Gene_Locus Report

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Gene_locus Report for: 9arch-KY203036

Uncultured archaeon EH49 clone 00173_9_12ROV11 esterase/lipase

Comment
EH49 promiscuous activity 23/96 substrates Martinez-Martinez et al. 2018


Relationship
Family|AlphaBeta_hydrolase
Block| X
Position in NCBI Life Tree|uncultured archaeon
(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)
> cellular organisms: N E > Archaea: N E > environmental samples: N E > uncultured archaeon: N E


Molecular evidence
Database
No mutation
No structure
No kinetic





No Substrate
No inhibitor
2 Genbank : KY203036, ATZ76877
1 UniProt : A0A2H4ULE0
1 UniProt : A0A2H4ULE0
1 Interpro : A0A2H4ULE0
1 Prodom : A0A2H4ULE0
1 Pfam : A0A2H4ULE0
1 PIRSF : A0A2H4ULE0
1 SUPERFAM : A0A2H4ULE0
Sequence
Graphical view for this peptide sequence: 9arch-KY203036
Colored MSA for AlphaBeta_hydrolase (raw)
MFLDINISGNFARIYVENTVLLCHGLPAEPGSVVEKGYDKLARYFARYFT
PVIFDFSGCGLSRKEFSLRRWVEDLINIAGSFSHVDIVAFSMGGVPAVYT
AANLRNVRSVTLVATPCCFDVLSLKILQEVHANAKTRGTLRVGDFSSFVM
GLKEDMMEFEPLRWIEKVKNVLLVHGTKDDVVPLESSEKLFRFAKSPKKL
LKVIGGGHKLRQEKAVVDKIIEWITGEKKKESVEIIP
Legend This sequence has been compared to family alignement (MSA)
red => minority aminoacid
blue => majority aminoacid
color intensity => conservation rate
title => sequence position(MSA position)aminoacid rate
Catalytic site
Catalytic site in the MSA

MFLDINISGNFARIYVENTVLLCHGLPAEPGSVVEKGYDKLARYFARYFT
PVIFDFSGCGLSRKEFSLRRWVEDLINIAGSFSHVDIVAFSMGGVPAVYT
AANLRNVRSVTLVATPCCFDVLSLKILQEVHANAKTRGTLRVGDFSSFVM
GLKEDMMEFEPLRWIEKVKNVLLVHGTKDDVVPLESSEKLFRFAKSPKKL
LKVIGGGHKLRQEKAVVDKIIEWITGEKKKESVEIIP


Reference
    Title: Determinants and prediction of esterase substrate promiscuity patterns
    Martinez-Martinez M, Coscolin C, Santiago G, Chow J, Stogios PJ, Bargiela R, Gertler C, Navarro-Fernandez J, Bollinger A and Ferrer M <32 more author(s)>
    Ref: ACS Chemical Biology, 13:225, 2018 : PubMed

            


Other Papers


Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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