Interpro : IPR001031 Thioesterase , IPR012223 Thioesterase type II, NRPS\/PKS\/S-FAS TEII , IPR023102 Fatty acid synthase, domain 2 Fatty_acid_synthase_dom_2 , IPR011412 Coronamic acid biosynthesis thioesterase CmaT , IPR020802 Polyketide synthase, thioesterase domain , IPR012367 Uncharacterised conserved protein thioesterase UCP_Testerase
PIRSF : No PIRSF
Pdoc : No Pdoc
Pfam : PF00975 Thioesterase
Prints : No Print
EC Number : No EC Number
Title : Structural and Mechanistic Insights into Chain Release of the Polyene PKS Thioesterase Domain - Zhou_2022_ACS.Catal_12_762 |
Author(s) : Zhou Y , Tao W , Qi Z , Wei J , Shi T , Kang Q , Zheng J , Zhao Y , Bai L |
Ref : ACS Catal , 12 :762 , 2022 |
Abstract : Zhou_2022_ACS.Catal_12_762 |
ESTHER : Zhou_2022_ACS.Catal_12_762 |
PubMedSearch : Zhou_2022_ACS.Catal_12_762 |
PubMedID: |
Gene_locus related to this paper: 9actn-f1cla7 |
Title : Chain release mechanisms in polyketide and non-ribosomal peptide biosynthesis - Little_2022_Nat.Prod.Rep_39_163 |
Author(s) : Little RF , Hertweck C |
Ref : Nat Prod Rep , 39 :163 , 2022 |
Abstract : Little_2022_Nat.Prod.Rep_39_163 |
ESTHER : Little_2022_Nat.Prod.Rep_39_163 |
PubMedSearch : Little_2022_Nat.Prod.Rep_39_163 |
PubMedID: 34622896 |
Title : Thioesterase enzyme families: Functions, structures, and mechanisms - Caswell_2021_Protein.Sci__ |
Author(s) : Caswell BT , de Carvalho CC , Nguyen H , Roy M , Nguyen T , Cantu DC |
Ref : Protein Science , : , 2021 |
Abstract : Caswell_2021_Protein.Sci__ |
ESTHER : Caswell_2021_Protein.Sci__ |
PubMedSearch : Caswell_2021_Protein.Sci__ |
PubMedID: 34921469 |
Title : Trapping biosynthetic acyl-enzyme intermediates with encoded 2,3-diaminopropionic acid - Huguenin-Dezot_2019_Nature_565_112 |
Author(s) : Huguenin-Dezot N , Alonzo DA , Heberlig GW , Mahesh M , Nguyen DP , Dornan MH , Boddy CN , Schmeing TM , Chin JW |
Ref : Nature , 565 :112 , 2019 |
Abstract : Huguenin-Dezot_2019_Nature_565_112 |
ESTHER : Huguenin-Dezot_2019_Nature_565_112 |
PubMedSearch : Huguenin-Dezot_2019_Nature_565_112 |
PubMedID: 30542153 |
Gene_locus related to this paper: 9acto-q1psf3 |
Title : Polyketide synthase and non-ribosomal peptide synthetase thioesterase selectivity: logic gate or a victim of fate? - Horsman_2016_Nat.Prod.Rep_33_183 |
Author(s) : Horsman ME , Hari TP , Boddy CN |
Ref : Nat Prod Rep , 33 :183 , 2016 |
Abstract : Horsman_2016_Nat.Prod.Rep_33_183 |
ESTHER : Horsman_2016_Nat.Prod.Rep_33_183 |
PubMedSearch : Horsman_2016_Nat.Prod.Rep_33_183 |
PubMedID: 25642666 |
Title : Structures of a Nonribosomal Peptide Synthetase Module Bound to MbtH-like Proteins Support a Highly Dynamic Domain Architecture - Miller_2016_J.Biol.Chem_291_22559 |
Author(s) : Miller BR , Drake EJ , Shi C , Aldrich CC , Gulick AM |
Ref : Journal of Biological Chemistry , 291 :22559 , 2016 |
