bovin-ppt

 
Bos taurus palmitoyl-protein thioesterase mRNA, complete cds

Relationship
Block X
Bos taurus position in NCBI Life Tree :
N link to NCBI taxonomic web page and E link to ESTHER gene locus found in this strain.
> cellular organisms: N E > Eukaryota: N E > Opisthokonta: N E > Metazoa: N E > Eumetazoa: N E > Bilateria: N E > Deuterostomia: N E > Chordata: N E > Craniata: N E > Vertebrata: N E > Gnathostomata: N E > Teleostomi: N E > Euteleostomi: N E > Sarcopterygii: N E > Dipnotetrapodomorpha: N E > Tetrapoda: N E > Amniota: N E > Mammalia: N E > Theria: N E > Eutheria: N E > Boreoeutheria: N E > Laurasiatheria: N E > Cetartiodactyla: N E > Ruminantia: N E > Pecora: N E > Bovidae: N E > Bovinae: N E > Bos: N E > Bos taurus: N E

Molecular evidence
Database
No mutation
3 structures: 1EI9, 1EH5, 1EXW
No kinetic


Inhibitor: Palmitate , HDSF ,
2 Genbank : L34261, U89646
1 UniProt : P45478
1 Ncbi-nid : 533782
1 Ncbi-pid : 533783
3 Structure : 1EI9, 1EH5, 1EXW
2 UniProtTrembl : P45478, P79349
2 Interpro : P45478, P79349
2 Prodom : P45478, P79349
2 Pfam : P45478, P79349
2 PIRSF : P45478, P79349
2 SUPERFAM : P45478, P79349
2 QuickSwissBlast : P45478, P79349
 
Sequence
Graphical view for this peptide sequence: bovin-ppt
Colored MSA for Palmitoyl-protein_thioesterase (raw)
MASSSCLWLLALAFLLGSCASLALGHLDPPAPLPLVIWHGMGDSCCNPLS
MGAIKKMVEKKIPGIHVLSLEIGKTLREDVENSFFLNVNSQVTTVCQILA
KDPKLQQGYNAMGFSQGGQFLRAVAQRCPSPPMVNLISVGGQHQGVFGLP
RCPGESSHICDFIRKTLNAGAYNKAIQERLVQAEYWHDPIREDIYRNHSI
FLADINQERGVNESYKKNLMALKKFVMVKFLNDTIVDPVDSEWFGFYRSG
QAKETIPLQESTLYTQDRLGLKAMDKAGQLVFLALEGDHLQLSEEWFYAH
IIPFLE
Legend This sequence has been compared to family alignement (MSA)
red => minority aminoacid
blue => majority aminoacid
color intensity => conservation rate
title => sequence position(MSA position)aminoacid rate
Catalytic site
Catalytic site in the MSA

MASSSCLWLLALAFLLGSCASLALGHLDPPAPLPLVIWHGMGDSCCNPLS
MGAIKKMVEKKIPGIHVLSLEIGKTLREDVENSFFLNVNSQVTTVCQILA
KDPKLQQGYNAMGFSQGGQFLRAVAQRCPSPPMVNLISVGGQHQGVFGLP
RCPGESSHICDFIRKTLNAGAYNKAIQERLVQAEYWHDPIREDIYRNHSI
FLADINQERGVNESYKKNLMALKKFVMVKFLNDTIVDPVDSEWFGFYRSG
QAKETIPLQESTLYTQDRLGLKAMDKAGQLVFLALEGDHLQLSEEWFYAH
IIPFLE

Graphical view for this nucleotide DNA sequence (2072 bp): bovin-ppt



References
    Title: The crystal structure of palmitoyl protein thioesterase 1 and the molecular basis of infantile neuronal ceroid lipofuscinosis
    Bellizzi JJ, 3rd, Widom J, Kemp C, Lu JY, Das AK, Hofmann SL, Clardy J
    Ref: Proc Natl Acad Sci U S A, 97:4573, 2000 : PubMed

            

    Title: Lysosomal targeting of palmitoyl-protein thioesterase
    Verkruyse LA, Hofmann SL
    Ref: Journal of Biological Chemistry, 271:15831, 1996 : PubMed

            

    Title: Molecular cloning and expression of palmitoyl-protein thioesterase
    Camp LA, Verkruyse LA, Afendis SJ, Slaughter CA, Hofmann SL
    Ref: Journal of Biological Chemistry, 269:23212, 1994 : PubMed

            


Other Papers


Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
For technical information about these pages see:
ESTHER Home Page and ACEDB Home Page
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