Gene_locus Report for: bacan-BA1914

AE017355 Q6HK39 Bacillus thuringiensis 5aa diff

(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)
> cellular organisms: N E > Bacteria: N E > Terrabacteria group: N E > Firmicutes: N E > Bacilli: N E > Bacillales: N E > Bacillaceae: N E > Bacillus: N E > Bacillus cereus group: N E > Bacillus anthracis: N E

6_AlphaBeta_hydrolase : bacan-BA0160Bacillus anthracis (strain Ames) and Bacillus thuringiensis (subsp. konkukian) hypothetical protein, bacan-BA0954Bacillus anthracis, Bacillus thuringiensis, Lysinibacillus sphaericus, Bacillus cereus; Bacillus mycoides, Bacillus weihenstephanensis, Bifunctional nucleotide sugar epimerase/hydrolase mxaa domain protein, bacan-BA1747Bacillus anthracis (strain Ames) hydrolase, alpha/beta fold family, bacan-BA2015Bacillus anthracis (strain Ames) hypothetical protein, bacan-BA2417Bacillus anthracis (strain Ames) hydrolase, alpha/beta fold family, bacan-BA2557Bacillus anthracis (strain Ames) hypothetical protein, bacan-BA2687 Bacillus anthracis (strain Ames) hydrolase, and Bacillus cereus (strain ATCC 10987) alpha/beta fold family, bacan-BA2865Bacillus anthracis (strain Ames) Bacillus cereus MM3 hypothetical protein, bacan-BA3068Bacillus anthracis (strain Ames) hypothetical protein, bacan-BA3187Bacillus anthracis (strain Ames) hydrolase, alpha/beta fold family, bacan-BA3343Bacillus anthracis (strain Ames) Bacillus thuringiensis (strain Al Hakam) (subsp. konkukian)Bacillus cereus (strain ATCC 10987)hydrolase, alpha/beta fold family, bacan-BA3372Bacillus anthracis (strain Ames) hypothetical protein, bacan-BA3877Bacillus anthracis (strain Ames) and Bacillus thuringiensis (subsp. konkukian) (strain Al Hakam) hydrolase, alpha/beta fold family, bacan-BA3887Bacillus anthracis (strain Ames)Bacillus cereus G9241 hydrolase, alpha/beta fold family.
A85-IroE-IroD-Fes-Yiel : bacan-BA1242Bacillus anthracis, Bacillus thuringiensis, hypothetical protein, bacan-BA2694Bacillus anthracis (strain Ames)Bacillus thuringiensis serovar kurstaki str. T03a001 Bacillus cereus ATCC 10876 esterase, putative, bacan-BA3863Bacillus anthracis; Bacillus thuringiensis, Bacillus cereus, hypothetical protein.
Aclacinomycin-methylesterase_RdmC : bacan-BA2738Bacillus anthracis, Bacillus thuringiensis, Bacillus cereus, hydrolase, alpha/beta fold family.
AlphaBeta_hydrolase : bacan-BA1019Bacillus anthracis, Bacillus thuringiensis, Bacillus cereus, Bacillus thuringiensis hydrolase, alpha/beta fold family, bacan-BA3178Bacillus anthracis; Bacillus thuringiensis; Bacillus cereus; Bacillus weihenstephanensis hypothetical protein, bacan-BA4328Bacillus anthracis (strain Ames) hypothetical protein, bacan-BA4577Bacillus anthracis; Bacillus thuringiensis; Bacillus cereus; hydrolase, alpha/beta fold family.
Bacillus_lip : bacan-q81tt2Bacillus anthracis. hypothetical protein.
Bacterial_EstLip_FamX : bacan-BA1866Bacillus anthracis Bacillus cereus hypothetical protein.
Bacterial_lip_FamI.5 : bacan-BA2607Bacillus anthracis, Bacillus thuringiensis, Bacillus cereus lipase, putative.
BlEst2-lipase-like : bacan-a0a6l7h3w8Bacillus anthracis. Uncharacterized protein.
Carbon-carbon_bond_hydrolase : bacan-BA5136Bacillus anthracis (strain Ames) Bacillus thuringiensis (subsp. konkukian) (strain Al Hakam) Bacillus cereus G9241 hydrolase, alpha/beta fold family.
Homoserine_transacetylase : bacan-BA4983 Bacillus anthracis, Bacillus cereus, Homoserine O-acetyltransferase, putative.
LYsophospholipase_carboxylesterase : bacan-BA3703Bacillus anthracis, Bacillus thuringiensis, Bacillus cereus, phospholipase/carboxylesterase family protein.
MenH_SHCHC : bacan-BA5110Bacillus anthracis, Bacillus thuringiensis, Bacillus cereus, hydrolase, alpha/beta fold family.
Monoglyceridelipase_lysophospholip : bacan-BA5009Bacillus anthracis, Bacillus cereus, Bacillus thuringiensis, Bacillus weihenstephanensis lysophospholipase l2 (EC 3.1.1.5).
PAF-Acetylhydrolase : bacan-BA0950Bacillus anthracis (strain Ames) and Bacillus thuringiensis (subsp. konkukian)hypothetical protein.
PC-sterol_acyltransferase : bacan-BA3805Bacillus anthracis prophage lambdaba01, acyltransferase, putative.
Proline_iminopeptidase : bacan-BA2392Bacillus anthracis; Bacillus thuringiensis, Bacillus cereus, Bacillus weihenstephanensis, Bacillus mycoides, Proline_iminopeptidase, bacan-BA4324Bacillus anthracis, Bacillus thuringiensis, Bacillus cereus, hydrolase.
Thioesterase : bacan-DHBFBacillus anthracis, Bacillus thuringiensis, Bacillus mycoides, Bacillus weihenstephanensis, nonribosomal peptide synthetase dhbf Thioesterase domain.
UCP033634 : bacan-Q81NX8Bacillus anthracis Uncharacterized protein, bacan-a0a1j9w4y5Bacillus anthracis; Bacillus sp.; Bacillus cereus Uncharacterized protein, bacan-a0a1j9wz46Bacillus anthracis Uncharacterized protein, bacan-a0a1t3uyy1Bacillus anthracis Alpha/beta hydrolase, bacan-a0a2a8lbn0Bacillus anthracis Alpha/beta hydrolase, bacan-a0a2a8wij7Bacillus anthracis; Bacillus cereus Alpha/beta hydrolase, bacan-a0a2b0y5d8Bacillus anthracis Uncharacterized protein, bacan-a0a2b8ijf1Bacillus anthracis Alpha/beta hydrolase