Abstract : Miller_2016_J.Biol.Chem_291_22559 |
ESTHER : Miller_2016_J.Biol.Chem_291_22559 |
PubMedSearch : Miller_2016_J.Biol.Chem_291_22559 |
PubMedID: 27597544 |
Gene_locus related to this paper: ecoli-entf |
Title : Structures of two distinct conformations of holo-non-ribosomal peptide synthetases - Drake_2016_Nature_529_235 |
Author(s) : Drake EJ , Miller BR , Shi C , Tarrasch JT , Sundlov JA , Allen CL , Skiniotis G , Aldrich CC , Gulick AM |
Ref : Nature , 529 :235 , 2016 |
Abstract : Drake_2016_Nature_529_235 |
ESTHER : Drake_2016_Nature_529_235 |
PubMedSearch : Drake_2016_Nature_529_235 |
PubMedID: 26762461 |
Gene_locus related to this paper: aciba-AB3403 , ecoli-entf |
Title : Crystal Structure and Substrate Specificity of Human Thioesterase 2: Insights into the Molecular Basis for the Modulation of Fatty Acid Synthase - Ritchie_2016_J.Biol.Chem_291_3520 |
Author(s) : Ritchie MK , Johnson LC , Clodfelter JE , Pemble CWt , Fulp BE , Furdui CM , Kridel SJ , Lowther WT |
Ref : Journal of Biological Chemistry , 291 :3520 , 2016 |
Abstract : Ritchie_2016_J.Biol.Chem_291_3520 |
ESTHER : Ritchie_2016_J.Biol.Chem_291_3520 |
PubMedSearch : Ritchie_2016_J.Biol.Chem_291_3520 |
PubMedID: 26663084 |
Gene_locus related to this paper: human-OLAH |
Title : Towards a characterization of the structural determinants of specificity in the macrocyclizing thioesterase for deoxyerythronolide B biosynthesis - Argyropoulos_2016_Biochim.Biophys.Acta_1860_486 |
Author(s) : Argyropoulos P , Bergeret F , Pardin C , Reimer JM , Pinto A , Boddy CN , Schmeing TM |
Ref : Biochimica & Biophysica Acta , 1860 :486 , 2016 |
Abstract : Argyropoulos_2016_Biochim.Biophys.Acta_1860_486 |
ESTHER : Argyropoulos_2016_Biochim.Biophys.Acta_1860_486 |
PubMedSearch : Argyropoulos_2016_Biochim.Biophys.Acta_1860_486 |
PubMedID: 26592346 |
Gene_locus related to this paper: sacer-ery3 |
Title : Estimation of Hydrogen-Exchange Protection Factors from MD Simulation Based on Amide Hydrogen Bonding Analysis - Park_2015_J.Chem.Inf.Model_55_1914 |
Author(s) : Park IH , Venable JD , Steckler C , Cellitti SE , Lesley SA , Spraggon G , Brock A |
Ref : J Chem Inf Model , 55 :1914 , 2015 |
Abstract : Park_2015_J.Chem.Inf.Model_55_1914 |
ESTHER : Park_2015_J.Chem.Inf.Model_55_1914 |
PubMedSearch : Park_2015_J.Chem.Inf.Model_55_1914 |
PubMedID: 26241692 |
Gene_locus related to this paper: human-FASN |
Title : Rational reprogramming of fungal polyketide first-ring cyclization - Xu_2013_Proc.Natl.Acad.Sci.U.S.A_110_5398 |
Author(s) : Xu Y , Zhou T , Zhou Z , Su S , Roberts SA , Montfort WR , Zeng J , Chen M , Zhang W , Lin M , Zhan J , Molnar I |
Ref : Proc Natl Acad Sci U S A , 110 :5398 , 2013 |
Abstract : Xu_2013_Proc.Natl.Acad.Sci.U.S.A_110_5398 |
ESTHER : Xu_2013_Proc.Natl.Acad.Sci.U.S.A_110_5398 |
