Gene_locus Report for: canal-q59s22 Candida albicans SC5314 potential vacuolar protein
Comment
Only c-term Pfam Abhydrolase_1, n-term DUF2417. Other strains: Candida albicans SC5314 P78048 P94015 P76067 P57072 Ca529L P57055 P34048; WO-1 Relationship
(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.) cellular organisms: N E > Eukaryota: N E > Opisthokonta: N E > Fungi: N E > Dikarya: N E > Ascomycota: N E > saccharomyceta: N E > Saccharomycotina: N E > Saccharomycetes: N E > Saccharomycetales: N E > Debaryomycetaceae: N E > Candida/Lodderomyces clade: N E > Candida [Debaryomycetaceae]: N E > Candida albicans: N E > Candida albicans SC5314: N E 6_AlphaBeta_hydrolase :
canal-q5ams7 Candida albicans SC5314 hypothetical protein ,
canal-q59k70 Candida albicans SC5314 hypothetical protein ,
canal-q59vf1 Candida albicans SC5314 potential esterase/lipase/thioesterase/phosphatase .
A85-EsteraseD-FGH :
canal-q59nl9 Candida albicans SC5314 hypothetical protein .
ABHD11-Acetyl_transferase :
canal-q5a0i7 Candida albicans SC5314 hypothetical protein ,
canal-q59we9 Candida albicans SC5314 hypothetical protein .
ABHD13-BEM46 :
canal-q5acl5 Candida albicans SC5314 hypothetical protein .
abh_upf0017 :
canal-q59u61 Candida albicans (strains WO-1; SC5314) (Yeast) hypothetical protein .
Acidic_Lipase :
canal-q5ad17 Candida albicans, Candida tropicalis, Candida dubliniensis (Yeast) hypothetical protein tgl1 ,
canal-q5akz5 Candida albicans, Candida dubliniensis (Yeast) hypothetical protein tgl99 .
Carboxypeptidase_S10 :
canal-q5aa97 Candida albicans PRC3 CPY2 potential serine carboxypeptidase ,
canal-q59nw6 Candida albicans (Yeast), Candida dubliniensis, potential serine carboxypeptidase .
CGI-58_ABHD5_ABHD4 :
canal-q59ng0 Candida albicans SC5314 cardiolipin-specific phospholipase ,
canal-q59y42 Candida albicans SC5314 hypothetical protein ,
canal-q59y97 Candida albicans (strains SC5314; WO-1) (Yeast)hypothetical protein .
Dienelactone_hydrolase :
canal-q5ai87 Candida albicans SC5314 hypothetical protein ,
canal-q5amn4 Candida albicans SC5314 hypothetical protein ,
canal-q5amn7 Candida albicans SC5314 hypothetical protein .
DPP4N_Peptidase_S9 :
canal-q5ag57 Candida albicans, Candida dubliniensis, hypothetical protein dap2 ,
canal-q59m48 Candida albicans, Candida dubliniensis, potential alpha-factor pheromone maturation protease .
Duf_676 :
canal-q5ak29 Candida albicans SC5314 hypothetical protein ,
canal-q5ams2 Candida albicans SC5314 hypothetical protein ,
canal-q59kl3 Candida albicans potential lipid particle serine esterase ,
canal-q59ln6 Candida albicans SC5314 hypothetical protein .
FSH1 :
canal-q5adx4 Candida albicans; Candida dubliniensis hypothetical protein ,
canal-q5akr2 Candida albicans; Candida dubliniensis hypothetical protein .
Fusarinine_C_esterase_sidJ :
canal-q5ajt3 Candida albicans (Yeast). hypothetical protein .
Homoserine_transacetylase :
canal-q5a948 Candida albicans SC5314 potential homoserine o-trans-acetylase ,
canal-q59tt5 Candida albicans SC5314 potential serine o-trans-acetylase .
Lipase_3 :
canal-q5amg8 Candida albicans SC5314 potential triglyceride lipase ,
canal-q59xq6 Candida albicans SC5314 potential secreted triacylglycerol lipase. Autophagy-related protein 15 .
LYsophospholipase_carboxylesterase :
canal-apth1 Candida albicans SC5314 likely phospholipase/carboxylesterase .
Monoglyceridelipase_lysophospholip :
canal-q5apu4 Candida albicans, Candida dubliniensis hypothetical protein yju3 .
Palmitoyl-protein_thioesterase :
canal-q5a6l4 Candida albicans SC5314 hypothetical protein ppt2 .
PC-sterol_acyltransferase :
canal-q5abf2 Candida albicans SC5314 hypothetical protein lro1 .
PGAP1 :
canal-q5ai09 Candida albicans (strains SC5314; WO-1) hypothetical protein tgl2 ,
canal-q59vp0 Candida albicans (strains SC5314; WO-1) hypothetical protein bst1 .
PPase_methylesterase_euk :
canal-ppme1 Candida albicans (and strain WO-1)Candida dubliniensis (strain CD36 / CBS 7987 / NCPF 3949 / NRR Y-17841) protein phosphatase methylesterase 1 (EC 3.1.1.-) (pme-1) .
