(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.) > cellular organisms: NE > Eukaryota: NE > Opisthokonta: NE > Fungi: NE > Dikarya: NE > Ascomycota: NE > saccharomyceta: NE > Pezizomycotina: NE > leotiomyceta: NE > Eurotiomycetes: NE > Eurotiomycetidae: NE > Eurotiales: NE > Aspergillaceae: NE > Aspergillus: NE > Aspergillus fumigatus: NE
Warning: This entry is a compilation of different species or line or strain with more than 90% amino acid identity. You can retrieve all strain data
(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.) Aspergillus fumigatus Af293: N, E.
Neosartorya fumigata: N, E.
Aspergillus fumigatus var. RP-2014: N, E.
Aspergillus fumigatus A1163: N, E.
Aspergillus fumigatus Z5: N, E.
Neosartorya fischeri NRRL 181: N, E.
LegendThis sequence has been compared to family alignement (MSA) red => minority aminoacid blue => majority aminoacid color intensity => conservation rate title => sequence position(MSA position)aminoacid rate Catalytic site Catalytic site in the MSA MLFGSVASTALLALSLCLDSASAAKHGRFGQKARDSLAKRSSSSLVTHEP ETRSRHKDFRFLNKDTKPYLVKSLPDVKFDIGEMYSGSVPIDKGNKSREL FFIFQPTIGEPVDEVTIWLNGGPGCSSLEGFFQENGRFTWQPGTLAPVEN PYSWVNLTNMLWVDQPVGTGFATGKPTATSQEEIAEDFIKFFKNFQEIFG IKNYKIYVTGESYAGRYVPYISAAMLDQNDTEYYDLKGALVYDPCIGQFD YVQEEVPAVPFVQQNANLFNFNASFMAELERLHQTCGYQDFIDKYLVFPP SGVQPPKMFNYTSDAECDVFDMIKTAAMAVNPCFDIYEINLMCPLAWDVL AFPTELVYQPAGATVYFDREDVKRALHAPSIKWAECADEAVFVGGSGGPE QEGDFSANPIEHVLPQVIEATNRVLVSNGDYDMIILTNGTLLAIQNMTWH GQLGFQSAPSTPITITLPDLHYADVYAENQMTGVDGAQGVMGVQHYERGL MWAETYQSGHMQPQYQPRVTYRHLQWLLGHIESL
References
Title: Discovery of a sexual cycle in the opportunistic fungal pathogen Aspergillus fumigatus O'Gorman CM, Fuller H, Dyer PS Ref: Nature, 457:471, 2009 : PubMed
Aspergillus fumigatus is a saprotrophic fungus whose spores are ubiquitous in the atmosphere. It is also an opportunistic human pathogen in immunocompromised individuals, causing potentially lethal invasive infections, and is associated with severe asthma and sinusitis. The species is only known to reproduce by asexual means, but there has been accumulating evidence for recombination and gene flow from population genetic studies, genome analysis, the presence of mating-type genes and expression of sex-related genes in the fungus. Here we show that A. fumigatus possesses a fully functional sexual reproductive cycle that leads to the production of cleistothecia and ascospores, and the teleomorph Neosartorya fumigata is described. The species has a heterothallic breeding system; isolates of complementary mating types are required for sex to occur. We demonstrate increased genotypic variation resulting from recombination between mating type and DNA fingerprint markers in ascospore progeny from an Irish environmental subpopulation. The ability of A. fumigatus to engage in sexual reproduction is highly significant in understanding the biology and evolution of the species. The presence of a sexual cycle provides an invaluable tool for classical genetic analyses and will facilitate research into the genetic basis of pathogenicity and fungicide resistance in A. fumigatus, with the aim of improving methods for the control of aspergillosis. These results also yield insights into the potential for sexual reproduction in other supposedly 'asexual' fungi.
Aspergillus fumigatus is exceptional among microorganisms in being both a primary and opportunistic pathogen as well as a major allergen. Its conidia production is prolific, and so human respiratory tract exposure is almost constant. A. fumigatus is isolated from human habitats and vegetable compost heaps. In immunocompromised individuals, the incidence of invasive infection can be as high as 50% and the mortality rate is often about 50% (ref. 2). The interaction of A. fumigatus and other airborne fungi with the immune system is increasingly linked to severe asthma and sinusitis. Although the burden of invasive disease caused by A. fumigatus is substantial, the basic biology of the organism is mostly obscure. Here we show the complete 29.4-megabase genome sequence of the clinical isolate Af293, which consists of eight chromosomes containing 9,926 predicted genes. Microarray analysis revealed temperature-dependent expression of distinct sets of genes, as well as 700 A. fumigatus genes not present or significantly diverged in the closely related sexual species Neosartorya fischeri, many of which may have roles in the pathogenicity phenotype. The Af293 genome sequence provides an unparalleled resource for the future understanding of this remarkable fungus.
Aspergillus fumigatus Af293 and Neosartorya fumigata (strain CEA10 / CBS 144.89 / FGSC A1163) (Aspergillus fumigatus) Siderophore esterase IroE-like AfEstB