Gene_locus Report for: artan-a0a2u1l9j8

(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)
> cellular organisms: N E > Eukaryota: N E > Viridiplantae: N E > Streptophyta: N E > Streptophytina: N E > Embryophyta: N E > Tracheophyta: N E > Euphyllophyta: N E > Spermatophyta: N E > Magnoliophyta: N E > Mesangiospermae: N E > eudicotyledons: N E > Gunneridae: N E > Pentapetalae: N E > asterids: N E > campanulids: N E > Asterales: N E > Asteraceae: N E > Asteroideae: N E > Anthemideae: N E > Artemisiinae: N E > Artemisia: N E > Artemisia annua: N E

Title: The Genome of Artemisia annua Provides Insight into the Evolution of Asteraceae Family and Artemisinin Biosynthesis
Shen Q, Zhang L, Liao Z, Wang S, Yan T, Shi P, Liu M, Fu X, Pan Q and Tang K <15 more author(s)> Shen Q, Zhang L, Liao Z, Wang S, Yan T, Shi P, Liu M, Fu X, Pan Q, Wang Y, Lv Z, Lu X, Zhang F, Jiang W, Ma Y, Chen M, Hao X, Li L, Tang Y, Lv G, Zhou Y, Sun X, Brodelius PE, Rose JKC, Tang K (- 15)
Ref: Mol Plant, 11:776, 2018 : PubMed
Abstract


ESTHER: Shen_2018_Mol.Plant_11_776
PubMedSearch: Shen 2018 Mol.Plant 11 776
PubMedID: 29703587
Gene_locus related to this paper: artan-a0a2u1ns65, artan-a0a2u1nuf0, artan-a0a2u1pw87, artan-a0a2u1ql98, artan-a0a2u1n9p7.2, artan-a0a2u1ky94, artan-a0a2u1pvq0, artan-a0a2u1q8x4, artan-a0a2u1mtd1, artan-a0a2u1l9j8, artan-a0a2u1lak5, artan-a0a2u1lfl1, artan-a0a2u1lzs1, artan-a0a2u1m5v6, artan-a0a2u1n4s5, artan-a0a2u1qgg7

Abstract

Artemisia annua, commonly known as sweet wormwood or Qinghao, is a shrub native to China and has long been used for medicinal purposes. A. annua is now cultivated globally as the only natural source of a potent anti-malarial compound, artemisinin. Here, we report a high-quality draft assembly of the 1.74-gigabase genome of A. annua, which is highly heterozygous, rich in repetitive sequences, and contains 63 226 protein-coding genes, one of the largest numbers among the sequenced plant species. We found that, as one of a few sequenced genomes in the Asteraceae, the A. annua genome contains a large number of genes specific to this large angiosperm clade. Notably, the expansion and functional diversification of genes encoding enzymes involved in terpene biosynthesis are consistent with the evolution of the artemisinin biosynthetic pathway. We further revealed by transcriptome profiling that A. annua has evolved the sophisticated transcriptional regulatory networks underlying artemisinin biosynthesis. Based on comprehensive genomic and transcriptomic analyses we generated transgenic A. annua lines producing high levels of artemisinin, which are now ready for large-scale production and thereby will help meet the challenge of increasing global demand of artemisinin.