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Family Report for: Pectinacetylesterase-Notum

Pectinacetylesterase-Notum



Relationship
Block X

Database
Sequences
Interpro
|
IPR004963 (Pectinacetylesterase/NOTUM PAE/NOTUM)
PIRSF
|
Pdoc
|
PFam
|
PF03283 (PAE)
Prints
|
Prosite
|
no EC number



Peptide in
|Fasta
Nucleotide in
|Fasta
Alignment with Multalin
|Text only/graphic display
Seed alignment with MAFFT
|No colour/coloured with Mview
Alignment with MAFFT
|No colour/coloured with Mview
Dendrogram
|Graphical display, obtained with the dnd file produced by Clustalw

References
21 more
    Title: Virtual Screening Directly Identifies New Fragment-Sized Inhibitors of Carboxylesterase Notum with Nanomolar Activity
    Steadman D, Atkinson BN, Zhao Y, Willis NJ, Frew S, Monaghan A, Patel C, Armstrong E, Costelloe K and Svensson F <4 more author(s)>
    Ref: Journal of Medicinal Chemistry, 65:562, 2022 : PubMed

            

    Title: Design of a potent, selective and brain penetrant inhibitor of Wnt-deactivating enzyme Notum by optimization of a crystallographic fragment hit
    Willis NJ, Mahy W, Sipthorp J, Zhao Y, Woodward HL, Atkinson BN, Bayle ED, Svensson F, Frew S and Fish PV <14 more author(s)>
    Ref: Journal of Medicinal Chemistry, :, 2022 : PubMed

            

    Title: Notum Deacylates Octanoylated Ghrelin
    Zhao Y, Schuhmacher LN, Roberts M, Kakugawa S, Bineva-Todd G, Howell S, O'Reilly N, Perret C, Snijders AP and Jones EY <1 more author(s)>
    Ref: Mol Metab, :101201, 2021 : PubMed

            

Other Papers


No structure scheme yet for this family

Structures in Pectinacetylesterase-Notum family (129)

Genes Proteins in Pectinacetylesterase-Notum family (695)

Fragments of genes in Pectinacetylesterase-Notum family (201)

Substrates of some enzymes in the Pectinacetylesterase-Notum family (6)

Inhibitors of some enzymes in the Pectinacetylesterase-Notum family (121)



Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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