Gene_Locus Report

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Gene_locus Report for: asptn-LOVG

Aspergillus terreus (strain NIH 2624 / FGSC A1156) Esterase LovG

Relationship
Family|FSH1
Block| X
Position in NCBI Life Tree|Aspergillus terreus
(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)
> cellular organisms: N E > Eukaryota: N E > Opisthokonta: N E > Fungi: N E > Dikarya: N E > Ascomycota: N E > saccharomyceta: N E > Pezizomycotina: N E > leotiomyceta: N E > Eurotiomycetes: N E > Eurotiomycetidae: N E > Eurotiales: N E > Aspergillaceae: N E > Aspergillus: N E > Aspergillus terreus: N E


Molecular evidence
Database
No mutation
No structure
No kinetic





No Substrate
No inhibitor
2 Genbank : EAU29411, XP_001209264
1 UniProt : Q0C8M2
1 UniProt : Q0C8M2
1 Interpro : Q0C8M2
1 Prodom : Q0C8M2
1 Pfam : Q0C8M2
1 PIRSF : Q0C8M2
1 SUPERFAM : Q0C8M2
Sequence
Graphical view for this peptide sequence: asptn-LOVG
Colored MSA for FSH1 (raw)
MRYQASPALAKAPRALLCIHGAGCSPAIFRVQLSKLRAALREDFEFVYVT
APFPSSAGPGILPVFADLGPYYSWFESSSGNNNNGPSVGERLAAVHDPIR
RTIVDWQTQHPHIPIVGAIGFSEGALVTTLLLWQQQMGRLPWLPRMSVAM
LICPWYQDEASQYMRNEVMENHDDDHDSKDTEWQEELVIRIPTLHLQGRD
DFALAGSKMLVARHFSPREAQVLEFAGQHQFPNRPRDVLEVINRFRKLCV
TVQTLE
Legend This sequence has been compared to family alignement (MSA)
red => minority aminoacid
blue => majority aminoacid
color intensity => conservation rate
title => sequence position(MSA position)aminoacid rate
Catalytic site
Catalytic site in the MSA

MRYQASPALAKAPRALLCIHGAGCSPAIFRVQLSKLRAALREDFEFVYVT
APFPSSAGPGILPVFADLGPYYSWFESSSGNNNNGPSVGERLAAVHDPIR
RTIVDWQTQHPHIPIVGAIGFSEGALVTTLLLWQQQMGRLPWLPRMSVAM
LICPWYQDEASQYMRNEVMENHDDDHDSKDTEWQEELVIRIPTLHLQGRD
DFALAGSKMLVARHFSPREAQVLEFAGQHQFPNRPRDVLEVINRFRKLCV
TVQTLE


Reference
    Title: LovG: the thioesterase required for dihydromonacolin L release and lovastatin nonaketide synthase turnover in lovastatin biosynthesis
    Xu W, Chooi YH, Choi JW, Li S, Vederas JC, Da Silva NA, Tang Y
    Ref: Angew Chem Int Ed Engl, 52:6472, 2013 : PubMed

            


Other Papers


Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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