Gene_Locus Report

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Gene_locus Report for: alcbs-q0vqa3

Alcanivorax borkumensis (strain ATCC 700651 / DSM 11573 / NCIMB 13689 / SK2) EH128 Carboxylic ester hydrolase

Comment
EH128 promiscuous activity 4/96 substrates Martinez-Martinez et al. 2018


Relationship
Family|ABHD6-Lip
Block| X
Position in NCBI Life Tree|Alcanivorax borkumensis SK2
(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)
> cellular organisms: N E > Bacteria: N E > Proteobacteria: N E > Gammaproteobacteria: N E > Oceanospirillales: N E > Alcanivoracaceae: N E > Alcanivorax: N E > Alcanivorax borkumensis: N E > Alcanivorax borkumensis SK2: N E


Molecular evidence
Database
No mutation
No structure
No kinetic





No Substrate
No inhibitor
3 Genbank : AM286690, CAL16645, WP_011588480
1 UniProt : Q0VQA3
1 UniProt : Q0VQA3
1 Interpro : Q0VQA3
1 Prodom : Q0VQA3
1 Pfam : Q0VQA3
1 PIRSF : Q0VQA3
1 SUPERFAM : Q0VQA3
Sequence
Graphical view for this peptide sequence: alcbs-q0vqa3
Colored MSA for ABHD6-Lip (raw)
MQLKHLFLFIVCSFFLSGCEDITNWAYEKGLAMEKNRAGLKDQILTTADG
ITWHILTSETSAEPIAEKEAVLLIHGFSADSSNWVRFANELEGDFFFIVP
DLPGHGETTRNLDLTYTMSAQATRLLTLMDALQIQHFHVAGNSMGGAISL
ALAQQAPQRVLSIGLIDSAGLTRQTEGFKTILADSNSNPLIPHTAEQFQA
TLQWAMEEPPYLPSFVVDIMGKKKAANAAVAEKVWRDLLEDPGMMLEDKN
VLPSIQIPTLVLWGREDRLLGVDNVGAFLEELPQSRAIVLDGIGHVPMAE
APGKSADAFRAFWREVRP
Legend This sequence has been compared to family alignement (MSA)
red => minority aminoacid
blue => majority aminoacid
color intensity => conservation rate
title => sequence position(MSA position)aminoacid rate
Catalytic site
Catalytic site in the MSA

MQLKHLFLFIVCSFFLSGCEDITNWAYEKGLAMEKNRAGLKDQILTTADG
ITWHILTSETSAEPIAEKEAVLLIHGFSADSSNWVRFANELEGDFFFIVP
DLPGHGETTRNLDLTYTMSAQATRLLTLMDALQIQHFHVAGNSMGGAISL
ALAQQAPQRVLSIGLIDSAGLTRQTEGFKTILADSNSNPLIPHTAEQFQA
TLQWAMEEPPYLPSFVVDIMGKKKAANAAVAEKVWRDLLEDPGMMLEDKN
VLPSIQIPTLVLWGREDRLLGVDNVGAFLEELPQSRAIVLDGIGHVPMAE
APGKSADAFRAFWREVRP


Reference
    Title: Determinants and prediction of esterase substrate promiscuity patterns
    Martinez-Martinez M, Coscolin C, Santiago G, Chow J, Stogios PJ, Bargiela R, Gertler C, Navarro-Fernandez J, Bollinger A and Ferrer M <32 more author(s)>
    Ref: ACS Chemical Biology, 13:225, 2018 : PubMed

            


Other Papers


Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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