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Gene_locus Report for: 9zzzz-t1b379

mine drainage metagenome EH59 Phospholipase/carboxylesterase EstA7

Comment
EH59 promiscuous activity 21/96 substrates Martinez-Martinez et al. 2018


Relationship
Family|LYsophospholipase_carboxylesterase
Block| X
Position in NCBI Life Tree|mine drainage metagenome
(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)
> unclassified sequences: N E > metagenomes: N E > ecological metagenomes: N E > mine drainage metagenome: N E


Molecular evidence
Database
No mutation
No structure
No kinetic





No Substrate
No inhibitor
1 Genbank : EQD63018
1 UniProt : T1B379
1 UniProt : T1B379
1 Interpro : T1B379
1 Prodom : T1B379
1 Pfam : T1B379
1 PIRSF : T1B379
1 SUPERFAM : T1B379
Sequence
Graphical view for this peptide sequence: 9zzzz-t1b379
Colored MSA for LYsophospholipase_carboxylesterase (raw)
MDTQQHIELLPAVEIASGPAPRHSILWLHGLGADGNDFAPIVPELTHGLP
PLRFVFPHAPQRAVTLNGGLRMRAWYDIRSFDLGSHADEGGLRESMAQVQ
ALIAREQRAHGIAADKVFLAGFSQGGAVALCTALRHAQPLAGVIALSTYL
PLTDQLAGERSATNARIPVFMGHGSLDPVVPQMLGAAARDVLTALGHRVD
WHSYPMAHAVLPQEIADLRAWLARQMGD
Legend This sequence has been compared to family alignement (MSA)
red => minority aminoacid
blue => majority aminoacid
color intensity => conservation rate
title => sequence position(MSA position)aminoacid rate
Catalytic site
Catalytic site in the MSA

MDTQQHIELLPAVEIASGPAPRHSILWLHGLGADGNDFAPIVPELTHGLP
PLRFVFPHAPQRAVTLNGGLRMRAWYDIRSFDLGSHADEGGLRESMAQVQ
ALIAREQRAHGIAADKVFLAGFSQGGAVALCTALRHAQPLAGVIALSTYL
PLTDQLAGERSATNARIPVFMGHGSLDPVVPQMLGAAARDVLTALGHRVD
WHSYPMAHAVLPQEIADLRAWLARQMGD


References
    Title: Metagenomic Mining for Esterases in the Microbial Community of Los Rueldos Acid Mine Drainage Formation
    Vidal P, Martinez-Martinez M, Fernandez-Lopez L, Roda S, Mendez-Garcia C, Golyshina OV, Guallar V, Pelaez AI, Ferrer M
    Ref: Front Microbiol, 13:868839, 2022 : PubMed

            

    Title: Determinants and prediction of esterase substrate promiscuity patterns
    Martinez-Martinez M, Coscolin C, Santiago G, Chow J, Stogios PJ, Bargiela R, Gertler C, Navarro-Fernandez J, Bollinger A and Ferrer M <32 more author(s)>
    Ref: ACS Chemical Biology, 13:225, 2018 : PubMed

            


Other Papers


Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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