Gene_locus Report for: anapl-BCHE

(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)
> cellular organisms: N E > Eukaryota: N E > Opisthokonta: N E > Metazoa: N E > Eumetazoa: N E > Bilateria: N E > Deuterostomia: N E > Chordata: N E > Craniata: N E > Vertebrata: N E > Gnathostomata: N E > Teleostomi: N E > Euteleostomi: N E > Sarcopterygii: N E > Dipnotetrapodomorpha: N E > Tetrapoda: N E > Amniota: N E > Sauropsida: N E > Sauria: N E > Archelosauria: N E > Archosauria: N E > Dinosauria: N E > Saurischia: N E > Theropoda: N E > Coelurosauria: N E > Aves: N E > Neognathae: N E > Galloanserae: N E > Anseriformes: N E > Anatidae: N E > Anas: N E > Anas platyrhynchos: N E

Title: Genome-wide association studies reveal genetic loci associated with plasma cholinesterase activity in ducks
Xu Y, Liu H, Jiang Y, Fan W, Hu J, Zhang Y, Guo Z, Xie M, Huang W and Hou S <2 more author(s)> Xu Y, Liu H, Jiang Y, Fan W, Hu J, Zhang Y, Guo Z, Xie M, Huang W, Liu X, Zhou Z, Hou S (- 2)
Ref: Anim Genet, 50:287, 2019 : PubMed
Abstract


ESTHER: Xu_2019_Anim.Genet_50_287
PubMedSearch: Xu 2019 Anim.Genet 50 287
PubMedID: 30994195
Gene_locus related to this paper: anapl-BCHE

Abstract

Plasma cholinesterase (PCHE) activity is an important auxiliary test in human clinical medicine. It can distinguish liver diseases from non-liver diseases and help detect organophosphorus poisoning. Animal experiments have confirmed that PCHE activity is associated with obesity and hypertension and changes with physiological changes in an animal's body. The objective of this study was to locate the genetic loci responsible for PCHE activity variation in ducks. PCHE activity of Pekin duck x mallard F2 ducks at 3 and 8 weeks of age were analyzed, and genome-wide association studies were conducted. A region of about 1.5 Mb (21.8-23.3 Mb) on duck chromosome 9 was found to be associated with PCHE activity at both 3 and 8 weeks of age. The top SNP, g.22643979C>T in the butyrylcholinesterase (BCHE) gene, was most highly associated with PCHE activity at 3 weeks (-logP = 21.45) and 8 weeks (-logP = 27.60) of age. For the top SNP, the strong associations of CC and CT genotypes with low PCHE activity and the TT genotype with high PCHE activity indicates the dominant inheritance of low PCHE activity. Problems with block inheritance or linkage exist in this region. This study supports that BCHE is a functional gene for determining PCHE levels in ducks and that the genetic variations around this gene can cause phenotypic variations of PCHE activity.



        

Title: The duck genome and transcriptome provide insight into an avian influenza virus reservoir species
Huang Y, Li Y, Burt DW, Chen H, Zhang Y, Qian W, Kim H, Gan S, Zhao Y and Li N <40 more author(s)> Huang Y, Li Y, Burt DW, Chen H, Zhang Y, Qian W, Kim H, Gan S, Zhao Y, Li J, Yi K, Feng H, Zhu P, Li B, Liu Q, Fairley S, Magor KE, Du Z, Hu X, Goodman L, Tafer H, Vignal A, Lee T, Kim KW, Sheng Z, An Y, Searle S, Herrero J, Groenen MA, Crooijmans RP, Faraut T, Cai Q, Webster RG, Aldridge JR, Warren WC, Bartschat S, Kehr S, Marz M, Stadler PF, Smith J, Kraus RH, Ren L, Fei J, Morisson M, Kaiser P, Griffin DK, Rao M, Pitel F, Wang J, Li N (- 40)
Ref: Nat Genet, 45:776, 2013 : PubMed
Abstract


ESTHER: Huang_2013_Nat.Genet_45_776
PubMedSearch: Huang 2013 Nat.Genet 45 776
PubMedID: 23749191
Gene_locus related to this paper: anapl-BCHE, anapl-r0lw36, anapl-r0m5n4, anapl-thioe, anapl-u3iqr9, anapl-r0l4n7, anapl-u3j4v8, anapl-u3icy5, anapl-u3ivv9, anapl-u3j4g1, anapl-u3j4i2, anapl-u3j4v5, anapl-r0kv25, anapl-u3ild2, anapl-u3imh5, anapl-b6dzk9, anapl-u3imp7, anapl-u3i5h5, anapl-u3id17, anapl-r0m1y3, anapl-r0lhc4, anapl-r0ktn0, anapl-r0l8l1, anapl-r0lin6, anapl-r0jhf3

Abstract

The duck (Anas platyrhynchos) is one of the principal natural hosts of influenza A viruses. We present the duck genome sequence and perform deep transcriptome analyses to investigate immune-related genes. Our data indicate that the duck possesses a contractive immune gene repertoire, as in chicken and zebra finch, and this repertoire has been shaped through lineage-specific duplications. We identify genes that are responsive to influenza A viruses using the lung transcriptomes of control ducks and ones that were infected with either a highly pathogenic (A/duck/Hubei/49/05) or a weakly pathogenic (A/goose/Hubei/65/05) H5N1 virus. Further, we show how the duck's defense mechanisms against influenza infection have been optimized through the diversification of its beta-defensin and butyrophilin-like repertoires. These analyses, in combination with the genomic and transcriptomic data, provide a resource for characterizing the interaction between host and influenza viruses.