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Family Report for: Ndr_family

Ndr_family



Relationship
Family Ndr_family
Block X
Comment
RTP/Drg1/Ndr1 genes are repressed by the proto-oncogenes N-myc and c-myc. Members of this family are found in wide variety of multicellular eukaryotes, including plants (ndr nothing to do with nodal-related genes) Ndr1 included in alpha/beta hydolase PF00561 now have a Pfam family PF03096. Shaw et al Proteins 2002 May 1;47(2):163-8 identified this family as alpha/beta hydrolase. Kalaydjieva et al. showed that human-NDRG1 is mutated in hereditary motor and sensory neuropathy-Lom . Bhaduri et al. showed that ratno-ndr4 (Bdm1) is associated with hot water epilepsy. Mitchelmore et al. showed that NDRG2 is upregulated in Alzheimer's disease. NDRG1 facilitates lytic replication of Kaposi's sarcoma-associated herpesvirus by maintaining the stability of the KSHV helicase as published by Dong et al.
2 Disease(s)


Database
Sequences
Interpro
|
IPR004142 (NDRG), IPR030693 (Protein NDRG1), IPR030690 (Protein NDRG2), IPR030692 (Protein NDRG3), IPR030695 (Protein NDRG4)
PIRSF
|
Pdoc
|
PFam
|
PF03096 (Ndr)
Prints
|
Prosite
|
no EC number



Peptide in
|Fasta
Nucleotide in
|Fasta
Alignment with Multalin
|Text only/graphic display
Seed alignment with MAFFT
|No colour/coloured with Mview
Alignment with MAFFT
|No colour/coloured with Mview
Dendrogram
|Graphical display, obtained with the dnd file produced by Clustalw

References
10 more
    Title: NDRG1 facilitates lytic replication of Kaposi's sarcoma-associated herpesvirus by maintaining the stability of the KSHV helicase
    Dong L, Dong J, Xiang M, Lei P, Li Z, Zhang F, Sun X, Niu D, Bai L, Lan K
    Ref: PLoS Pathog, 17:e1009645, 2021 : PubMed

            

    Title: Differential expression and hypoxia-mediated regulation of the N-myc downstream regulated gene family
    Le N, Hufford TM, Park JS, Brewster RM
    Ref: FASEB Journal, 35:e21961, 2021 : PubMed

            

    Title: The Role of N-myc Downstream-Regulated Gene Family in Glioma Based on Bioinformatics Analysis
    Tang T, Wang H, Han Y, Huang H, Niu W, Fei M, Zhu Y
    Ref: DNA & Cell Biology, 40:949, 2021 : PubMed

            

Other Papers


No structure scheme yet for this family

Structures in Ndr_family family (8)

Genes Proteins in Ndr_family family (258)

Fragments of genes in Ndr_family family (57)

No Substrate

No Inhibitor



Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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