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Family Report for: S9N_PREPL_Peptidase_S9

S9N_PREPL_Peptidase_S9



Relationship
Block X
Parent Family : Peptidase_S9

Comment
a prolyl endopeptidase-like enzyme by name only; a (thio)esterase involved in mitochondrial respiratory chain function (Rosier et al.). PREPL Prolylendopeptidase-like. Prolyl oligopeptidase (EC 3.4.21.26) (also called post-proline cleaving enzyme). N-terminal domain is a 7-bladed beta-propeller. In contrast to PREP and oligopeptidase B, which require both amino- and carboxy-terminal sequences for activity, PREPL activity appeared to depend only on the carboxy-terminal domain. Deletion of PREPL was found in patients with hypotonia-cystinuria syndrome Parvari et al. (2001, 2005) Jaeken et al. (2006)
1 Disease(s)


Database
Sequences
Interpro
|
IPR004106 (Peptidase S9A/B/C, oligopeptidase, N-terminal beta-propeller), IPR001375 (Peptidase_S9)
PIRSF
|
Pdoc
|
PFam
|
PF00326 (Peptidase_S9), PF02897 (Peptidase_S9_N)
Prints
|
Prosite
|
no EC number



Peptide in
|Fasta
Nucleotide in
|Fasta
Alignment with Multalin
|Text only/graphic display
Seed alignment with MAFFT
|No colour/coloured with Mview
Alignment with MAFFT
|No colour/coloured with Mview
Dendrogram
|Graphical display, obtained with the dnd file produced by Clustalw

References
18 more
    Title: Prolyl endopeptidase-like is a (thio)esterase involved in mitochondrial respiratory chain function
    Rosier K, McDevitt MT, Smet J, Floyd BJ, Verschoore M, Marcaida MJ, Bingman CA, Lemmens I, Dal Peraro M and Creemers JWM <12 more author(s)>
    Ref: iScience, 24:103460, 2021 : PubMed

            

    Title: PREPL, a prolyl endopeptidase-like enzyme by name only?--Lessons from patients
    Boonen K, Regal L, Jaeken J, Creemers JW
    Ref: CNS Neurol Disord Drug Targets, 10:355, 2011 : PubMed

            

    Title: Prolyl oligopeptidase: an unusual beta-propeller domain regulates proteolysis
    Fulop V, Bocskei Z, Polgar L
    Ref: Cell, 94:161, 1998 : PubMed

            

Other Papers


No structure scheme yet for this family

Structures in S9N_PREPL_Peptidase_S9 family (9)

Genes Proteins in S9N_PREPL_Peptidase_S9 family (204)

Fragments of genes in S9N_PREPL_Peptidase_S9 family (6)

Substrates of some enzymes in the S9N_PREPL_Peptidase_S9 family (9)

Inhibitors of some enzymes in the S9N_PREPL_Peptidase_S9 family (12)



Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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