Gene_locus Report for: canal-q59ng0 Candida albicans SC5314 cardiolipin-specific phospholipase
Comment
Other strains: Candida albicans P37037; SC5314; P78048; P94015; P57072 Relationship
(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.) cellular organisms: N E > Eukaryota: N E > Opisthokonta: N E > Fungi: N E > Dikarya: N E > Ascomycota: N E > saccharomyceta: N E > Saccharomycotina: N E > Saccharomycetes: N E > Saccharomycetales: N E > Debaryomycetaceae: N E > Candida/Lodderomyces clade: N E > Candida [Debaryomycetaceae]: N E > Candida albicans: N E > Candida albicans SC5314: N E 6_AlphaBeta_hydrolase :
canal-q5ams7 Candida albicans SC5314 hypothetical protein ,
canal-q59k70 Candida albicans SC5314 hypothetical protein ,
canal-q59s22 Candida albicans SC5314 potential vacuolar protein ,
canal-q59vf1 Candida albicans SC5314 potential esterase/lipase/thioesterase/phosphatase .
A85-EsteraseD-FGH :
canal-q59nl9 Candida albicans SC5314 hypothetical protein .
ABHD11-Acetyl_transferase :
canal-q5a0i7 Candida albicans SC5314 hypothetical protein ,
canal-q59we9 Candida albicans SC5314 hypothetical protein .
ABHD13-BEM46 :
canal-q5acl5 Candida albicans SC5314 hypothetical protein .
abh_upf0017 :
canal-q59u61 Candida albicans (strains WO-1; SC5314) (Yeast) hypothetical protein .
Acidic_Lipase :
canal-q5ad17 Candida albicans, Candida tropicalis, Candida dubliniensis (Yeast) hypothetical protein tgl1 ,
canal-q5akz5 Candida albicans, Candida dubliniensis (Yeast) hypothetical protein tgl99 .
Carboxypeptidase_S10 :
canal-q5aa97 Candida albicans PRC3 CPY2 potential serine carboxypeptidase ,
canal-q59nw6 Candida albicans (Yeast), Candida dubliniensis, potential serine carboxypeptidase .
CGI-58_ABHD5_ABHD4 :
canal-q59y42 Candida albicans SC5314 hypothetical protein ,
canal-q59y97 Candida albicans (strains SC5314; WO-1) (Yeast)hypothetical protein .
Dienelactone_hydrolase :
canal-q5ai87 Candida albicans SC5314 hypothetical protein ,
canal-q5amn4 Candida albicans SC5314 hypothetical protein ,
canal-q5amn7 Candida albicans SC5314 hypothetical protein .
DPP4N_Peptidase_S9 :
canal-q5ag57 Candida albicans, Candida dubliniensis, hypothetical protein dap2 ,
canal-q59m48 Candida albicans, Candida dubliniensis, potential alpha-factor pheromone maturation protease .
Duf_676 :
canal-q5ak29 Candida albicans SC5314 hypothetical protein ,
canal-q5ams2 Candida albicans SC5314 hypothetical protein ,
canal-q59kl3 Candida albicans potential lipid particle serine esterase ,
canal-q59ln6 Candida albicans SC5314 hypothetical protein .
Duf_1749 :
canal-q5ajt3 Candida albicans (Yeast). hypothetical protein .
FSH1 :
canal-q5adx4 Candida albicans; Candida dubliniensis hypothetical protein ,
canal-q5akr2 Candida albicans; Candida dubliniensis hypothetical protein .
Homoserine_transacetylase :
canal-q5a948 Candida albicans SC5314 potential homoserine o-trans-acetylase ,
canal-q59tt5 Candida albicans SC5314 potential serine o-trans-acetylase .
Lipase_3 :
canal-q5amg8 Candida albicans SC5314 potential triglyceride lipase ,
canal-q59xq6 Candida albicans SC5314 potential secreted triacylglycerol lipase. Autophagy-related protein 15 .
LYsophospholipase_carboxylesterase :
canal-apth1 Candida albicans SC5314 likely phospholipase/carboxylesterase .
Monoglyceridelipase_lysophospholip :
canal-q5apu4 Candida albicans, Candida dubliniensis hypothetical protein yju3 .
Palmitoyl-protein_thioesterase :
canal-q5a6l4 Candida albicans SC5314 hypothetical protein ppt2 .
PC-sterol_acyltransferase :
canal-q5abf2 Candida albicans SC5314 hypothetical protein lro1 .
PGAP1 :
canal-q5ai09 Candida albicans (strains SC5314; WO-1) hypothetical protein tgl2 ,
canal-q59vp0 Candida albicans (strains SC5314; WO-1) hypothetical protein bst1 .
PPase_methylesterase_euk :
canal-ppme1 Candida albicans (and strain WO-1)Candida dubliniensis (strain CD36 / CBS 7987 / NCPF 3949 / NRR Y-17841) protein phosphatase methylesterase 1 (EC 3.1.1.-) (pme-1) .
