Gene_locus Report for: anoca-nlgn2 Anolis carolinensis (Green anole) (American chameleon) Neuroligin 2
Relationship
(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.) cellular organisms: N E > Eukaryota: N E > Opisthokonta: N E > Metazoa: N E > Eumetazoa: N E > Bilateria: N E > Deuterostomia: N E > Chordata: N E > Craniata: N E > Vertebrata: N E > Gnathostomata: N E > Teleostomi: N E > Euteleostomi: N E > Sarcopterygii: N E > Dipnotetrapodomorpha: N E > Tetrapoda: N E > Amniota: N E > Sauropsida: N E > Sauria: N E > Lepidosauria: N E > Squamata: N E > Bifurcata: N E > Unidentata: N E > Episquamata: N E > Toxicofera: N E > Iguania: N E > Dactyloidae: N E > Anolis: N E > Anolis carolinensis: N E ABHD6-Lip :
anoca-g1k9z1 Anolis carolinensis (Green anole) (American chameleon) Uncharacterized protein ,
anoca-g1kln1 Anolis carolinensis (Green anole) (American chameleon) Uncharacterized protein ,
anoca-g1klq2 Anolis carolinensis (Green anole) (American chameleon) Uncharacterized protein ,
anoca-r4gan7 Anolis carolinensis (Green anole) (American chameleon) Uncharacterized protein ,
anoca-r4gdd2 Anolis carolinensis (Green anole) (American chameleon) Uncharacterized protein .
ABHD10 :
anoca-g1kqp8 Anolis carolinensis (Green anole) (American chameleon). Abhydrolase domain containing 10 .
ABHD12-PHARC :
anoca-g1kpn9 Anolis carolinensis (Green anole) (American chameleon). Uncharacterized protein .
ABHD13-BEM46 :
anoca-g1kpz4 Anolis carolinensis (Green anole) (American chameleon). Hydrolase_4 domain-containing protein .
ABHD16 :
anoca-h9gpa2 Anolis carolinensis (Green anole) (American chameleon). Abhydrolase domain containing 16A .
ABHD18 :
anoca-g1kl71 Anolis carolinensis (Green anole) (American chameleon). Uncharacterized protein ABHD18 .
ACHE :
anoca-ACHE Anolis carolinensis (green anole) (American chameleon) acetylcholinesterase Transcriptome Shotgun Assembly .
Arb2_FAM172A :
anoca-g1knj4 Anolis carolinensis (Green anole) (American chameleon). Uncharacterized protein .
Arylacetamide_deacetylase :
anoca-g1kh99 Anolis carolinensis (Green anole) (American chameleon). Uncharacterized protein ,
anoca-g1ksj9 Anolis carolinensis (Green anole) (American chameleon). Uncharacterized protein ,
anoca-h9g670 Anolis carolinensis (Green anole) (American chameleon). Uncharacterized protein ,
anoca-h9g675 Anolis carolinensis (Green anole) (American chameleon). Uncharacterized protein ,
anoca-h9g680 Anolis carolinensis (Green anole) (American chameleon). Uncharacterized protein ,
anoca-h9gbf2 Anolis carolinensis (Green anole) (American chameleon). Uncharacterized protein ,
anoca-h9gl37 Anolis carolinensis (Green anole) (American chameleon). Uncharacterized protein ,
anoca-h9gq07 Anolis carolinensis (Green anole) (American chameleon). Uncharacterized protein ,
anoca-h9gqa2 Anolis carolinensis (Green anole) (American chameleon). Uncharacterized protein ,
anoca-h9gqv4 Anolis carolinensis (Green anole) (American chameleon). Uncharacterized protein ,
anoca-h9gr08 Anolis carolinensis (Green anole) (American chameleon). Uncharacterized protein .
BCHE :
anoca-BCHE Anolis carolinensis (green anole) (American chameleon) butyrylcholinesterase .
Carboxypeptidase_S10 :
anoca-h9gf35 Anolis carolinensis (Green anole) (American chameleon) Uncharacterized protein .
