Gene_locus Report for: caeel-K01A2.5

Caenorhabditis elegans k01a2.5 protein

Relationship

Family	\|	Valacyclovir-hydrolase
Block	\|	X
Position in NCBI Life Tree	\|	Caenorhabditis elegans

(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)
> cellular organisms: N E > Eukaryota: N E > Opisthokonta: N E > Metazoa: N E > Eumetazoa: N E > Bilateria: N E > Protostomia: N E > Ecdysozoa: N E > Nematoda: N E > Chromadorea: N E > Rhabditida: N E > Rhabditoidea: N E > Rhabditidae: N E > Peloderinae: N E > Caenorhabditis: N E > Caenorhabditis elegans: N E

There are 179 a/b hydrolases in Caenorhabditis elegans view in a: Table

6_AlphaBeta_hydrolase : caeel-C50B6.9Caenorhabditis elegans c50b6.9 protein.
A85-EsteraseD-FGH : caeel-Y48G10A.1Caenorhabditis elegans y48g10a.1 protein S-formylglutathione hydrolase.
ABHD11-Acetyl_transferase : caeel-F32B4.6Caenorhabditis elegans f32b4.6 protein, caeel-R05D7.4Caenorhabditis elegans R05D7.4 protein.
ABHD12-PHARC : caeel-Y97E10AL.2Caenorhabditis elegans hypothetical protein y97e10al.2.
ABHD16 : caeel-ypt1Caenorhabditis elegans hypothetical 54.7 kda protein f37a4.1 in chromosome III.
ABHD17-depalmitoylase : caeel-F01D5.7Caenorhabditis elegans f01d5.7 protein, caeel-F01D5.8Caenorhabditis elegans f01d5.8 protein, caeel-K04G2.2Caenorhabditis elegans k04g2.2 protein, caeel-q5fc17Caenorhabditis elegans. hypothetical protein, caeel-Y71G12A.4Caenorhabditis elegans hypothetical protein.
ABHD18 : caeel-C54G4.7Caenorhabditis elegans c54g4.7 protein.
abh_upf0017 : caeel-Y60A3A.7Caenorhabditis elegans y60a3a.7 protein, caeel-yyc5Caenorhabditis elegans hypothetical 42.3 kda protein c44c1.5 in chromosome x.
ACHE : caeel-ACHE1Caenorhabditis elegans (N2) ace-1 mRNA for acetylcholinesterase, caeel-ACHE2Caenorhabditis elegans acetylcholinesterase (ace-2) mRNA, cds, caeel-ACHE3Caenorhabditis elegans acetylcholinesterase ace-3 (ace-y) mRNA, partial cds, caeel-ACHE4Caenorhabditis elegans acetylcholinesterase ace-4 (ace-x).
Acidic_Lipase : caeel-1llipCaenorhabditis elegans similar to lysosomal acid lipases lipl-5, caeel-F01G10.7Caenorhabditis elegans f01g10.7 protein, caeel-F46B6.8Caenorhabditis elegans f46b6.8 protein, caeel-F54F3.3Caenorhabditis elegans f54f3.3 protein, caeel-K04A8.5Caenorhabditis elegans similar to triacylglycerol lipase, caeel-R11G11.14Caenorhabditis elegans similar to lipase, caeel-Y50E8A.7Caenorhabditis elegans Y50E8A.7, caeel-Y57E12B.3Caenorhabditis elegans hypothetical 77.3 kda protein LIPL-6.
ACPH_Peptidase_S9 : caeel-R11E3.8Caenorhabditis elegans hypothetical protein.
Acyl-CoA_Thioesterase : caeel-C31H5.6Caenorhabditis elegans c31h5.6 protein, caeel-K05B2.4Caenorhabditis elegans hypothetical 43.5 kda protein, caeel-T05E7.1Caenorhabditis elegans t05e7.1 protein, caeel-W03D8.8Caenorhabditis elegans w03d8.8 protein.
Arb2_FAM172A : caeel-f172aCaenorhabditis elegans. FAM172 family protein homolog Y75B8A.31.
Arylacetamide_deacetylase : caeel-f16f9.4Caenorhabditis elegans CELF16F9 GDXG lipolytic enzyme chromosomeX, caeel-f27c8.6Caenorhabditis elegans locus CEF27C8 F27C8.6 similar to esterase, caeel-t09b9.1Caenorhabditis elegans serine esterase from cosmid T09B9, caeel-Y43F8A.3Caenorhabditis elegans y43f8a.3 protein.
BD-FAE : caeel-D2024.2Caenorhabditis elegans hypothetical protein.
