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Gene_locus Report for: 9gamm-s5t532

Cycloclasticus zancles 78-ME, EH34 Dual esterases-meta-cleavage product (MCP) hydrolases from the a/b hydrolase family

Comment
EH34 promiscuous activity 29/96 substrates Martinez-Martinez et al. 2018


Relationship
Family|LYsophospholipase_carboxylesterase
Block| X
Position in NCBI Life Tree|Cycloclasticus zancles 78-ME
(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)
> cellular organisms: N E > Bacteria: N E > Proteobacteria: N E > Gammaproteobacteria: N E > Thiotrichales: N E > Piscirickettsiaceae: N E > Cycloclasticus: N E > Cycloclasticus zancles: N E > Cycloclasticus zancles 78-ME: N E
Warning: This entry is a compilation of different species or line or strain with more than 90% amino acide identity. You can retrieve all strain data


Molecular evidence
Database
No mutation
No structure
No kinetic





No Substrate
No inhibitor
2 Genbank : AGS38694, WP_020931947
1 UniProt : S5T532
1 UniProt : S5T532
1 Interpro : S5T532
1 Pfam : S5T532
1 PIRSF : S5T532
1 SUPERFAM : S5T532
Sequence
Graphical view for this peptide sequence: 9gamm-s5t532
Colored MSA for LYsophospholipase_carboxylesterase (raw)
MLATRLPAIISNPNTPIRCSVIWLHGLGANGNDFAPIVSELGIQDELGIR
FVFPHAPSIAVTINGGAVMPAWYDITEMDLMERADNAGIVSSSKTITDMI
NDEIATGIEPSKIVIAGFSQGGVIAFDAGLRFPETLAGIMALSTYIPMQD
TLPTAEQSGHAKIPIFYGHGDFDPVIPIEQADSSRRFLEASGYCVDWHAY
PMEHSVCPQEIHHIKDWLTTVLS
Legend This sequence has been compared to family alignement (MSA)
red => minority aminoacid
blue => majority aminoacid
color intensity => conservation rate
title => sequence position(MSA position)aminoacid rate
Catalytic site
Catalytic site in the MSA

MLATRLPAIISNPNTPIRCSVIWLHGLGANGNDFAPIVSELGIQDELGIR
FVFPHAPSIAVTINGGAVMPAWYDITEMDLMERADNAGIVSSSKTITDMI
NDEIATGIEPSKIVIAGFSQGGVIAFDAGLRFPETLAGIMALSTYIPMQD
TLPTAEQSGHAKIPIFYGHGDFDPVIPIEQADSSRRFLEASGYCVDWHAY
PMEHSVCPQEIHHIKDWLTTVLS


Reference
    Title: Determinants and prediction of esterase substrate promiscuity patterns
    Martinez-Martinez M, Coscolin C, Santiago G, Chow J, Stogios PJ, Bargiela R, Gertler C, Navarro-Fernandez J, Bollinger A and Ferrer M <32 more author(s)>
    Ref: ACS Chemical Biology, 13:225, 2018 : PubMed

            


Other Papers


Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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