(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.) > cellular organisms: NE > Bacteria: NE > Terrabacteria group: NE > Actinobacteria [phylum]: NE > Actinobacteria [class]: NE > Bifidobacteriales: NE > Bifidobacteriaceae: NE > Bifidobacterium: NE > Bifidobacterium dentium: NE
Warning: This entry is a compilation of different species or line or strain with more than 90% amino acide identity. You can retrieve all strain data
(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.) Bifidobacterium dentium ATCC 27678: N, E.
Bifidobacterium dentium Bd1: N, E.
Bifidobacterium dentium ATCC 27679: N, E.
Bifidobacterium dentium JCVIHMP022: N, E.
LegendThis sequence has been compared to family alignement (MSA) red => minority aminoacid blue => majority aminoacid color intensity => conservation rate title => sequence position(MSA position)aminoacid rate Catalytic site Catalytic site in the MSA MNDAIDVFPRLKARTVRFTCGAPRSARTIGDGSRALFLRSDGSEDTVTSL WMSVIDTTGTGDDREVLLADPRELLADADAENVPAEERARRERAREGGSG IVSYSVDQAGRRVVFTINGQLFLTEIREDGTGIRTRQLAFEDLTLTTGGY GPVLNPRISPDGRHVMYTTGEHLNLIDIADWPAPGQAARESITTVYGVCD GNGDDQAPHTVKIGLAEFVAGEEMDRYDGFWWSPDSRYVLFETFDASPEP IWHICDPANPTMGAAARRYPQALTSNADVHLTLLELGFDADGCCYGEVSH AVEWDRERYEYLASVNWAEGHDPIIEVQDRLQRNDQVLTVRVGDPIMPVI APEAEFTDENGDEVETFSFAIPEYAPGEEPGTTRVLEERHNDCWLDLVHG TPAYTPDGRLVCAVNDMEADTNRLSVDGCAFTPIGLQVREVLDVTDDDVL CVVQRTPELLPESDLPYLWQANAADHDARSFDVVSIRFDGSWEPLTHTPG QWTMSRAGNGCVMTGRGMDDARVQMQHCMNVVTVGEDGVETLSMVVAPIE NHAAEPGFVPNARFVRLGERSLYTAIVLPSEGSGYAHADRLPVLMKPYGG PGFQQVVESQSFYWDAQWWADQGYIVVIADGRGTTGRGPKWDRAIYESMK AVTLEDQVDAVHALPGILSELRAEQADSETAVTIPEPDLERVAIIGWSYG GFLSALAVLEAPDVFAAACAGAPPTDWTLYDTHYTERYLGLDPVVYERNG IIADAPNLKRPLMLIHGFADDNVTIAHSLRLSQALMAAGRKHTFLPLTGI THMTNDETVAENLLILQRDFLADALRKV
Bifidobacteria, one of the relatively dominant components of the human intestinal microbiota, are considered one of the key groups of beneficial intestinal bacteria (probiotic bacteria). However, in addition to health-promoting taxa, the genus Bifidobacterium also includes Bifidobacterium dentium, an opportunistic cariogenic pathogen. The genetic basis for the ability of B. dentium to survive in the oral cavity and contribute to caries development is not understood. The genome of B. dentium Bd1, a strain isolated from dental caries, was sequenced to completion to uncover a single circular 2,636,368 base pair chromosome with 2,143 predicted open reading frames. Annotation of the genome sequence revealed multiple ways in which B. dentium has adapted to the oral environment through specialized nutrient acquisition, defences against antimicrobials, and gene products that increase fitness and competitiveness within the oral niche. B. dentium Bd1 was shown to metabolize a wide variety of carbohydrates, consistent with genome-based predictions, while colonization and persistence factors implicated in tissue adhesion, acid tolerance, and the metabolism of human saliva-derived compounds were also identified. Global transcriptome analysis demonstrated that many of the genes encoding these predicted traits are highly expressed under relevant physiological conditions. This is the first report to identify, through various genomic approaches, specific genetic adaptations of a Bifidobacterium taxon, Bifidobacterium dentium Bd1, to a lifestyle as a cariogenic microorganism in the oral cavity. In silico analysis and comparative genomic hybridization experiments clearly reveal a high level of genome conservation among various B. dentium strains. The data indicate that the genome of this opportunistic cariogen has evolved through a very limited number of horizontal gene acquisition events, highlighting the narrow boundaries that separate commensals from opportunistic pathogens.
