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Family Report for: Pancreatic_lipase


Block L
Pancreatic, hepatic and gastric/lingual lipase are closely related to each other and to lipoprotein lipase (EC:, which hydrolyses triglycerides of chylomicrons and very low density lipoproteins (VLDL). Pancreatic lipase (triacylglycerol acylhydrolase, EC: plays a key role in dietary fat absorption by hydrolysing dietary long chain triacyl-glycerol to free fatty acids and monoacylglycerols in the intestinal lumen. The activity of lipase is stimulated by colipase in the presence of bile acids. Congenital pancreatic lipase deficiency is a rare, monoenzymatic form of exocrine pancreatic failure. Patients have oily/greasy stools from infancy or early childhood and the absence of discernable pancreatic disease. The pancreatic lipase-related protein show no significant catalytic activity on any of the substrates tested di and tri-glycerides phospholipids. Introducing the double mutation Val 178 Ala and Ala 180 Pro into the human pancreatic RP1 HPLRP1 gene yielded an enzyme is kinetically active on triglycerides. The guinea pig pancreatic lipase-related protein 2 (GPLRP2) differs from classical pancreatic lipases in that it displays both lipase and phospholipase A1 activities; classical pancreatic lipases have no phospholipase activity. human-PNLIPRP2 adopt in solution an open lid conformation which creates a large cavity capable of accommodating the galactose polar head of galactolipids (galactolipase)
1 Disease(s)

IPR000734 (Lipase), IPR002331 (Pancreatic lipase), IPR016272 (Lipase, LIPH-type)
PF00151 (Lipase)

Peptide in
Nucleotide in
Alignment with Multalin
|Text only/graphic display
Seed alignment with MAFFT
|No colour/coloured with Mview
Alignment with MAFFT
|No colour/coloured with Mview
|Graphical display, obtained with the dnd file produced by Clustalw

11 more
    Title: Structure of human pancreatic lipase-related protein 2 with the lid in an open conformation
    Eydoux C, Spinelli S, Davis TL, Walker JR, Seitova A, Dhe-Paganon S, de Caro A, Cambillau C, Carriere F
    Ref: Biochemistry, 47:9553, 2008 : PubMed


    Title: Reactivation of the totally inactive pancreatic lipase RP1 by structure-predicted point mutations
    Roussel A, De Caro J, Bezzine S, Gastinel L, de Caro A, Carriere F, Leydier S, Verger R, Cambillau C
    Ref: Proteins, 32:523, 1998 : PubMed


    Title: Minireview on pancreatic lipase and colipase
    Chapus C, Rovery M, Sarda L, Verger R
    Ref: Biochimie, 70:1223, 1988 : PubMed


Other Papers

No structure scheme yet for this family

Structures in Pancreatic_lipase family (12)

Genes Proteins in Pancreatic_lipase family (488)

Fragments of genes in Pancreatic_lipase family (103)

Substrates of some enzymes in the Pancreatic_lipase family (17)

Inhibitors of some enzymes in the Pancreatic_lipase family (14)

Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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