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caeel-zc376.2

Caenorhabditis elegans carboxylesterase ZC376_2 CEST-2.2

Comment

CEST-2.2 mainly localizes in the intestine and may stimulate the survival of mitochondrial deficient animalscest-2.2. In overexpressing animals CEST-2.2 stimulates lipid metabolism and fatty acid beta-oxidation, thereby enhancing mitochondrial respiratory capacity through complex II and LET-721\/ETFDH. (Piazzesi et al 2022)

Relationship

Family : Carb_B_Nematoda

Block : C

Position in NCBI Life Tree : Caenorhabditis elegans

Molecular evidence

No mutation

No structure

No kinetic

No disease

No substrate

No inhibitor

Database

Sequence

Peptide

MFFRFFILWA ILQNVRSTKV KLSTGTIEGR TLTASYSPLG NQTGIVFFGV PYVEPPVGNL RFRKPRPPKP WDGVLEAKEY KAACMSDQKK TYKNGVGGPV SEDCLYANVF TNQYCLEHKN CSVMLTIHGG RFVIESASAY DPEIIINNFV GQGRNIVVVT FNYRLGLFGL GMLNGDNQDT NFGLYGLKNL EIFSLLPDIL EVVRWTRKEI KNFGGDKDRI TMQGHSAGAV FTAAFSTSPL SKGLIHQQII MSASMSNLSK KSNVKELTVV ARIVGCLPDE HGFPKLSNVE VEKVLEKKAY TCLRSKSAQQ ILDAQLYMLR NTTYYIGQGH IDGIYQVDYP DNLYATNSIY PINTMIGTTT AELMDSRYIV DPKNTGKKEI LLQNLCEHIG YELYKEPEEF SQKCRNFYKN GEDAKSLGDD MEFYYGAIQL ANVHSSKDTN VFVYSFDYKE AGNAYKKYDK SLSPKHGEDF AYAFGTNRGN FSTKDYVIEY IYSGMFADFV NFGDPSPLED QEWAQYTPEK REYFLIDFDK NFTMPGMKDH YYPKALEFWS TCGSKSFKEH FSPSVDIFII GNLLNPIMSH LNHNETGPDK TFEQFDKLYN EREEFLKLLK AVRKLEIQKK MWRGRSSKDL MLKELVDLEK INEEEQETGA NFLLIIFGGT LLGGILYVSI SHFCLHHRSR DGYQLLK

References

Title : CEST-2.2 overexpression alters lipid metabolism and extends longevity of mitochondrial mutants - Piazzesi_2022_EMBO.Rep__e52606
Author(s) : Piazzesi A , Wang Y , Jackson J , Wischhof L , Zeisler-Diehl V , Scifo E , Oganezova I , Hoffmann T , Gomez Martin P , Bertan F , Wrobel CJJ , Schroeder FC , Ehninger D , Handler K , Schultze JL , Schreiber L , van Echten-Deckert G , Nicotera P , Bano D
Ref : EMBO Rep , :e52606 , 2022
Abstract : Piazzesi_2022_EMBO.Rep__e52606
ESTHER : Piazzesi_2022_EMBO.Rep__e52606
PubMedSearch : Piazzesi_2022_EMBO.Rep__e52606
PubMedID: 35297148
Gene_locus related to this paper: caeel-zc376.2