Carb_B_Chordata :
anoca-h9g4c9 Anolis carolinensis (Green anole) (American chameleon) Uncharacterized protein ,
anoca-h9gb75 Anolis carolinensis (Green anole) (American chameleon) Uncharacterized protein ,
anoca-h9ggh4 Anolis carolinensis (Green anole) (American chameleon) Uncharacterized protein ,
anoca-h9ghc5 Anolis carolinensis (Green anole) (American chameleon) Uncharacterized protein ,
anoca-l7mzq8 Anolis carolinensis (Green anole) (American chameleon) Uncharacterized protein .
Cholesterol_esterase :
anoca-g1kdb8 Anolis carolinensis (Green anole) (American chameleon) Uncharacterized protein .
Cholinesterase-like :
anoca-g1kky5 Anolis carolinensis (Green anole) (American chameleon) Uncharacterized protein ,
anoca-g1kl08 Anolis carolinensis (Green anole) (American chameleon) Uncharacterized protein ,
anoca-g1kl23 Anolis carolinensis (Green anole) (American chameleon) Uncharacterized protein ,
anoca-g1kuy8 Anolis carolinensis (Green anole) (American chameleon) Uncharacterized protein ,
anoca-g1kvs9 Anolis carolinensis (Green anole) (American chameleon) Uncharacterized protein ,
anoca-g1kyz2 Anolis carolinensis (Green anole) (American chameleon) Uncharacterized protein ,
anoca-r4g9q4 Anolis carolinensis (Green anole) (American chameleon) Uncharacterized protein ,
anoca-r4g9w1 Anolis carolinensis (Green anole) (American chameleon) Uncharacterized protein ,
anoca-r4gab8 Anolis carolinensis (Green anole) (American chameleon) Uncharacterized protein ,
anoca-r4gbt6 Anolis carolinensis (Green anole) (American chameleon) Uncharacterized protein .
CIB-CCG1-interacting-factor-B :
anoca-g1klm8 Anolis carolinensis (Green anole) (American chameleon). Uncharacterized protein .
CMBL :
anoca-g1kaz5 Anolis carolinensis (Green anole) (American chameleon). Carboxymethylenebutenolidase homolog .
Hepatic_Lipase :
anoca-h9glr3 Anolis carolinensis (Green anole) (American chameleon). Lipase C, hepatic type .
Kynurenine-formamidase :
anoca-g1ksz5 Anolis carolinensis (Green anole) (American chameleon). N-formylkynurenine formamidase .
Lipoprotein_Lipase :
anoca-g1kpf6 Anolis carolinensis (Green anole) (American chameleon). Lipoprotein lipase ,
anoca-g1kum0 Anolis carolinensis (Green anole) (American chameleon). Lipase G, endothelial type .
Maspardin-ACP33-SPG21_like :
anoca-h9g9d1 Anolis carolinensis (Green anole) (American chameleon) Uncharacterized protein .
Monoglyceridelipase_lysophospholip :
anoca-g1kgg4 Anolis carolinensis (Green anole) (American chameleon). Uncharacterized protein .
Ndr_family :
anoca-h9ght8 Anolis carolinensis (Green anole) (American chameleon) Uncharacterized protein ,
anoca-g1kfn4 Anolis carolinensis (Green anole) (American chameleon) Uncharacterized protein ,
anoca-g1klk6 Anolis carolinensis (Green anole) (American chameleon) Uncharacterized protein .
Neuroligin :
anoca-d2x2h9 Anolis carolinensis (Green anole) (American chameleon) Neuroligin 3 ,
anoca-nlgn4 Anolis carolinensis (Green anole) (American chameleon) Neuroligin 4 .
NLS3-Tex30 :
anoca-g1kbc0 Anolis carolinensis (Green anole) (American chameleon) Uncharacterized protein ,
anoca-h9g5s9 Anolis carolinensis (Green anole) (American chameleon) Uncharacterized protein .
Pancreatic_lipase :
anoca-h9gfq0 Anolis carolinensis (Green anole) (American chameleon). Pancreatic lipase ,
anoca-h9gfy1 Anolis carolinensis (Green anole) (American chameleon). Pancreatic lipase related protein 2 (gene/pseudogene) .