PubMedSearch : Xu_2013_Proc.Natl.Acad.Sci.U.S.A_110_5398 |
PubMedID: 23509261 |
Gene_locus related to this paper: aspte-curs2 , floch-rads2 |
Title : Thioesterase domains of fungal nonreducing polyketide synthases act as decision gates during combinatorial biosynthesis - Xu_2013_J.Am.Chem.Soc_135_10783 |
Author(s) : Xu Y , Zhou T , Zhang S , Xuan LJ , Zhan J , Molnar I |
Ref : Journal of the American Chemical Society , 135 :10783 , 2013 |
Abstract : Xu_2013_J.Am.Chem.Soc_135_10783 |
ESTHER : Xu_2013_J.Am.Chem.Soc_135_10783 |
PubMedSearch : Xu_2013_J.Am.Chem.Soc_135_10783 |
PubMedID: 23822773 |
Gene_locus related to this paper: aspte-curs2 , floch-rads2 |
Title : Structural basis for phosphopantetheinyl carrier domain interactions in the terminal module of nonribosomal peptide synthetases. - Liu_2011_Chem.Biol_18_1482 |
Author(s) : Liu Y , Zheng T , Bruner SD |
Ref : Chemical Biology , 18 :1482 , 2011 |
Abstract : Liu_2011_Chem.Biol_18_1482 |
ESTHER : Liu_2011_Chem.Biol_18_1482 |
PubMedSearch : Liu_2011_Chem.Biol_18_1482 |
PubMedID: 22118682 |
Gene_locus related to this paper: ecoli-entf |
Title : ThYme: a database for thioester-active enzymes - Cantu_2011_Nucleic.Acids.Res_39_D342 |
Author(s) : Cantu DC , Chen Y , Lemons ML , Reilly PJ |
Ref : Nucleic Acids Research , 39 :D342 , 2011 |
Abstract : Cantu_2011_Nucleic.Acids.Res_39_D342 |
ESTHER : Cantu_2011_Nucleic.Acids.Res_39_D342 |
PubMedSearch : Cantu_2011_Nucleic.Acids.Res_39_D342 |
PubMedID: 21045059 |
Title : Crystal structure of FAS thioesterase domain with polyunsaturated fatty acyl adduct and inhibition by dihomo-gamma-linolenic acid - Zhang_2011_Proc.Natl.Acad.Sci.U.S.A_108_15757 |
Author(s) : Zhang W , Chakravarty B , Zheng F , Gu Z , Wu H , Mao J , Wakil SJ , Quiocho FA |
Ref : Proc Natl Acad Sci U S A , 108 :15757 , 2011 |
Abstract : Zhang_2011_Proc.Natl.Acad.Sci.U.S.A_108_15757 |
ESTHER : Zhang_2011_Proc.Natl.Acad.Sci.U.S.A_108_15757 |
PubMedSearch : Zhang_2011_Proc.Natl.Acad.Sci.U.S.A_108_15757 |
PubMedID: 21908709 |
Gene_locus related to this paper: human-FASN |
Title : Structure and function of the RedJ protein, a thioesterase from the prodiginine biosynthetic pathway in Streptomyces coelicolor - Whicher_2011_J.Biol.Chem_286_22558 |
Author(s) : Whicher JR , Florova G , Sydor PK , Singh R , Alhamadsheh M , Challis GL , Reynolds KA , Smith JL |
Ref : Journal of Biological Chemistry , 286 :22558 , 2011 |
Abstract : Whicher_2011_J.Biol.Chem_286_22558 |
ESTHER : Whicher_2011_J.Biol.Chem_286_22558 |
PubMedSearch : Whicher_2011_J.Biol.Chem_286_22558 |
PubMedID: 21543318 |
Gene_locus related to this paper: strco-SC3F7.14 |
Title : Structure and function of an iterative polyketide synthase thioesterase domain catalyzing Claisen cyclization in aflatoxin biosynthesis - Korman_2010_Proc.Natl.Acad.Sci.U.S.A_107_6246 |
