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Family Report for: Thioesterase_acyl-transferase

Thioesterase_acyl-transferase



Relationship
Block X
Comment
This bacterial family of Acyl transferases (ACT or myristoyl-acp-specific thioesterases) catalyses the first step in the bioluminescent fatty acid reductase system, which is required for aldehyde biosynthesis. This enzyme belongs to the LuxD family. Together with acyl-protein synthetase (LuxE) and reductase (LuxC), it belongs to a multienzyme complex. This complex channels activated fatty acids into the aldehyde substrate for the luciferase-catalyzed bacterial bioluminescence reaction. The C-terminal region of LuxD interacts with LuxE to causes a conformational change. LuxD has a calculated M(r) of 34,384 and comprises 305 aa residues. Induction of luminescence only occurs at high cell density. Some bacteria have N-acylhomoserine lactone autoinducers for luminescence. Warning: the serine 77 in GXSXG motif is not the active site serine 114 as determined by X ray structure AASLS in Vibrio harveyi see Lawson_1994_Biochemistry_33_9382. Family TE19 in ThYme database

Database
Sequences
Interpro
|
IPR003157 (Acyl transferase, LuxD)
PIRSF
|
Pdoc
|
PFam
|
PF02273 (Acyl_transf_2)
Prints
|
Prosite
|
no EC number



Peptide in
|Fasta
Nucleotide in
|Fasta
Alignment with Multalin
|Text only/graphic display
Seed alignment with MAFFT
|No colour/coloured with Mview
Alignment with MAFFT
|No colour/coloured with Mview
Dendrogram
|Graphical display, obtained with the dnd file produced by Clustalw

References
2 more
    Title: Thioesterases: a new perspective based on their primary and tertiary structures.
    Cantu DC, Chen Y, Reilly PJ
    Ref: Protein Science, 19:1281, 2010 : PubMed

            

    Title: Structure of a myristoyl-ACP-specific thioesterase from Vibrio harveyi
    Lawson DM, Derewenda U, Serre L, Ferri S, Szittner R, Wei Y, Meighen EA, Derewenda ZS
    Ref: Biochemistry, 33:9382, 1994 : PubMed

            

    Title: Sequence of the luxD gene encoding acyltransferase of the lux operon from Photobacterium leiognathi
    Chao YF, Weng SF, Lin JW
    Ref: Gene, 126:155, 1993 : PubMed

            

Other Papers


Structure scheme for Thioesterase_acyl-transferase

Structures in Thioesterase_acyl-transferase family (1)

Genes Proteins in Thioesterase_acyl-transferase family (17)

No fragments
Substrates of some enzymes in the Thioesterase_acyl-transferase family (1)

No Inhibitor



Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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