Pectinacetylesterase-Notum :
anoca-g1kjy3 Anolis carolinensis (Green anole) (American chameleon). Uncharacterized protein .
Phospholipase :
anoca-h9g7n4 Anolis carolinensis (Green anole) (American chameleon). Phospholipase A1 member A ,
anoca-h9g3p8 Anolis carolinensis (Green anole) (American chameleon). Lipase domain-containing protein .
Thyroglobulin :
anoca-g1kl79 Anolis carolinensis (Green anole) (American chameleon) Uncharacterized protein .
Valacyclovir-hydrolase :
anoca-h9gpi8 Anolis carolinensis (Green anole) (American chameleon) Uncharacterized protein Molecular evidence
Database
No mutation No structure No kinetic No Substrate No inhibitor
Sequence
Graphical view for this peptide sequence: anoca-nlgn2 Colored MSA for Neuroligin (raw)
MFLSPSSFVLRVLNIRTGSALFFWLLGLALRSLPLSGQKPEDKYPVVPTN
YGKLRGIKKDLNNEILGPVVQYLGIPYATPPVGERRFQPPEAPASWSEVR
NATAFAPVCPQNIHGMLPGIMLPVWFTDNLEIVAGYVQNQSEDCLYLNIY
VPMEDGPLTKKREEASTNNPTPDEDIRDSGKKPVMLFIHGGSYMEGTGNM
FDGSVLAAYGNVIVVTMNYRLGVLGFMSTGDQSAKGNYGLLDQIQALRWL
NENIGHFGGDPERITIFGSGAGASCVNLLILSHHSEGLFQKAIAQSGTAI
SSWSVNYQPLKYTRMLASKVGCDHMDTSNTVDCLRRKPYRELVDQDIQPA
RYHIAFGPVVDGDVVPDDPEILMQQGEFLNYDILIGVNQGEGLKFVEDSM
ENEDGISASYFDFTISNFVDNLYGYPEGKDILRETIKFMYTDWADRDNGE
MRRKTLLALFTDHQWVAPAVATAKLHAEYQSPVYFYTFYHHCQTDTRPEW
ADAAHGDEIPYVFGVPMIGATDLFPCNFSKNDVMLSAVVMTYWTNFAKTG
DPNQPVPQDTKFIHTKPNRFEEVVWTKFNTKDKQYLHIGLKPRVRDNYRA
NKVAFWLELVPHLHNLHEPPYTSTTTRIPPAVTRWPSTGPLTTRRPMPTL
PVDEDDVVRPQRYVPFPGDSRDYSTELSVTVAVGASLLFLNILAFAALYY
KRDKRHELRSGRRLSPQRSAANDLVHGGQEEEIMSLQIKHSEHDAHDLEP
LRPHEILRPACPPDYTLALRRAPDDVPLMTPNTITMIPSTITGMQALHPF
NTFPTGHNNTLPHPHSTTRV
Legend
This sequence has been compared to family alignement (MSA) red => minority aminoacid blue => majority aminoacid color intensity => conservation rate title => sequence position(MSA position)aminoacid rate Catalytic site Catalytic site in the MSA
M F L S P S S F V L R V L N I R T G S A L F F W L L G L A L R S L P L S G Q K P E D K Y P V V P T N Y G K L R G I K K D L N N E I L G P V V Q Y L G I P Y A T P P V G E R R F Q P P E A P A S W S E V R N A T A F A P V C P Q N I H G M L P G I M L P V W F T D N L E I V A G Y V Q N Q S E D C L Y L N I Y V P M E D G P L T K K R E E A S T N N P T P D E D I R D S G K K P V M L F I H G G S Y M E G T G N M F D G S V L A A Y G N V I V V T M N Y R L G V L G F M S T G D Q S A K G N Y G L L D Q I Q A L R W L N E N I G H F G G D P E R I T I F G S G A G A S C V N L L I L S H H S E G L F Q K A I A Q S G T A I S S W S V N Y Q P L K Y T R M L A S K V G C D H M D T S N T V D C L R R K P Y R E L V D Q D I Q P A R Y H I A F G P V V D G D V V P D D P E I L M Q Q G E F L N Y D I L I G V N Q G E G L K F V E D S M E N E D G I S A S Y F D F T I S N F V D N L Y G Y P E G K D I L R E T I K F M Y T D W A D R D N G E M R R K T L L A L F T D H Q W V A P A V A T A K L H A E Y Q S P V