Author(s) : Korman TP , Crawford JM , Labonte JW , Newman AG , Wong J , Townsend CA , Tsai SC |
Ref : Proc Natl Acad Sci U S A , 107 :6246 , 2010 |
Abstract : Korman_2010_Proc.Natl.Acad.Sci.U.S.A_107_6246 |
ESTHER : Korman_2010_Proc.Natl.Acad.Sci.U.S.A_107_6246 |
PubMedSearch : Korman_2010_Proc.Natl.Acad.Sci.U.S.A_107_6246 |
PubMedID: 20332208 |
Gene_locus related to this paper: aspor-PKSL1 |
Title : Thioesterases: a new perspective based on their primary and tertiary structures. - Cantu_2010_Protein.Sci_19_1281 |
Author(s) : Cantu DC , Chen Y , Reilly PJ |
Ref : Protein Science , 19 :1281 , 2010 |
Abstract : Cantu_2010_Protein.Sci_19_1281 |
ESTHER : Cantu_2010_Protein.Sci_19_1281 |
PubMedSearch : Cantu_2010_Protein.Sci_19_1281 |
PubMedID: 20506386 |
Title : Biochemical and structural characterization of the tautomycetin thioesterase: analysis of a stereoselective polyketide hydrolase - |
Author(s) : Scaglione JB , Akey DL , Sullivan R , Kittendorf JD , Rath CM , Kim ES , Smith JL , Sherman DH |
Ref : Angew Chem Int Ed Engl , 49 :5726 , 2010 |
PubMedID: 20623733 |
Gene_locus related to this paper: 9acto-C6ZCS0 |
Title : Structure and functional analysis of RifR, the type II thioesterase from the rifamycin biosynthetic pathway - Claxton_2009_J.Biol.Chem_284_5021 |
Author(s) : Claxton HB , Akey DL , Silver MK , Admiraal SJ , Smith JL |
Ref : Journal of Biological Chemistry , 284 :5021 , 2009 |
Abstract : Claxton_2009_J.Biol.Chem_284_5021 |
ESTHER : Claxton_2009_J.Biol.Chem_284_5021 |
PubMedSearch : Claxton_2009_J.Biol.Chem_284_5021 |
PubMedID: 19103602 |
Gene_locus related to this paper: amyme-RIFR |
Title : Structural basis for the selectivity of the external thioesterase of the surfactin synthetase - Koglin_2008_Nature_454_907 |
Author(s) : Koglin A , Lohr F , Bernhard F , Rogov VV , Frueh DP , Strieter ER , Mofid MR , Guntert P , Wagner G , Walsh CT , Marahiel MA , Dotsch V |
Ref : Nature , 454 :907 , 2008 |
Abstract : Koglin_2008_Nature_454_907 |
ESTHER : Koglin_2008_Nature_454_907 |
PubMedSearch : Koglin_2008_Nature_454_907 |
PubMedID: 18704089 |
Gene_locus related to this paper: bacsu-srf4 |
Title : Crystal structure of the termination module of a nonribosomal peptide synthetase - Tanovic_2008_Science_321_659 |
Author(s) : Tanovic A , Samel SA , Essen LO , Marahiel MA |
Ref : Science , 321 :659 , 2008 |
Abstract : Tanovic_2008_Science_321_659 |
ESTHER : Tanovic_2008_Science_321_659 |
PubMedSearch : Tanovic_2008_Science_321_659 |
PubMedID: 18583577 |
Gene_locus related to this paper: bacsu-srfac |
Title : Dynamic thiolation-thioesterase structure of a non-ribosomal peptide synthetase - Frueh_2008_Nature_454_903 |
Author(s) : Frueh DP , Arthanari H , Koglin A , Vosburg DA , Bennett AE , Walsh CT , Wagner G |
Ref : Nature , 454 :903 , 2008 |
Abstract : Frueh_2008_Nature_454_903 |