Proline_iminopeptidase :
canal-q5a2i9 Candida albicans (Yeast) hypothetical protein pna1 Molecular evidence
Database
No mutation No structure No kinetic No Substrate No inhibitor
Sequence
Graphical view for this peptide sequence: canal-q59ng0 Colored MSA for CGI-58_ABHD5_ABHD4 (raw)
MLILKRLLTTSCTLLDTSPKNYYKIIAPSTFETKKCESYNEKHSSTTTEI
TATSTATVADTVEDELTITHKTKRKFISTYKRSTHPTSVPLSKIFSNNFP
LSINESFEDYKYRNNPLKFQHDLLSILPFYPTPDLQVKTKEGRSSEVLKV
EIDDKGNYINEFVIYPENYNPQVMPDDEYHHLIMVHGYGAGLGFFLKNFD
EISNFQPNNTQNNKYIVHAIDLLGYGCSSRPNFYPQNLDQVENWFHDSFI
TWLQKRNIPSDKTIVMAHSMGAYLMATLAINRNLKFCSKLLMVSPGAIIK
HQTPVQVPRYFVKLWERNISPFTIVRKLGPLGSKIVSGWSSRRFDKLTRQ
EKKLLHKYSYGIFQSKGSGEYMLNYLLAPGADARHPLVDRGIDRITCDVS
WWYGKEDWMDKKGGQICSAIINNKGEFKSDVKIIEDSGHHIYLDNIKKFN
SMVLEEMNQLINK
Legend
This sequence has been compared to family alignement (MSA) red => minority aminoacid blue => majority aminoacid color intensity => conservation rate title => sequence position(MSA position)aminoacid rate Catalytic site Catalytic site in the MSA
M L I L K R L L T T S C T L L D T S P K N Y Y K I I A P S T F E T K K C E S Y N E K H S S T T T E I T A T S T A T V A D T V E D E L T I T H K T K R K F I S T Y K R S T H P T S V P L S K I F S N N F P L S I N E S F E D Y K Y R N N P L K F Q H D L L S I L P F Y P T P D L Q V K T K E G R S S E V L K V E I D D K G N Y I N E F V I Y P E N Y N P Q V M P D D E Y H H L I M V H G Y G A G L G F F L K N F D E I S N F Q P N N T Q N N K Y I V H A I D L L G Y G C S S R P N F Y P Q N L D Q V E N W F H D S F I T W L Q K R N I P S D K T I V M A H S M G A Y L M A T L A I N R N L K F C S K L L M V S P G A I I K H Q T P V Q V P R Y F V K L W E R N I S P F T I V R K L G P L G S K I V S G W S S R R F D K L T R Q E K K L L H K Y S Y G I F Q S K G S G E Y M L N Y L L A P G A D A R H P L V D R G I D R I T C D V S W W Y G K E D W M D K K G G Q I C S A I I N N K G E F K S D V K I I E D S G H H I Y L D N I K K F N S M V L E E M N Q L I N K
Reference
Title: The diploid genome sequence of Candida albicansJones T , Federspiel NA , Chibana H , Dungan J , Kalman S , Magee BB , Newport G , Thorstenson YR , Agabian N and Scherer S <2 more author(s)> Jones T , Federspiel NA , Chibana H , Dungan J , Kalman S , Magee BB , Newport G , Thorstenson YR , Agabian N , Magee PT , Davis RW , Scherer S (- 2) Ref: Proc Natl Acad Sci U S A, 101 :7329, 2004 : PubMed Abstract ESTHER: Jones_2004_Proc.Natl.Acad.Sci.U.S.A_101_7329 PubMedSearch: Jones 2004 Proc.Natl.Acad.Sci.U.S.A 101 7329 PubMedID: 15123810 Gene_locus related to this paper: canal-apth1 ,
canal-ATG15 ,
canal-bna7 ,
canal-c4yl13 ,
canal-cbpy ,
canal-LIP1 ,
canal-LIP2 ,
canal-LIP3 ,
canal-LIP4 ,
canal-LIP5 ,
canal-LIP6 ,
canal-LIP7 ,
canal-LIP8 ,
canal-LIP9 ,
canal-LIP10 ,
canal-ppme1 ,
canal-q5a0c9 ,
canal-q5a0i7 ,
canal-q5a2i9 ,
canal-q5a2u7 ,
canal-q5a6l4 ,
canal-q5a042 ,
canal-q5a948 ,
canal-q5aa97 ,
canal-q5abf2 ,
canal-q5acl5 ,
canal-q5ad17 ,
canal-q5adx4 ,
canal-q5ady2 ,
canal-q5aeu3 ,
canal-q5afp8 ,
canal-q5ag57 ,
canal-q5ah37 ,
canal-q5ai09 ,
canal-q5ai12 ,
canal-q5ai87 ,
canal-q5ajt3 ,
canal-q5ak09 ,
canal-q5ak29 ,
canal-q5ak96 ,
canal-q5akr2 ,
canal-q5akz5 ,
canal-q5amg8 ,
canal-q5amn4 ,
canal-q5amn7 ,
canal-q5ams2 ,
canal-q5ams7 ,
canal-q5apu4 ,
canal-q59k70 ,
canal-q59kl3 ,
canal-q59l46 ,
canal-q59ln6 ,
canal-q59m48 ,
canal-q59ng0 ,
canal-q59nl9 ,
canal-q59nw6 ,
canal-q59nx4 ,
canal-q59nx8 ,
canal-q59s22 ,
canal-q59tt5 ,
canal-q59u61 ,
canal-q59u64 ,
canal-q59vf1 ,
canal-q59vp0 ,
canal-q59we9 ,
canal-q59xq6 ,
canal-q59y42 ,
canal-q59y97 ,
canaw-c4yrr3 ,
canal-hda1 Abstract
We present the diploid genome sequence of the fungal pathogen Candida albicans. Because C. albicans has no known haploid or homozygous form, sequencing was performed as a whole-genome shotgun of the heterozygous diploid genome in strain SC5314, a clinical isolate that is the parent of strains widely used for molecular analysis. We developed computational methods to assemble a diploid genome sequence in good agreement with available physical mapping data. We provide a whole-genome description of heterozygosity in the organism. Comparative genomic analyses provide important clues about the evolution of the species and its mechanisms of pathogenesis.
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