Peptidase_S9
Relationship
Comment
Previously called Prolyl_oligopeptidase_S9 (but are not only prolyl peptidase) Peptidase_S9 are serine protease of the clan S family S9 in MEROPS database. It contains: - prolyl oligopeptidase (EC 3.4.21.26) (also called post-proline cleaving enzyme);- Escherichia coli protease II (EC 3.4.21.83) (oligopeptidase B) (gene prtB);- dipeptidyl petidase IV related proteins(EC 3.4.14.5) (DPP IV) important for the activation or inactivation of extracellular endocrine paracrine and autocrine peptides. DPPIV is synonymous with CD26 (important in HIV infection). Some members lack active serine and are probably not enzymes. The prototype structure has a beta propeller which guide substrates to the active site;- Yeast vacuolar dipeptidyl aminopeptidase A;- Acylamino-acid-releasing enzyme (EC 3.4.19.1) (acyl-peptide hydrolase).Database
Interpro : IPR002469 Peptidase S9B, dipeptidylpeptidase IV N-terminal , IPR001375 Peptidase S9, prolyl oligopeptidase active site region , IPR002470 Peptidase S9A, prolyl oligopeptidase , IPR002471 Peptidase S9, serine active site
PIRSF : No PIRSF
Pdoc : PDOC00587
Pfam : PF00326 Peptidase_S9 , PF00930 DPPIV_N
Prints : No Print
EC Number : 3.4.14.5 || 3.4.19.1 || 3.4.21.26 || 3.4.21.83
References (6)
| Title : The dipeptidyl peptidase IV family in cancer and cell biology - Yu_2010_FEBS.J_277_1126 |
| Author(s) : Yu DM , Yao TW , Chowdhury S , Nadvi NA , Osborne B , Church WB , McCaughan GW , Gorrell MD |
| Ref : Febs J , 277 :1126 , 2010 |
| Abstract : Yu_2010_FEBS.J_277_1126 |
| ESTHER : Yu_2010_FEBS.J_277_1126 |
| PubMedSearch : Yu_2010_FEBS.J_277_1126 |
| PubMedID: 20074209 |
| Title : Cloning and characterization of dipeptidyl peptidase 10, a new member of an emerging subgroup of serine proteases - Qi_2003_Biochem.J_373_179 |
| Author(s) : Qi SY , Riviere PJ , Trojnar J , Junien JL , Akinsanya KO |
| Ref : Biochemical Journal , 373 :179 , 2003 |
| Abstract : Qi_2003_Biochem.J_373_179 |
| ESTHER : Qi_2003_Biochem.J_373_179 |
| PubMedSearch : Qi_2003_Biochem.J_373_179 |
| PubMedID: 12662155 |
| Gene_locus related to this paper: human-DPP8 , human-DPP9 , human-DPP10 , mouse-dpp9 , mouse-dpp10 |
| Title : The prolyl oligopeptidase family - Polgar_2002_Cell.Mol.Life.Sci_59_349 |
| Author(s) : Polgar L |
| Ref : Cell Mol Life Sciences , 59 :349 , 2002 |
| Abstract : Polgar_2002_Cell.Mol.Life.Sci_59_349 |
| ESTHER : Polgar_2002_Cell.Mol.Life.Sci_59_349 |
| PubMedSearch : Polgar_2002_Cell.Mol.Life.Sci_59_349 |
| PubMedID: 11915948 |
| Title : Catalysis of serine oligopeptidases is controlled by a gating filter mechanism - Fulop_2000_EMBO.Rep_1_277 |
| Author(s) : Fulop V , Szeltner Z , Polgar L |
| Ref : EMBO Rep , 1 :277 , 2000 |
| Abstract : Fulop_2000_EMBO.Rep_1_277 |
| ESTHER : Fulop_2000_EMBO.Rep_1_277 |
| PubMedSearch : Fulop_2000_EMBO.Rep_1_277 |
| PubMedID: 11256612 |
| Gene_locus related to this paper: pig-ppce |
| Title : Families of serine peptidases - |
| Author(s) : Rawlings ND , Barrett AJ |
| Ref : Methods Enzymol , 244 :19 , 1994 |
| PubMedID: 7845208 |
| Title : Structural relationship between lipases and peptidases of the prolyl oligopeptidase family - Polgar_1992_FEBS.Lett_311_281 |
| Author(s) : Polgar L |
| Ref : FEBS Letters , 311 :281 , 1992 |
| Abstract : Polgar_1992_FEBS.Lett_311_281 |
| ESTHER : Polgar_1992_FEBS.Lett_311_281 |
| PubMedSearch : Polgar_1992_FEBS.Lett_311_281 |
| PubMedID: 1397329 |
No structure scheme yet for this family
No Genes Proteins
No fragment of genes
No fragment of genesNo substrate
No Inhibitor