Tiancimycin-TnmK-Tripeptidase-HIP
Relationship
Comment
Tnmk1 enzymes responsible for the C-C bond formation linking the anthraquinone moiety and enediyne core together in tiancimycin (TNM) biosynthesis. The anthraquinone-fused enediyne (AFE) are a class of DNA-cleaving bacterial natural products composed of a DNA-intercalating anthraquinone moiety and a 10-membered enediyne warhead. AFE are used to produce AFE-based antibody-drug conjugates. The family contains also members of other gene products included in different biosynthetic gene clusters (BGC) and polyketide synthases (PKS) including UcmK1, and DynA4. TnmK1 shares significant homology with proteases including the serine protease Hip1 (Hydrolase important for pathogenesis) from Mycobacterium tuberculosis now included in this family. All bacterial sequences. Fungi sequences might be due to horizontal transfer.Database
Interpro : No interpro
PIRSF : No PIRSF
Pdoc : No Pdoc
Pfam : No Pfam
Prints : No Print
EC Number : No EC Number
References (6)
| Title : Cofactorless oxygenases guide anthraquinone-fused enediyne biosynthesis - Gui_2023_Nat.Chem.Biol__ |
| Author(s) : Gui C , Kalkreuter E , Liu YC , Li G , Steele AD , Yang D , Chang C , Shen B |
| Ref : Nat Chemical Biology , : , 2023 |
| Abstract : Gui_2023_Nat.Chem.Biol__ |
| ESTHER : Gui_2023_Nat.Chem.Biol__ |
| PubMedSearch : Gui_2023_Nat.Chem.Biol__ |
| PubMedID: 37945897 |
| Gene_locus related to this paper: strsp-TnmK2 |
| Title : Intramolecular C-C Bond Formation Links Anthraquinone and Enediyne Scaffolds in Tiancimycin Biosynthesis - Gui_2022_J.Am.Chem.Soc__ |
| Author(s) : Gui C , Kalkreuter E , Liu YC , Adhikari A , Teijaro CN , Yang D , Chang C , Shen B |
| Ref : Journal of the American Chemical Society , : , 2022 |
| Abstract : Gui_2022_J.Am.Chem.Soc__ |
| ESTHER : Gui_2022_J.Am.Chem.Soc__ |
| PubMedSearch : Gui_2022_J.Am.Chem.Soc__ |
| PubMedID: 36279548 |
| Gene_locus related to this paper: strsp-TnmK1 |
| Title : Structure Determination of Mycobacterium tuberculosis Serine Protease Hip1 (Rv2224c) - Naffin-Olivos_2017_Biochemistry_56_2304 |
| Author(s) : Naffin-Olivos JL , Daab A , White A , Goldfarb NE , Milne AC , Liu D , Baikovitz J , Dunn BM , Rengarajan J , Petsko GA , Ringe D |
| Ref : Biochemistry , 56 :2304 , 2017 |
| Abstract : Naffin-Olivos_2017_Biochemistry_56_2304 |
| ESTHER : Naffin-Olivos_2017_Biochemistry_56_2304 |
| PubMedSearch : Naffin-Olivos_2017_Biochemistry_56_2304 |
| PubMedID: 28346784 |
| Gene_locus related to this paper: myctu-ym24 |
| Title : Mycobacterium tuberculosis Hip1 modulates macrophage responses through proteolysis of GroEL2 - Naffin-Olivos_2014_PLoS.Pathog_10_e1004132 |
| Author(s) : Naffin-Olivos JL , Georgieva M , Goldfarb N , Madan-Lala R , Dong L , Bizzell E , Valinetz E , Brandt GS , Yu S , Shabashvili DE , Ringe D , Dunn BM , Petsko GA , Rengarajan J |
| Ref : PLoS Pathog , 10 :e1004132 , 2014 |
| Abstract : Naffin-Olivos_2014_PLoS.Pathog_10_e1004132 |
| ESTHER : Naffin-Olivos_2014_PLoS.Pathog_10_e1004132 |
| PubMedSearch : Naffin-Olivos_2014_PLoS.Pathog_10_e1004132 |
| PubMedID: 24830429 |
| Gene_locus related to this paper: myctu-ym24 |
| Title : Mycobacterium tuberculosis Hip1 dampens macrophage proinflammatory responses by limiting toll-like receptor 2 activation - Madan-Lala_2011_Infect.Immun_79_4828 |
| Author(s) : Madan-Lala R , Peixoto KV , Re F , Rengarajan J |
| Ref : Infect Immun , 79 :4828 , 2011 |
| Abstract : Madan-Lala_2011_Infect.Immun_79_4828 |
| ESTHER : Madan-Lala_2011_Infect.Immun_79_4828 |
| PubMedSearch : Madan-Lala_2011_Infect.Immun_79_4828 |
| PubMedID: 21947769 |
| Gene_locus related to this paper: myctu-ym24 |
| Title : Cloning and characterization of a gene encoding a secreted tripeptidyl aminopeptidase from Streptomyces lividans 66 - Butler_1995_Appl.Environ.Microbiol_61_3145 |
| Author(s) : Butler MJ , Binnie C , DiZonno MA , Krygsman P , Soltes GA , Soostmeyer G , Walczyk E , Malek LT |
| Ref : Applied Environmental Microbiology , 61 :3145 , 1995 |
| Abstract : Butler_1995_Appl.Environ.Microbiol_61_3145 |
| ESTHER : Butler_1995_Appl.Environ.Microbiol_61_3145 |
| PubMedSearch : Butler_1995_Appl.Environ.Microbiol_61_3145 |
| PubMedID: 7487044 |
| Gene_locus related to this paper: strco-TAP |
Structures (11)
Genes Proteins in Tiancimycin-TnmK-Tripeptidase-HIP family (317)
No fragment of genes
Structures in Tiancimycin-TnmK-Tripeptidase-HIP family (11)Substrates in Tiancimycin-TnmK-Tripeptidase-HIP family (5)
Inhibitors in Tiancimycin-TnmK-Tripeptidase-HIP family (2)