Family

Go to basket

Tree Display

AceDB Schema

XML Display

Feedback

Family Report for: Phospholipase

Phospholipase



Relationship
Block L
Comment
Phospholipase A(1) (PLA(1)) is an enzyme that hydrolyzes phospholipids and produces 2-acyl-lysophospholipids and fatty acids and is conserved in a wide range of organisms. Hypotrichosis, or woolly hair with or without hypotrichosis hypotrichosis (deficiency of hair growth), can be caused by homozygous or compound heterozygous mutation in the LIPH (human-LIPH) gene on chromosome 3q27 (not hepatic lipase: human-LIPC). Other mammalian enzymes that exhibit PLA(1) activity in vitro are hepatic lipase HL endothelial lipase EL and pancreatic lipase-related protein 2 PLRP2 and belong to alpha/beta hydrolase superfamily.
2 Disease(s)
Hypotrichosis from mutation Delexon4_human-LIPH in gene_locus human-LIPH.


Database
Sequences
Interpro
|
IPR000734 (Lipase), IPR002334 (Dol/Ves 1 allergen), IPR016272 (Lipase, LIPH-type), IPR013818 (Lipase)
PIRSF
|
Pdoc
|
PFam
|
PF00151 (Lipase)
Prints
|
Prosite
|
EC at KEGG
|
EC at EXPASY
|


Peptide in
|Fasta
Nucleotide in
|Fasta
Alignment with Multalin
|Text only/graphic display
Seed alignment with MAFFT
|No colour/coloured with Mview
Alignment with MAFFT
|No colour/coloured with Mview
Dendrogram
|Graphical display, obtained with the dnd file produced by Clustalw

References
    Title: The Lysophosphatidylserines-An Emerging Class of Signalling Lysophospholipids
    Shanbhag K, Mhetre A, Khandelwal N, Kamat SS
    Ref: J Membr Biol, 253:381, 2020 : PubMed

            

    Title: Structure and function of extracellular phospholipase A1 belonging to the pancreatic lipase gene family
    Aoki J, Inoue A, Makide K, Saiki N, Arai H
    Ref: Biochimie, 89:197, 2007 : PubMed

            

    Title: An alternative splicing form of phosphatidylserine-specific phospholipase A1 that exhibits lysophosphatidylserine-specific lysophospholipase activity in humans
    Nagai Y, Aoki J, Sato T, Amano K, Matsuda Y, Arai H and
    Ref: Journal of Biological Chemistry, 274:11053, 1999 : PubMed

            

Other Papers


No structure scheme yet for this family

No Structure yet in this family

Genes Proteins in Phospholipase family (277)

Fragments of genes in Phospholipase family (19)

Substrates of some enzymes in the Phospholipase family (5)

No Inhibitor



Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
For technical information about these pages see:
ESTHER Home Page and ACEDB Home Page
AcePerl Lincoln Stein Home Page
webmaster

Acknowledgements and disclaimer