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Family Report for: Peptidase_S9

Peptidase_S9



Relationship
Block X


Comment
Previously called Prolyl_oligopeptidase_S9 (but are not only prolyl peptidase) Peptidase_S9 are serine protease of the clan S family S9 in MEROPS database. It contains: - prolyl oligopeptidase (EC 3.4.21.26) (also called post-proline cleaving enzyme);- Escherichia coli protease II (EC 3.4.21.83) (oligopeptidase B) (gene prtB);- dipeptidyl petidase IV related proteins(EC 3.4.14.5) (DPP IV) important for the activation or inactivation of extracellular endocrine paracrine and autocrine peptides. DPPIV is synonymous with CD26 (important in HIV infection). Some members lack active serine and are probably not enzymes. The prototype structure has a beta propeller which guide substrates to the active site;- Yeast vacuolar dipeptidyl aminopeptidase A;- Acylamino-acid-releasing enzyme (EC 3.4.19.1) (acyl-peptide hydrolase).
5 Disease(s)
Hatipoglu syndrome from mutation Q851X_human-DPP9 in gene_locus human-DPP9.


Database
Sequences
Interpro
|
IPR002469 (Peptidase S9B, dipeptidylpeptidase IV N-terminal), IPR001375 (Peptidase S9, prolyl oligopeptidase active site region), IPR002470 (Peptidase S9A, prolyl oligopeptidase), IPR002471 (Peptidase S9, serine active site)
PIRSF
|
Pdoc
|
PFam
|
PF00326 (Peptidase_S9), PF00930 (DPPIV_N)
Prints
|
Prosite
|
EC at KEGG
|
EC at EXPASY
|


Peptide in
|Fasta
Nucleotide in
|Fasta
Alignment with Multalin
|Text only/graphic display
Seed alignment with MAFFT
|No colour/coloured with Mview
Alignment with MAFFT
|No colour/coloured with Mview
Dendrogram
|Graphical display, obtained with the dnd file produced by Clustalw

References
3 more
    Title: The prolyl oligopeptidase family
    Polgar L
    Ref: Cell Mol Life Sciences, 59:349, 2002 : PubMed

            

    Title: Families of serine peptidases
    Rawlings ND, Barrett AJ
    Ref: Methods Enzymol, 244:19, 1994 : PubMed

            

    Title: Structural relationship between lipases and peptidases of the prolyl oligopeptidase family
    Polgar L
    Ref: FEBS Letters, 311:281, 1992 : PubMed

            

Other Papers


Structure scheme for Peptidase_S9

Structures in Peptidase_S9 family (289)

Genes Proteins in Peptidase_S9 family (1960)

Fragments of genes in Peptidase_S9 family (61)

No Substrate

No Inhibitor



Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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