ESTHER : Frueh_2008_Nature_454_903 |
PubMedSearch : Frueh_2008_Nature_454_903 |
PubMedID: 18704088 |
Gene_locus related to this paper: ecoli-entf |
Title : The crystal structure of a mammalian fatty acid synthase - Maier_2008_Science_321_1315 |
Author(s) : Maier T , Leibundgut M , Ban N |
Ref : Science , 321 :1315 , 2008 |
Abstract : Maier_2008_Science_321_1315 |
ESTHER : Maier_2008_Science_321_1315 |
PubMedSearch : Maier_2008_Science_321_1315 |
PubMedID: 18772430 |
Gene_locus related to this paper: pig-q58g70 |
Title : Deconstruction of iterative multidomain polyketide synthase function - Crawford_2008_Science_320_243 |
Author(s) : Crawford JM , Thomas PM , Scheerer JR , Vagstad AL , Kelleher NL , Townsend CA |
Ref : Science , 320 :243 , 2008 |
Abstract : Crawford_2008_Science_320_243 |
ESTHER : Crawford_2008_Science_320_243 |
PubMedSearch : Crawford_2008_Science_320_243 |
PubMedID: 18403714 |
Gene_locus related to this paper: aspor-PKSL1 , asppa-q6ueg5 |
Title : Crystal structure of the thioesterase domain of human fatty acid synthase inhibited by Orlistat - Pemble_2007_Nat.Struct.Mol.Biol_14_704 |
Author(s) : Pemble CWt , Johnson LC , Kridel SJ , Lowther WT |
Ref : Nat Struct Mol Biol , 14 :704 , 2007 |
Abstract : Pemble_2007_Nat.Struct.Mol.Biol_14_704 |
ESTHER : Pemble_2007_Nat.Struct.Mol.Biol_14_704 |
PubMedSearch : Pemble_2007_Nat.Struct.Mol.Biol_14_704 |
PubMedID: 17618296 |
Gene_locus related to this paper: human-FASN |
Title : Structural and mechanistic insights into polyketide macrolactonization from polyketide-based affinity labels - Giraldes_2006_Nat.Chem.Biol_2_531 |
Author(s) : Giraldes JW , Akey DL , Kittendorf JD , Sherman DH , Smith JL , Fecik RA |
Ref : Nat Chemical Biology , 2 :531 , 2006 |
Abstract : Giraldes_2006_Nat.Chem.Biol_2_531 |
ESTHER : Giraldes_2006_Nat.Chem.Biol_2_531 |
PubMedSearch : Giraldes_2006_Nat.Chem.Biol_2_531 |
PubMedID: 16969373 |
Gene_locus related to this paper: strve-PIKAIV |
Title : Structural basis for macrolactonization by the pikromycin thioesterase - Akey_2006_Nat.Chem.Biol_2_537 |
Author(s) : Akey DL , Kittendorf JD , Giraldes JW , Fecik RA , Sherman DH , Smith JL |
Ref : Nat Chemical Biology , 2 :537 , 2006 |
Abstract : Akey_2006_Nat.Chem.Biol_2_537 |
ESTHER : Akey_2006_Nat.Chem.Biol_2_537 |
PubMedSearch : Akey_2006_Nat.Chem.Biol_2_537 |
PubMedID: 16969372 |
Gene_locus related to this paper: strve-PIKAIV |
Title : The thioesterase domain of the fengycin biosynthesis cluster: a structural base for the macrocyclization of a non-ribosomal lipopeptide - Samel_2006_J.Mol.Biol_359_876 |
Author(s) : Samel SA , Wagner B , Marahiel MA , Essen LO |
Ref : Journal of Molecular Biology , 359 :876 , 2006 |
Abstract : Samel_2006_J.Mol.Biol_359_876 |
ESTHER : Samel_2006_J.Mol.Biol_359_876 |
PubMedSearch : Samel_2006_J.Mol.Biol_359_876 |