Carboxypeptidase_S10 : caeel-c08h9.1Caenorhabditis elegans cosmid C08H9, comp. sequence, caeel-f13d12.6Caenorhabditis elegans cosmid F13D12, comp. sequence, caeel-f32a5.3Caenorhabditis elegans putative serine carboxypeptidase (EC 3.4.16.-) cosmid F32A5, caeel-f41c3.5Caenorhabditis elegans cosmid F41C3, caeel-k10b2.2Caenorhabditis elegans cosmid K10B2, caeel-K10C2.1.1Caenorhabditis elegans k10c2.1 protein, caeel-K10C2.1.2Caenorhabditis elegans k10c2.1 protein, caeel-K10C2.1.3Caenorhabditis elegans k10c2.1 protein, caeel-K10C2.1.4Caenorhabditis elegans k10c2.1 protein, caeel-Y16B4A.2Caenorhabditis elegans y16b4a.2 protein Carboxypeptidase, caeel-Y32F6A.5Caenorhabditis elegans Y32F6A.5 protein, caeel-Y40D12A.2Caenorhabditis elegans y40d12a.2 protein.
Carb_B_Nematoda : caeel-b0238.1Caenorhabditis elegans carboxylesterase B0238_1, caeel-b0238.2Caenorhabditis elegans carboxylesterase B0238_2, caeel-b0238.7Caenorhabditis elegans carboxylesterase B0238_7, caeel-c01b10.4Caenorhabditis elegans cosmid C01B10, caeel-c01b10.10Caenorhabditis elegans carboxylesterase c01b10_10, caeel-c17h12.4Caenorhabditis elegans cosmid C17H12, caeel-c23h4.2Caenorhabditis elegans carboxylesterase C23H4_2, caeel-c23h4.3Caenorhabditis elegans carboxylesterase C23H4_3, caeel-c23h4.4Caenorhabditis elegans carboxylesterase C23H4_4a, caeel-c23h4.7Caenorhabditis elegans carboxylesterase C23H4_7, caeel-c42d4.2Caenorhabditis elegans carboxylesterase C42D4_2, caeel-C52A10.1Caenorhabditis elegans C52A10.1 gene CE20590, caeel-E01G6.3Caenorhabditis elegans carboxylesterase E01G6_3, caeel-esterCaenorhabditis elegans gene for esterase CM06B1.5 chromosomeV F13H6.3, caeel-f15a8.6Caenorhabditis elegans type-B carboxylesterase/lipase F15A8_6, caeel-f55f3.cCaenorhabditis elegans F55F3.c ESTERASE F55F3.2, caeel-f56c11.6Caenorhabditis elegans cosmid F56C11, caeel-ges1eCaenorhabditis elegans gene for gut esterase (ges1) R12A1.4, caeel-k07c11.4Caenorhabditis elegans carboxylesterase K07C11_4, caeel-k11g9.1Caenorhabditis elegans carboxylesterase K11G9_1, caeel-k11g9.2Caenorhabditis elegans carboxylesterase K11G9_2, caeel-t02b5.1Caenorhabditis elegans carboxylesterase T02B5_1 cest-1.1, caeel-t02b5.3Caenorhabditis elegans carboxylesterase T02B5.3 cest-1.2, caeel-T07H6.1Caenorhabditis elegans proteine T07H6.1 from cosmid T07H6, caeel-t22d1.11Caenorhabditis elegans cosmid T22D1 gene T22D1.11, caeel-t28c12.4Caenorhabditis elegans carboxylesterase T28C12_4, caeel-Y71H2AM.KCaenorhabditis elegans Y71H2AM.13, Y71H2AM.K, caeel-zc376.1Caenorhabditis elegans carboxylesterase ZC376_1, caeel-zc376.2Caenorhabditis elegans carboxylesterase ZC376_2 CEST-2.2, caeel-zc376.3Caenorhabditis elegans carboxylesterase ZC376_3.
CGI-58_ABHD5_ABHD4 : caeel-C25A1.12Caenorhabditis elegans c25a1.12 protein, caeel-C37H5.2Caenorhabditis elegans similar to acetyltransferases, caeel-C37H5.3Caenorhabditis elegans Abhydrolase domain-containing protein abhd-5.2.
CIB-CCG1-interacting-factor-B : caeel-Y55F3AM.10Caenorhabditis elegans hypothetical protein.
Dienelactone_hydrolase : caeel-D1022.3Caenorhabditis elegans on cosmid d1022, caeel-D1022.4Caenorhabditis elegans on cosmid d1022, caeel-q7m3k8Caenorhabditis elegans protein K02A2.1, caeel-T23F4.3Caenorhabditis elegans t23f4.3 DLH domain-containing protein.
