Gene_Locus Report

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Gene_locus Report for: 9bact-MGS-M2

uncultured bacterium EH107 alpha/beta hydrolase enzyme MGS-M2

Comment
EH107 promiscuous activity 9/96 substrates Martinez-Martinez et al. 2018


Relationship
Family|6_AlphaBeta_hydrolase
Block| X
Position in NCBI Life Tree|uncultured bacterium
(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)
> cellular organisms: N E > Bacteria: N E > environmental samples: N E > uncultured bacterium: N E
Warning: This entry is a compilation of different species or line or strain with more than 90% amino acide identity. You can retrieve all strain data


Molecular evidence
Database
No mutation
1 structure:
4Q3L: Crystal structure of MGS-M2, an alpha/beta hydrolase enzyme from a Medee basin deep-sea metagenome library
No kinetic





No Substrate
No inhibitor
1 UniProt : A0A0B5KBT7
1 Structure : 4Q3L
1 UniProt : A0A0B5KBT7
1 Interpro : A0A0B5KBT7
1 Prodom : A0A0B5KBT7
1 Pfam : A0A0B5KBT7
1 PIRSF : A0A0B5KBT7
1 SUPERFAM : A0A0B5KBT7
Sequence
Graphical view for this peptide sequence: 9bact-MGS-M2
Colored MSA for 6_AlphaBeta_hydrolase (raw)
GRENLYFQGVSIFTYQEKDIYYEIDGTLDINSDVIVILNGIMMSTKSWDA
FVENFSKNHVLLRYDMFDQGQSSKIEESYTQTIQVELLKNLLEHLGIAQA
NIVGISYGASIALQFAAKYPTMIKRMVVANVVAKTSPWLKDIGDGWNEVA
KTGNGLAYYHITIPYIYSPQFYTLHNDWMEKRKELLVPLFSTRTFLDRMI
RLTKSAETHDVIKDLPNIKTPTLIISSEEDYLTPPFEQKYLQEHLQNAEL
VSIPNCGHASMYEVPKTFTALVLGFFGQTKLDYQI
Legend This sequence has been compared to family alignement (MSA)
red => minority aminoacid
blue => majority aminoacid
color intensity => conservation rate
title => sequence position(MSA position)aminoacid rate
Catalytic site
Catalytic site in the MSA

GRENLYFQGVSIFTYQEKDIYYEIDGTLDINSDVIVILNGIMMSTKSWDA
FVENFSKNHVLLRYDMFDQGQSSKIEESYTQTIQVELLKNLLEHLGIAQA
NIVGISYGASIALQFAAKYPTMIKRMVVANVVAKTSPWLKDIGDGWNEVA
KTGNGLAYYHITIPYIYSPQFYTLHNDWMEKRKELLVPLFSTRTFLDRMI
RLTKSAETHDVIKDLPNIKTPTLIISSEEDYLTPPFEQKYLQEHLQNAEL
VSIPNCGHASMYEVPKTFTALVLGFFGQTKLDYQI


References
    Title: Determinants and prediction of esterase substrate promiscuity patterns
    Martinez-Martinez M, Coscolin C, Santiago G, Chow J, Stogios PJ, Bargiela R, Gertler C, Navarro-Fernandez J, Bollinger A and Ferrer M <32 more author(s)>
    Ref: ACS Chemical Biology, 13:225, 2018 : PubMed

            

    Title: Pressure adaptation is linked to thermal adaptation in salt-saturated marine habitats
    Alcaide M, Stogios PJ, Lafraya A, Tchigvintsev A, Flick R, Bargiela R, Chernikova TN, Reva ON, Hai T and Ferrer M <11 more author(s)>
    Ref: Environ Microbiol, 17:332, 2015 : PubMed

            


Other Papers


Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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