of the Mast syndrome gene SPG21 in mice impairs hind limb function and alters axon branching in cultured cortical neurons - Soderblom_2010_Neurogenetics_11_369 |
| Author(s) : Soderblom C , Stadler J , Jupille H , Blackstone C , Shupliakov O , Hanna MC |
| Ref : Neurogenetics , 11 :369 , 2010 |
| Abstract : Soderblom_2010_Neurogenetics_11_369 |
| ESTHER : Soderblom_2010_Neurogenetics_11_369 |
| PubMedSearch : Soderblom_2010_Neurogenetics_11_369 |
| PubMedID: 20661613 |
| Gene_locus related to this paper: human-SPG21 , mouse-SPG21 |
| Title : Interaction of the SPG21 protein ACP33\/maspardin with the aldehyde dehydrogenase ALDH16A1 - Hanna_2009_Neurogenetics_10_217 |
| Author(s) : Hanna MC , Blackstone C |
| Ref : Neurogenetics , 10 :217 , 2009 |
| Abstract : Hanna_2009_Neurogenetics_10_217 |
| ESTHER : Hanna_2009_Neurogenetics_10_217 |
| PubMedSearch : Hanna_2009_Neurogenetics_10_217 |
| PubMedID: 19184135 |
| Gene_locus related to this paper: human-SPG21 , mouse-SPG21 |
| Title : Differential brain transcriptome of beta4 nAChR subunit-deficient mice: is it the effect of the null mutation or the background strain? - Kedmi_2007_Physiol.Genomics_28_213 |
| Author(s) : Kedmi M , Orr-Urtreger A |
| Ref : Physiol Genomics , 28 :213 , 2007 |
| Abstract : Kedmi_2007_Physiol.Genomics_28_213 |
| ESTHER : Kedmi_2007_Physiol.Genomics_28_213 |
| PubMedSearch : Kedmi_2007_Physiol.Genomics_28_213 |
| PubMedID: 16985005 |
| Gene_locus related to this paper: human-SPG21 |
| Title : Maspardin is mutated in mast syndrome, a complicated form of hereditary spastic paraplegia associated with dementia - Simpson_2003_Am.J.Hum.Genet_73_1147 |
| Author(s) : Simpson MA , Cross H , Proukakis C , Pryde A , Hershberger R , Chatonnet A , Patton MA , Crosby AH |
| Ref : American Journal of Human Genetics , 73 :1147 , 2003 |
| Abstract : Simpson_2003_Am.J.Hum.Genet_73_1147 |
| ESTHER : Simpson_2003_Am.J.Hum.Genet_73_1147 |
| PubMedSearch : Simpson_2003_Am.J.Hum.Genet_73_1147 |
| PubMedID: 14564668 |
| Gene_locus related to this paper: human-SPG21 |
| Title : Cloning of ACP33 as a novel intracellular ligand of CD4 - Zeitlmann_2001_J.Biol.Chem_276_9123 |
| Author(s) : Zeitlmann L , Sirim P , Kremmer E , Kolanus W |
| Ref : Journal of Biological Chemistry , 276 :9123 , 2001 |
| Abstract : Zeitlmann_2001_J.Biol.Chem_276_9123 |
| ESTHER : Zeitlmann_2001_J.Biol.Chem_276_9123 |
| PubMedSearch : Zeitlmann_2001_J.Biol.Chem_276_9123 |
| PubMedID: 11113139 |
| Gene_locus related to this paper: human-SPG21 , mouse-SPG21 |
| Title : The mast syndrome. A recessively inherited form of presenile dementia with motor disturbances - |
| Author(s) : Cross HE , McKusick VA |
| Ref : Archives of Neurology , 16 :1 , 1967 |
| PubMedID: 6024251 |
| Gene_locus related to this paper: human-SPG21 |
No structure scheme yet for this family
Genes Proteins in Maspardin-ACP33-SPG21_like family (150)
Fragments of genes in Maspardin-ACP33-SPG21_like family (25)
No fragment of genesNo substrate
No Inhibitor