Y F Y T F Y H H C Q T D T R P E W A D A A H G D E I P Y V F G V P M I G A T D L F P C N F S K N D V M L S A V V M T Y W T N F A K T G D P N Q P V P Q D T K F I H T K P N R F E E V V W T K F N T K D K Q Y L H I G L K P R V R D N Y R A N K V A F W L E L V P H L H N L H E P P Y T S T T T R I P P A V T R W P S T G P L T T R R P M P T L P V D E D D V V R P Q R Y V P F P G D S R D Y S T E L S V T V A V G A S L L F L N I L A F A A L Y Y K R D K R H E L R S G R R L S P Q R S A A N D L V H G G Q E E E I M S L Q I K H S E H D A H D L E P L R P H E I L R P A C P P D Y T L A L R R A P D D V P L M T P N T I T M I P S T I T G M Q A L H P F N T F P T G H N N T L P H P H S T T R V
Reference
Title: Characterization of the neuroligin gene family expression and evolution in zebrafishRissone A , Sangiorgio L , Monopoli M , Beltrame M , Zucchi I , Bussolino F , Arese M , Cotelli F Ref: Developmental Dynamics, 239 :688, 2010 : PubMed Abstract ESTHER: Rissone_2010_Dev.Dyn_239_688 PubMedSearch: Rissone 2010 Dev.Dyn 239 688 PubMedID: 20034102 Gene_locus related to this paper: anoca-d2x2h9 ,
anoca-nlgn2 ,
anoca-nlgn4 ,
chick-d3wgl5 ,
chick-nlgn1 ,
chick-NLGN3 ,
ciosa-d2x2f8 ,
danre-1neur ,
danre-32neur ,
danre-d2x2g1 ,
danre-d2x2g3 ,
danre-d2x2g5 ,
danre-nlgn2a ,
danre-nlgn4a ,
gasac-d2x2j3 ,
gasac-d2x2j4 ,
gasac-nlgn2a ,
gasac-nlgn2b ,
gasac-nlgn4 ,
human-NLGN1 ,
human-NLGN3 ,
mondo-d2x2i6 ,
mondo-d2x2i8 ,
mondo-d2x2i9 ,
oryla-d2x2i4 ,
oryla-d2x2i5 ,
oryla-nlgn2 ,
takru-1neur ,
takru-2bneur ,
takru-3bneur ,
takru-nlgn2a ,
takru-nlgn3a ,
takru-nlgn4a ,
tetng-3neur ,
tetng-4neur ,
tetng-nlgn2b ,
tetng-nlgn2a ,
tetng-nlgn3b ,
xentr-d2x2k4 ,
xentr-d2x2k6 ,
xentr-d2x2k7 Abstract
Neuroligins constitute a family of transmembrane proteins localized at the postsynaptic side of both excitatory and inhibitory synapses of the central nervous system. They are involved in synaptic function and maturation and recent studies have linked mutations in specific human Neuroligins to mental retardation and autism. We isolated the human Neuroligin homologs in Danio rerio. Next, we studied their gene structures and we reconstructed the evolution of the Neuroligin genes across vertebrate phyla. Using reverse-transcriptase polymerase chain reaction, we analyzed the expression and alternative splicing pattern of each gene during zebrafish embryonic development and in different adult organs. By in situ hybridization, we analyzed the temporal and spatial expression pattern during embryonic development and larval stages and we found that zebrafish Neuroligins are expressed throughout the nervous system. Globally, our results indicate that, during evolution, specific subfunctionalization events occurred within paralogous members of this gene family in zebrafish.
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