Gene_locus Report for: anapl-r0l4n7

(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)
> cellular organisms: N E > Eukaryota: N E > Opisthokonta: N E > Metazoa: N E > Eumetazoa: N E > Bilateria: N E > Deuterostomia: N E > Chordata: N E > Craniata: N E > Vertebrata: N E > Gnathostomata: N E > Teleostomi: N E > Euteleostomi: N E > Sarcopterygii: N E > Dipnotetrapodomorpha: N E > Tetrapoda: N E > Amniota: N E > Sauropsida: N E > Sauria: N E > Archelosauria: N E > Archosauria: N E > Dinosauria: N E > Saurischia: N E > Theropoda: N E > Coelurosauria: N E > Aves: N E > Neognathae: N E > Galloanserae: N E > Anseriformes: N E > Anatidae: N E > Anas: N E > Anas platyrhynchos: N E

Title: The duck genome and transcriptome provide insight into an avian influenza virus reservoir species
Huang Y, Li Y, Burt DW, Chen H, Zhang Y, Qian W, Kim H, Gan S, Zhao Y and Li N <40 more author(s)> Huang Y, Li Y, Burt DW, Chen H, Zhang Y, Qian W, Kim H, Gan S, Zhao Y, Li J, Yi K, Feng H, Zhu P, Li B, Liu Q, Fairley S, Magor KE, Du Z, Hu X, Goodman L, Tafer H, Vignal A, Lee T, Kim KW, Sheng Z, An Y, Searle S, Herrero J, Groenen MA, Crooijmans RP, Faraut T, Cai Q, Webster RG, Aldridge JR, Warren WC, Bartschat S, Kehr S, Marz M, Stadler PF, Smith J, Kraus RH, Ren L, Fei J, Morisson M, Kaiser P, Griffin DK, Rao M, Pitel F, Wang J, Li N (- 40)
Ref: Nat Genet, 45:776, 2013 : PubMed
Abstract


ESTHER: Huang_2013_Nat.Genet_45_776
PubMedSearch: Huang 2013 Nat.Genet 45 776
PubMedID: 23749191
Gene_locus related to this paper: anapl-BCHE, anapl-r0lw36, anapl-r0m5n4, anapl-thioe, anapl-u3iqr9, anapl-r0l4n7, anapl-u3j4v8, anapl-u3icy5, anapl-u3ivv9, anapl-u3j4g1, anapl-u3j4i2, anapl-u3j4v5, anapl-r0kv25, anapl-u3ild2, anapl-u3imh5, anapl-b6dzk9, anapl-u3imp7, anapl-u3i5h5, anapl-u3id17, anapl-r0m1y3, anapl-r0lhc4, anapl-r0ktn0, anapl-r0l8l1, anapl-r0lin6, anapl-r0jhf3

Abstract

The duck (Anas platyrhynchos) is one of the principal natural hosts of influenza A viruses. We present the duck genome sequence and perform deep transcriptome analyses to investigate immune-related genes. Our data indicate that the duck possesses a contractive immune gene repertoire, as in chicken and zebra finch, and this repertoire has been shaped through lineage-specific duplications. We identify genes that are responsive to influenza A viruses using the lung transcriptomes of control ducks and ones that were infected with either a highly pathogenic (A/duck/Hubei/49/05) or a weakly pathogenic (A/goose/Hubei/65/05) H5N1 virus. Further, we show how the duck's defense mechanisms against influenza infection have been optimized through the diversification of its beta-defensin and butyrophilin-like repertoires. These analyses, in combination with the genomic and transcriptomic data, provide a resource for characterizing the interaction between host and influenza viruses.