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Family Report for: T6SS-TLE1


Family T6SS-TLE1
Block X
The type VI lipase effectors Tle1-Tle5 secreted by the bacterial type VI secretion system (T6SS) have recently been identified as antibacterial effectors that hydrolyze membrane phospholipids. The Tle1-4 display phospholipase A1 and A2 (PLA1) (PLA2) activities. Tle1 belongs to Duf_2235 (T6SS-TLE1) family, TLE2 to Lipase_3, TLE3 to alpha/ beta hydrolase(now the family (T6SS-TLE3) and Tle4 belongs to PGAP1. The adjacent genes code for VgrG proteins and putative periplasmic immunity proteins Tle5 are unrelated phospholipase D type. The bacterial type VI secretion system (T6SS) is a macromolecular machine that injects effectors into prokaryotic and eukaryotic cells. In enteroaggregative Escherichia coli, the Tle1 phospholipase binds the C-terminal extension of the VgrG trimeric spike. The inhibition of Tle1 phospholipase activity once bound to VgrG suggests that Tle1 dissociation from VgrG is required upon delivery

IPR018712 (Protein of unknown function DUF2235)
PF09994 (DUF2235)
no EC number

Peptide in
Nucleotide in
Alignment with Multalin
|Text only/graphic display
Seed alignment with MAFFT
|No colour/coloured with Mview
Alignment with MAFFT
|No colour/coloured with Mview
|Graphical display, obtained with the dnd file produced by Clustalw

1 more
    Title: The phospholipase effector Tle1(Vc) promotes Vibrio cholerae virulence by killing competitors and impacting gene expression
    Liu M, Wang H, Liu Y, Tian M, Wang Z, Shu RD, Zhao MY, Chen WD, Fu Y
    Ref: Gut Microbes, 15:2241204, 2023 : PubMed


    Title: Structure of the type VI secretion phospholipase effector Tle1 provides insight into its hydrolysis and membrane targeting
    Hu H, Zhang H, Gao Z, Wang D, Liu G, Xu J, Lan K, Dong Y
    Ref: Acta Crystallographica D Biol Crystallogr, 70:2175, 2014 : PubMed


    Title: Diverse type VI secretion phospholipases are functionally plastic antibacterial effectors
    Russell AB, LeRoux M, Hathazi K, Agnello DM, Ishikawa T, Wiggins PA, Wai SN, Mougous JD
    Ref: Nature, 496:508, 2013 : PubMed


Other Papers

No structure scheme yet for this family

Structures in T6SS-TLE1 family (3)

Genes Proteins in T6SS-TLE1 family (33)

Fragments of genes in T6SS-TLE1 family (1)

Substrates of some enzymes in the T6SS-TLE1 family (1)

No Inhibitor

Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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