(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.) > cellular organisms: NE > Bacteria: NE > Proteobacteria: NE > Gammaproteobacteria: NE > Pasteurellales: NE > Pasteurellaceae: NE > Actinobacillus: NE > Actinobacillus pleuropneumoniae: NE
Warning: This entry is a compilation of different species or line or strain with more than 90% amino acid identity. You can retrieve all strain data
(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.) Actinobacillus pleuropneumoniae serovar 5b str. L20: N, E.
Actinobacillus pleuropneumoniae serovar 11 str. 56153: N, E.
Actinobacillus pleuropneumoniae serovar 7 str. AP76: N, E.
Actinobacillus pleuropneumoniae serovar 2 str. S1536: N, E.
Actinobacillus pleuropneumoniae serovar 9 str. CVJ13261: N, E.
Actinobacillus pleuropneumoniae serovar 2 str. 4226: N, E.
Actinobacillus pleuropneumoniae serovar 4 str. M62: N, E.
Actinobacillus pleuropneumoniae serovar 13 str. N273: N, E.
Actinobacillus pleuropneumoniae serovar 10 str. D13039: N, E.
Actinobacillus pleuropneumoniae serovar 12 str. 1096: N, E.
Actinobacillus pleuropneumoniae serovar 1 str. 4074: N, E.
Actinobacillus pleuropneumoniae serovar 3 str. JL03: N, E.
Actinobacillus pleuropneumoniae serovar 6 str. Femo: N, E.
LegendThis sequence has been compared to family alignement (MSA) red => minority aminoacid blue => majority aminoacid color intensity => conservation rate title => sequence position(MSA position)aminoacid rate Catalytic site Catalytic site in the MSA MAHSITLFSEKPLSLILGGMLSPIDVAYQTYGTLNADKSNVVLLCHALTG DAEPYKNAPEQGWWQDFIGSGLAFDTARYFFICSNVLGGCKGTTGPSSIN TKTGKPYGSQFPIITVQDIVEVQKALLDTLGISHLHAVVGGSFGGMQATQ WGISYPDFVSNIINLCSSLTLSAEAIGFNHVMRQAIINDPHFNHGDYYDG LPPDNGLKIARMLGMLTYRTDVQLARAFGREMKQQTEIWGDYFQVESYLS YQGVKFLDRFDANSYLRLLRALDLYDPALGYEHEIDALKRIKANYTLVAI TSDQLFKQIDVLKSKQRLEAAGVQVDYHEFHSNFGHDAFLVDYDFFEPMI RKGLQTET
References
Title: Comparative genomic characterization of Actinobacillus pleuropneumoniae Xu Z, Chen X, Li L, Li T, Wang S, Chen H, Zhou R Ref: Journal of Bacteriology, 192:5625, 2010 : PubMed
The Gram-negative bacterium Actinobacillus pleuropneumoniae is the etiologic agent of porcine contagious pleuropneumoniae, a lethal respiratory infectious disease causing great economic losses in the swine industry worldwide. In order to better interpret the genetic background of serotypic diversity, nine genomes of A. pleuropneumoniae reference strains of serovars 1, 2, 4, 6, 9, 10, 11, 12, and 13 were sequenced by using rapid high-throughput approach. Based on 12 genomes of corresponding serovar reference strains including three publicly available complete genomes (serovars 3, 5b, and 7) of this bacterium, we performed a comprehensive analysis of comparative genomics and first reported a global genomic characterization for this pathogen. Clustering of 26,012 predicted protein-coding genes showed that the pan genome of A. pleuropneumoniae consists of 3,303 gene clusters, which contain 1,709 core genome genes, 822 distributed genes, and 772 strain-specific genes. The genome components involved in the biogenesis of capsular polysaccharide and lipopolysaccharide O antigen relative to serovar diversity were compared, and their genetic diversity was depicted. Our findings shed more light on genomic features associated with serovar diversity of A. pleuropneumoniae and provide broader insight into both pathogenesis research and clinical/epidemiological application against the severe disease caused by this swine pathogen.
Actinobacillus pleuropneumoniae is a bacterial pathogen that causes highly contagious respiratory infection in pigs and has a serious impact on the production economy and animal welfare. As clear differences in virulence between serotypes have been observed, the genetic basis should be investigated at the genomic level. Here, we present the draft genome sequences of the A. pleuropneumoniae serotypes 2 (strain 4226) and 6 (strain Femo).
There are 16 capsule-based serotypes of Actinobacillus pleuropneumoniae, all of which are capable of causing disease in pigs. Here we report the finished and annotated genome sequence of the reference serotype 5b strain L20. This strain has a rough appearance and readily forms biofilms, as is typical for most field isolates.