PubMedID: 16697411 |
Gene_locus related to this paper: bacsu-FENB |
Title : Human fatty acid synthase: structure and substrate selectivity of the thioesterase domain - Chakravarty_2004_Proc.Natl.Acad.Sci.U.S.A_101_15567 |
Author(s) : Chakravarty B , Gu Z , Chirala SS , Wakil SJ , Quiocho FA |
Ref : Proc Natl Acad Sci U S A , 101 :15567 , 2004 |
Abstract : Chakravarty_2004_Proc.Natl.Acad.Sci.U.S.A_101_15567 |
ESTHER : Chakravarty_2004_Proc.Natl.Acad.Sci.U.S.A_101_15567 |
PubMedSearch : Chakravarty_2004_Proc.Natl.Acad.Sci.U.S.A_101_15567 |
PubMedID: 15507492 |
Gene_locus related to this paper: human-FASN |
Title : Structural basis for the cyclization of the lipopeptide antibiotic surfactin by the thioesterase domain SrfTE. - Bruner_2002_Structure_10_301 |
Author(s) : Bruner SD , Weber T , Kohli RM , Schwarzer D , Marahiel MA , Walsh CT , Stubbs MT |
Ref : Structure , 10 :301 , 2002 |
Abstract : Bruner_2002_Structure_10_301 |
ESTHER : Bruner_2002_Structure_10_301 |
PubMedSearch : Bruner_2002_Structure_10_301 |
PubMedID: 12005429 |
Gene_locus related to this paper: bacsu-srfac |
Title : Insights into channel architecture and substrate specificity from crystal structures of two macrocycle-forming thioesterases of modular polyketide synthases - Tsai_2002_Biochemistry_41_12598 |
Author(s) : Tsai SC , Lu H , Cane DE , Khosla C , Stroud RM |
Ref : Biochemistry , 41 :12598 , 2002 |
Abstract : Tsai_2002_Biochemistry_41_12598 |
ESTHER : Tsai_2002_Biochemistry_41_12598 |
PubMedSearch : Tsai_2002_Biochemistry_41_12598 |
PubMedID: 12379102 |
Gene_locus related to this paper: sacer-ery3 , strve-PIKAIV |
Title : Crystal structure of the macrocycle-forming thioesterase domain of the erythromycin polyketide synthase: versatility from a unique substrate channel - Tsai_2001_Proc.Natl.Acad.Sci.U.S.A_98_14808 |
Author(s) : Tsai SC , Miercke LJ , Krucinski J , Gokhale R , Chen JC , Foster PG , Cane DE , Khosla C , Stroud RM |
Ref : Proc Natl Acad Sci U S A , 98 :14808 , 2001 |
Abstract : Tsai_2001_Proc.Natl.Acad.Sci.U.S.A_98_14808 |
ESTHER : Tsai_2001_Proc.Natl.Acad.Sci.U.S.A_98_14808 |
PubMedSearch : Tsai_2001_Proc.Natl.Acad.Sci.U.S.A_98_14808 |
PubMedID: 11752428 |
Gene_locus related to this paper: sacer-ery3 |
Title : Fatty acid synthesis: a potential selective target for antineoplastic therapy. - |
Author(s) : Kuhajda FP , Jenner K , Wood FD , Hennigar RA , Jacobs LB , Dick JD , Pasternack GR |
Ref : Proceedings of the National Academy of Sciences of the United States of America , 91 :6379 , 1994 |
PubMedID: 8022791 |
Gene_locus related to this paper: human-FASN |
Structures (84)
Genes Proteins in Thioesterase family (629)
Fragments of genes in Thioesterase family (27)
Structures in Thioesterase family (84)Substrates in Thioesterase family (9)
Inhibitors in Thioesterase family (29)