DPP4N_Peptidase_S9 : caeel-C27C12.7Caenorhabditis elegans c27c12.7 protein, caeel-K02F2.1Caenorhabditis elegans k02f2.1 protein, caeel-T23F1.7Caenorhabditis elegans t23f1.7 Protein DPF-1.
Duf_676 : caeel-C09D4.4Caenorhabditis elegans hypothetical 103.1 kda protein c09d4.4b c09d4.4c.
Duf_726 : caeel-tmco4Caenorhabditis elegans Uncharacterized membrane protein F35D11.3.
Duf_829 : caeel-q9tzh8Caenorhabditis elegans Putative uncharacterized protein T10B11.6, caeel-q9tzh9Caenorhabditis elegans Putative uncharacterized protein T10B11.5, caeel-q17846Caenorhabditis elegans Putative uncharacterized protein C09B8.4, caeel-q22750Caenorhabditis elegans Protein T24H10.4, partially confirmed by transcript evidence.
Duf_1057 : caeel-C31H5.1Caenorhabditis elegans c31h5.1 protein, caeel-F10D2.10Caenorhabditis elegans hypothetical protein f10d2.10, caeel-F35H12.5Caenorhabditis elegans hypothetical YL4M 40.5 kda protein, caeel-K08D9.4Caenorhabditis elegans k08d9.4 protein, caeel-Y73C8B.1Caenorhabditis elegans hypothetical protein y73c8b.1, caeel-Y73C8B.2Caenorhabditis elegans hypothetical protein y73c8b.2, caeel-Y73C8B.3Caenorhabditis elegans hypothetical protein.
Epoxide_hydrolase : caeel-C45B11.6Caenorhabditis elegans c45b11.6 protein, caeel-K02F3.6Caenorhabditis elegans K02F3.6, caeel-K07C5.5Caenorhabditis elegans cosmid K07C5 K07C5.5 gene ceeh-2, caeel-W01A11.1Caenorhabditis elegans similar to epoxide hydrolase.
FSH1 : caeel-C25G4.2Caenorhabditis elegans c25g4.2 protein.
Gliotactin : caeel-f55d10.3Caenorhabditis elegans F55D10.3 GLIoTactin (Drosophila neuroligin-like) homolog glit-1.
Hormone-sensitive_lipase_like : caeel-C46C11.1Caenorhabditis elegans C46C11.1.
LIDHydrolase : caeel-F11C1.4Caenorhabditis elegans f11c1.4 protein, caeel-F26A3.1Caenorhabditis elegans f26a3.1 protein.
Lipase_2 : caeel-C04B4.3Caenorhabditis elegans c04b4.3 protein, caeel-C09E8.2Caenorhabditis elegans c09e8.2 protein, caeel-F10F2.3Caenorhabditis elegans f10f2.3 protein, caeel-F14E5.5Caenorhabditis elegans f14e5.5 protein, caeel-F31F6.7Caenorhabditis elegans f31f6.7 protein, caeel-F45E6.4Caenorhabditis elegans f45e6.4 protein, caeel-F58G1.5Caenorhabditis elegans f58g1.5 protein, caeel-K12B6.3Caenorhabditis elegans k12b6.3 protein, caeel-T01C3.4Caenorhabditis elegans t01c3.4 protein, caeel-T12A7.4Caenorhabditis elegans t12a7.4 protein, caeel-Y38E10A.7Caenorhabditis elegans y38e10a.7 protein, caeel-ZK617.2Caenorhabditis elegans zk617.2 protein.
Lipase_3 : caeel-B0035.13Caenorhabditis elegans putative 32.6 kda lipase b0035.13 in chromosome IV precursor, caeel-C39B5.5Caenorhabditis elegans c39b5.5 protein, caeel-C40H1.7Caenorhabditis elegans c40h1.7 protein, caeel-F25A2.1Caenorhabditis elegans f25a2.1 protein, caeel-F28H7.3Caenorhabditis elegans f28h7.3 protein, caeel-F42G9.6Caenorhabditis elegans F42G9.6 protein, caeel-F46G10.4Caenorhabditis elegans f46g10.4 protein, caeel-H41C03.2Caenorhabditis elegans hypothetical 34.4 kda protein, caeel-K03H6.2Caenorhabditis elegans k03h6.2 protein, caeel-K08B12.1Caenorhabditis elegans similar to lipases, caeel-q4r165Caenorhabditis elegans hypothetical protein Y54G2A.45, caeel-q7yx60Caenorhabditis elegans hypothetical protein C40H1.9, caeel-q7yx61Caenorhabditis