Title : Genome sequence of the nematode C. elegans: a platform for investigating biology. The C. elegans Sequencing Consortium - CEGSC_1998_Science_282_2012
Author(s) : CEGSC
Ref : Science , 282 :2012 , 1998
Abstract : CEGSC_1998_Science_282_2012
ESTHER : CEGSC_1998_Science_282_2012
PubMedSearch : CEGSC_1998_Science_282_2012
PubMedID: 9851916
Gene_locus related to this paper: caeel-1llip , caeel-ACHE1 , caeel-ACHE2 , caeel-ACHE3 , caeel-ACHE4 , caeel-b0238.1 , caeel-b0238.2 , caeel-b0238.7 , caeel-c01b10.4 , caeel-c01b10.10 , caeel-C04B4.3 , caeel-c08h9.1 , caeel-C09D4.4 , caeel-C09E8.2 , caeel-c17h12.4 , caeel-c23h4.2 , caeel-c23h4.3 , caeel-c23h4.7 , caeel-C25A1.12 , caeel-C25G4.2 , caeel-C26B9.5 , caeel-C27C12.7 , caeel-C31H5.1 , caeel-C31H5.6 , caeel-C37H5.2 , caeel-C37H5.3 , caeel-C39B5.5 , caeel-C40H1.7 , caeel-C41A3.1 , caeel-c42d4.2 , caeel-C45B11.6 , caeel-C46C11.1 , caeel-C50B6.9 , caeel-C52A10.1 , caeel-C54G4.7 , caeel-D1022.3 , caeel-D1022.4 , caeel-D2024.2 , caeel-E01G6.3 , caeel-ester , caeel-F01D5.7 , caeel-F01D5.8 , caeel-F01F1.5 , caeel-F01G10.7 , caeel-F10D2.10 , caeel-F10F2.3 , caeel-F11C1.4 , caeel-f13d12.6 , caeel-F14E5.5 , caeel-f15a8.6 , caeel-f16f9.4 , caeel-F19C7.2 , caeel-F19C7.4 , caeel-O02252.1 , caeel-O02252.2 , caeel-G5EFJ8.1 , caeel-G5EFJ8.2 , caeel-F25A2.1 , caeel-F26A3.1 , caeel-f27c8.6 , caeel-F28H7.3 , caeel-F31F6.7 , caeel-f32a5.3 , caeel-F32B4.6 , caeel-F32H2.5 , caeel-F35H12.5 , caeel-f41c3.5 , caeel-F42G9.6 , caeel-f44b9.1 , caeel-F44C4.5 , caeel-F45E6.4 , caeel-F46B6.8 , caeel-F46G10.4 , caeel-F54F3.3 , caeel-f55d10.3 , caeel-f55f3.c , caeel-f56c11.6 , caeel-F58G1.5 , caeel-ges1e , caeel-H41C03.2 , caeel-K01A2.5 , caeel-K02F2.1 , caeel-K02F3.6 , caeel-K03H6.2 , caeel-K04A8.5 , caeel-K04G2.2 , caeel-K04G2.5 , caeel-K05B2.4 , caeel-K07C5.5 , caeel-k07c11.4 , caeel-K08B12.1 , caeel-K08D9.4 , caeel-k10b2.2 , caeel-K10C2.1.1 , caeel-K10C2.1.2 , caeel-K10C2.1.3 , caeel-K10C2.1.4 , caeel-k11g9.1 , caeel-k11g9.2 , caeel-K12B6.3 , caeel-M05B5.4 , caeel-pafa , caeel-PCP5 , caeel-ppme1 , caeel-q4r165 , caeel-q5fc17 , caeel-q7m3k8 , caeel-q7yx60 , caeel-q7yx61 , caeel-q9tzh8 , caeel-q9tzh9 , caeel-q336k8 , caeel-q17846 , caeel-q22750 , caeel-q22992 , caeel-R05D7.4 , caeel-R11E3.8 , caeel-R11G11.14 , caeel-T01C3.4 , caeel-t02b5.1 , caeel-t02b5.3 , caeel-T05E7.1 , caeel-T07H6.1 , caeel-T08B1.4 , caeel-t09b9.1 , caeel-T10B5.7 , caeel-T12A7.4 , caeel-T19B10.8 , caeel-T21H3.1 , caeel-t22d1.11 , caeel-T23F1.7 , caeel-T23F4.3 , caeel-t28c12.4 , caeel-tmco4 , caeel-W01A11.1 , caeel-W03D8.8 , caeel-W03G9.6 , caeel-NLGN1 , caeel-Y16B4A.2 , caeel-Y32F6A.5 , caeel-Y38E10A.7 , caeel-Y40D12A.2 , caeel-Y43F8A.3 , caeel-Y46H3A.4 , caeel-Y48G10A.1 , caeel-Y48G10A.3 , caeel-Y49E10.16 , caeel-Y49E10.18 , caeel-Y49E10.25 , caeel-Y50E8A.7 , caeel-Y51H4A.5 , caeel-Y55F3AM.10 , caeel-Y57E12B.3 , caeel-Y60A3A.7 , caeel-Y71G12A.4 , caeel-Y71H2AM.K , caeel-Y73C8B.1 , caeel-Y73C8B.2 , caeel-Y73C8B.3 , caeel-Y75b8.3 , caeel-Y97E10AL.2 , caeel-Y110A7A.7 , caeel-q9grv9.1 , caeel-q9grv9.2 , caeel-ydj1 , caeel-ym9i , caeel-ym67 , caeel-yog1 , caeel-ypt1 , caeel-yyc5 , caeel-zc376.1 , caeel-zc376.2 , caeel-zc376.3 , caeel-ZK262.2 , caeel-ZK262.3 , caeel-ZK617.2 , caeel-f172a