Title: The genome sequence of Bacillus anthracis Ames and comparison to closely related bacteria
Read TD, Peterson SN, Tourasse N, Baillie LW, Paulsen IT, Nelson KE, Tettelin H, Fouts DE, Eisen JA and Fraser CM <42 more author(s)> Read TD, Peterson SN, Tourasse N, Baillie LW, Paulsen IT, Nelson KE, Tettelin H, Fouts DE, Eisen JA, Gill SR, Holtzapple EK, Okstad OA, Helgason E, Rilstone J, Wu M, Kolonay JF, Beanan MJ, Dodson RJ, Brinkac LM, Gwinn M, DeBoy RT, Madpu R, Daugherty SC, Durkin AS, Haft DH, Nelson WC, Peterson JD, Pop M, Khouri HM, Radune D, Benton JL, Mahamoud Y, Jiang L, Hance IR, Weidman JF, Berry KJ, Plaut RD, Wolf AM, Watkins KL, Nierman WC, Hazen A, Cline R, Redmond C, Thwaite JE, White O, Salzberg SL, Thomason B, Friedlander AM, Koehler TM, Hanna PC, Kolsto AB, Fraser CM (- 42)
Ref: Nature, 423:81, 2003 : PubMed
Abstract


ESTHER: Read_2003_Nature_423_81
PubMedSearch: Read 2003 Nature 423 81
PubMedID: 12721629
Gene_locus related to this paper: bacan-BA0160, bacan-BA0950, bacan-BA0954, bacan-BA1019, bacan-BA1242, bacan-BA1727, bacan-BA1747, bacan-BA1866, bacan-BA1914, bacan-BA2015, bacan-BA2392, bacan-BA2417, bacan-BA2557, bacan-BA2607, bacan-BA2687, bacan-BA2694, bacan-BA2738, bacan-BA2865, bacan-BA3068, bacan-BA3165, bacan-BA3178, bacan-BA3187, bacan-BA3343, bacan-BA3372, bacan-BA3703, bacan-BA3805, bacan-BA3863, bacan-BA3877, bacan-BA3887, bacan-BA4324, bacan-BA4328, bacan-BA4338, bacan-BA4577, bacan-BA4983, bacan-BA5009, bacan-BA5110, bacan-BA5136, bacan-DHBF, bacan-q81tt2, bacce-BC0192, bacce-BC1788, bacce-BC1954, bacce-BC2141, bacce-BC2171, bacce-BC4730, bacce-BC4862, bacce-BC5130, bacce-PHAC, bacce-q72yu1, baccr-pepx

Abstract

Bacillus anthracis is an endospore-forming bacterium that causes inhalational anthrax. Key virulence genes are found on plasmids (extra-chromosomal, circular, double-stranded DNA molecules) pXO1 (ref. 2) and pXO2 (ref. 3). To identify additional genes that might contribute to virulence, we analysed the complete sequence of the chromosome of B. anthracis Ames (about 5.23 megabases). We found several chromosomally encoded proteins that may contribute to pathogenicity--including haemolysins, phospholipases and iron acquisition functions--and identified numerous surface proteins that might be important targets for vaccines and drugs. Almost all these putative chromosomal virulence and surface proteins have homologues in Bacillus cereus, highlighting the similarity of B. anthracis to near-neighbours that are not associated with anthrax. By performing a comparative genome hybridization of 19 B. cereus and Bacillus thuringiensis strains against a B. anthracis DNA microarray, we confirmed the general similarity of chromosomal genes among this group of close relatives. However, we found that the gene sequences of pXO1 and pXO2 were more variable between strains, suggesting plasmid mobility in the group. The complete sequence of B. anthracis is a step towards a better understanding of anthrax pathogenesis.