elegans hypothetical protein C40H1.8, caeel-q336k8Caenorhabditis elegans hypothetical protein F58B6.1, caeel-T08B1.4Caenorhabditis elegans t08b1.4 Lipase_3 domain-containing protein, caeel-T10B5.7Caenorhabditis elegans hypothetical 33.8 kda protein, caeel-T21H3.1Caenorhabditis elegans t21h3.1 protein, caeel-Y46H3A.4Caenorhabditis elegans hypothetical 41.7 kda protein, caeel-Y49E10.16Caenorhabditis elegans y49e10.16 protein, caeel-Y49E10.18Caenorhabditis elegans y49e10.18 protein, caeel-Y49E10.25Caenorhabditis elegans y49e10.25 protein, caeel-Y51H4A.5Caenorhabditis elegans y51h4a.5 protein, caeel-Y110A7A.7Caenorhabditis elegans y110a7a.7 protein, caeel-ZK262.2Caenorhabditis elegans zk262.2 protein, caeel-ZK262.3Caenorhabditis elegans zk262.3 protein.
LYsophospholipase_carboxylesterase : caeel-K04G2.5Caenorhabditis elegans K04G2.5 similar to lysophospholipases.
Ndr_family : caeel-Y48G10A.3Caenorhabditis elegans y48g10a.3 protein, caeel-ydj1Caenorhabditis elegans hypothetical 35.6 kda protein zk1073.1 in chromosome x.
Neuroligin : caeel-NLGN1Caenorhabditis elegans Neuroligin C40C9.5a gene Y12A6A.a.
NLS3-Tex30 : caeel-q22992Caenorhabditis elegans Protein F54D11.2 sumv-2.
OtherNon-catalytic_C : caeel-Y75b8.3Caenorhabditis elegans cosmid Y75B8A, complete sequence.
PAF-Acetylhydrolase : caeel-pafaCaenorhabditis elegans platelet-activating factor acetylhydrolase homolog (EC 3.1.1.47), caeel-W03G9.6Caenorhabditis elegans 1-alkyl-2-acetylglycerophosphocholine esterase (paf-1).
Palmitoyl-protein_thioesterase : caeel-F44C4.5Caenorhabditis elegans similar to palmitoyl-protein thioesterase precursor. ncbi gi: 1226321 PPT1.
PC-sterol_acyltransferase : caeel-M05B5.4Caenorhabditis elegans m05b5.4 protein.
PGAP1 : caeel-T19B10.8Caenorhabditis elegans t19b10.8 protein.
PMH_Peptidase_S9 : caeel-F01F1.5Caenorhabditis elegans similar to acylaminoacyl-peptidase.
PPase_methylesterase_euk : caeel-ppme1Caenorhabditis elegans Probable protein phosphatase methylesterase 1 42.9 kda protein b0464.7 in chromosome III.
Prolylcarboxypeptidase : caeel-C26B9.5Caenorhabditis elegans similar to k12h4.7 and human lysosomal pro-x carboxypeptidase, caeel-F19C7.2Caenorhabditis elegans similar to human lysosomal pro-x carboxypeptidase, caeel-F19C7.4Caenorhabditis elegans similar to human lysosomal pro-x carboxypeptidase, caeel-O02252.1Caenorhabditis elegans f23b2.11 protein, caeel-O02252.2Caenorhabditis elegans f23b2.11 protein, caeel-G5EFJ8.1Caenorhabditis elegans f23b2.12 protein, caeel-G5EFJ8.2Caenorhabditis elegans f23b2.12 protein, caeel-PCP5Caenorhabditis elegans hypothetical 56.9 kda protein zk688.6 in chromosome III, caeel-q9grv9.1Caenorhabditis elegans y116f11b.3 protein, caeel-q9grv9.2Caenorhabditis elegans y116f11b.3 protein, caeel-ym9iCaenorhabditis elegans putative serine protease f56f10.1 precursor (EC 3.4.-.-), caeel-ym67Caenorhabditis elegans hypothetical 65.3 kda protein k12h4.7 in chromosome III, caeel-yog1Caenorhabditis elegans hypothetical serine protease 59.2 kda protein zk112.1 in chromosome III.
Prolyl_oligopeptidase_S9 : caeel-f44b9.1Caenorhabditis elegans cosmid F44B9.
Thioesterase : caeel-C41A3.1Caenorhabditis elegans hypothetical protein, caeel-F32H2.5Caenorhabditis elegans f32h2.5 protein

