Gene_Locus Report

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Gene_locus Report for: 9bact-t1w006

uncultured bacterium EH72 Esterase

Comment
EH72 promiscuous activity 18/96 substrates Martinez-Martinez et al. 2018


Relationship
Family|6_AlphaBeta_hydrolase
Block| X
Position in NCBI Life Tree|uncultured organism
(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)
> unclassified sequences: N E > environmental samples: N E > uncultured organism: N E
Warning: This entry is a compilation of different species or line or strain with more than 90% amino acide identity. You can retrieve all strain data


Molecular evidence
Database
No mutation
No structure
No kinetic





No Substrate
No inhibitor
2 Genbank : KC986401, AGT96415
1 UniProt : T1W006
1 UniProt : T1W006
1 Interpro : T1W006
1 Prodom : T1W006
1 Pfam : T1W006
1 PIRSF : T1W006
1 SUPERFAM : T1W006
Sequence
Graphical view for this peptide sequence: 9bact-t1w006
Colored MSA for 6_AlphaBeta_hydrolase (raw)
MELNSMQFLLGLIGLLLLIVTSLRRWLLRRESPQKQAVDFHGELYQVGSA
VIARSRADAPAGSVIVMHGFVENFLYFTEHYADPDIQLIMLTSADYHLPV
NQPRFTKADWIKIPGQRPGTIAYDAAVLNQALEHLATGTQIRVHGHSRGG
AVTLEAARQRPDLFARVEVILEAPVLPQGKPYKAVSPLARWFAPFYLFAW
QQQPISPANAKVFGPLDNPRKRELIMALPFNPRYGRTFVNNIKDLADWMD
STGTDIYQHVKFGAILVPSHDLILNASAMLQSAQQAESLQIIEVEGCSHL
ITADRPDSIPPLPG
Legend This sequence has been compared to family alignement (MSA)
red => minority aminoacid
blue => majority aminoacid
color intensity => conservation rate
title => sequence position(MSA position)aminoacid rate
Catalytic site
Catalytic site in the MSA

MELNSMQFLLGLIGLLLLIVTSLRRWLLRRESPQKQAVDFHGELYQVGSA
VIARSRADAPAGSVIVMHGFVENFLYFTEHYADPDIQLIMLTSADYHLPV
NQPRFTKADWIKIPGQRPGTIAYDAAVLNQALEHLATGTQIRVHGHSRGG
AVTLEAARQRPDLFARVEVILEAPVLPQGKPYKAVSPLARWFAPFYLFAW
QQQPISPANAKVFGPLDNPRKRELIMALPFNPRYGRTFVNNIKDLADWMD
STGTDIYQHVKFGAILVPSHDLILNASAMLQSAQQAESLQIIEVEGCSHL
ITADRPDSIPPLPG


Reference
    Title: Determinants and prediction of esterase substrate promiscuity patterns
    Martinez-Martinez M, Coscolin C, Santiago G, Chow J, Stogios PJ, Bargiela R, Gertler C, Navarro-Fernandez J, Bollinger A and Ferrer M <32 more author(s)>
    Ref: ACS Chemical Biology, 13:225, 2018 : PubMed

            


Other Papers


Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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