Molecular evidence		Database
No mutation No structure No kinetic No Substrate No inhibitor		1 Genbank : AF099925 1 UniProt : Q9TZ58 1 Interpro : Q9TZ58 1 Pfam : Q9TZ58 1 PIRSF : Q9TZ58 1 SUPERFAM : Q9TZ58 1 WormBase : K01A2.5 1 WormBase Cosmid : K01A2

Sequence

Peptide

Graphical view for this peptide sequence: caeel-K01A2.5
Colored MSA for Valacyclovir-hydrolase (raw)
MTQSDYIESSEHIKDTQIGYCKYGHGPNYILAICGAVGCYKKDWPLKLLS HFPPDQVTIVGIDPPGYGTSRPPERKQEVQRCMKDSEYCLGLMETLKLEP FTVMGWSEGARTTVHVAAKGKEKVNRMIVMAGATKVNHLGAMAFKGMRET NHWLAAGRQPYLDHYSPETLRTQWAALCDVVDQVHSFCGGRFPCDLVLPQ VKCPTLVMNGGLDRFCGDPNVCFIPVLKSLAKVEIHAQGGHDFYLKYPKW FSGKVLEFLKSTEKK
Legend This sequence has been compared to family alignement (MSA)
red => minority aminoacid
blue => majority aminoacid
color intensity => conservation rate
title => sequence position(MSA position)aminoacid rate
Catalytic site
Catalytic site in the MSA
MTQSDYIESSEHIKDTQIGYCKYGHGPNYILAICGAVGCYKKDWPLKLLS
HFPPDQVTIVGIDPPGYGTSRPPERKQEVQRCMKDSEYCLGLMETLKLEP
FTVMGWSEGARTTVHVAAKGKEKVNRMIVMAGATKVNHLGAMAFKGMRET
NHWLAAGRQPYLDHYSPETLRTQWAALCDVVDQVHSFCGGRFPCDLVLPQ
VKCPTLVMNGGLDRFCGDPNVCFIPVLKSLAKVEIHAQGGHDFYLKYPKW
FSGKVLEFLKSTEKK

References

Title:

CEGSC

Ref:

282

PubMed

Title:

Wilson R, Ainscough R, Anderson K, Baynes C, Berks M, Bonfield J, Burton J, Connell M, Copsey T and et al. <1 more author(s)>

Ref:

368

PubMed

Other Papers

Send your questions or comments to :Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.

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