Proline_iminopeptidase :
canal-q5a2i9 Candida albicans (Yeast) hypothetical protein pna1 Molecular evidence
Database
No mutation No structure No kinetic No Substrate No inhibitor
Sequence
Graphical view for this peptide sequence: canal-q59s22 Colored MSA for 6_AlphaBeta_hydrolase (raw)
NQFRVHLACFGDVHGKSDQPIVLVEGGQSTSSEAFQEWIEELHHLNKVER
YCIWDRPGYGFSDSAPPPESLGIVTEYLMEALRKEKIEGPFSVVGFDIGG
LYARMFASRNRAKIQSILFVDSWSPDLLKKWPFSGSGRKNESTKVFKKSL
EVMDNITGFKLWLRGFVSPLGVLPNLHWFLHPMRFSSKSRIFGRDMVYSS
KYIRARCQEQLVSGILSYNEIMDADINDLNVGVISSDFMIKKSLNWGKWQ
NEISKLSRKTSEWVIAENSDHFIWNSPKGRKELQQLLLRLIGEQEYLK
Legend
This sequence has been compared to family alignement (MSA) red => minority aminoacid blue => majority aminoacid color intensity => conservation rate title => sequence position(MSA position)aminoacid rate Catalytic site Catalytic site in the MSA
N Q F R V H L A C F G D V H G K S D Q P I V L V E G G Q S T S S E A F Q E W I E E L H H L N K V E R Y C I W D R P G Y G F S D S A P P P E S L G I V T E Y L M E A L R K E K I E G P F S V V G F D I G G L Y A R M F A S R N R A K I Q S I L F V D S W S P D L L K K W P F S G S G R K N E S T K V F K K S L E V M D N I T G F K L W L R G F V S P L G V L P N L H W F L H P M R F S S K S R I F G R D M V Y S S K Y I R A R C Q E Q L V S G I L S Y N E I M D A D I N D L N V G V I S S D F M I K K S L N W G K W Q N E I S K L S R K T S E W V I A E N S D H F I W N S P K G R K E L Q Q L L L R L I G E Q E Y L K
Reference
Title: The diploid genome sequence of Candida albicansJones T , Federspiel NA , Chibana H , Dungan J , Kalman S , Magee BB , Newport G , Thorstenson YR , Agabian N and Scherer S <2 more author(s)> Jones T , Federspiel NA , Chibana H , Dungan J , Kalman S , Magee BB , Newport G , Thorstenson YR , Agabian N , Magee PT , Davis RW , Scherer S (- 2) Ref: Proc Natl Acad Sci U S A, 101 :7329, 2004 : PubMed Abstract ESTHER: Jones_2004_Proc.Natl.Acad.Sci.U.S.A_101_7329 PubMedSearch: Jones 2004 Proc.Natl.Acad.Sci.U.S.A 101 7329 PubMedID: 15123810 Gene_locus related to this paper: canal-apth1 ,
canal-ATG15 ,
canal-bna7 ,
canal-c4yl13 ,
canal-cbpy ,
canal-LIP1 ,
canal-LIP2 ,
canal-LIP3 ,
canal-LIP4 ,
canal-LIP5 ,
canal-LIP6 ,
canal-LIP7 ,
canal-LIP8 ,
canal-LIP9 ,
canal-LIP10 ,
canal-ppme1 ,
canal-q5a0c9 ,
canal-q5a0i7 ,
canal-q5a2i9 ,
canal-q5a2u7 ,
canal-q5a6l4 ,
canal-q5a042 ,
canal-q5a948 ,
canal-q5aa97 ,
canal-q5abf2 ,
canal-q5acl5 ,
canal-q5ad17 ,
canal-q5adx4 ,
canal-q5ady2 ,
canal-q5aeu3 ,
canal-q5afp8 ,
canal-q5ag57 ,
canal-q5ah37 ,
canal-q5ai09 ,
canal-q5ai12 ,
canal-q5ai87 ,
canal-q5ajt3 ,
canal-q5ak09 ,
canal-q5ak29 ,
canal-q5ak96 ,
canal-q5akr2 ,
canal-q5akz5 ,
canal-q5amg8 ,
canal-q5amn4 ,
canal-q5amn7 ,
canal-q5ams2 ,
canal-q5ams7 ,
canal-q5apu4 ,
canal-q59k70 ,
canal-q59kl3 ,
canal-q59l46 ,
canal-q59ln6 ,
canal-q59m48 ,
canal-q59ng0 ,
canal-q59nl9 ,
canal-q59nw6 ,
canal-q59nx4 ,
canal-q59nx8 ,
canal-q59s22 ,
canal-q59tt5 ,
canal-q59u61 ,
canal-q59u64 ,
canal-q59vf1 ,
canal-q59vp0 ,
canal-q59we9 ,
canal-q59xq6 ,
canal-q59y42 ,
canal-q59y97 ,
canaw-c4yrr3 ,
canal-hda1 Abstract
We present the diploid genome sequence of the fungal pathogen Candida albicans. Because C. albicans has no known haploid or homozygous form, sequencing was performed as a whole-genome shotgun of the heterozygous diploid genome in strain SC5314, a clinical isolate that is the parent of strains widely used for molecular analysis. We developed computational methods to assemble a diploid genome sequence in good agreement with available physical mapping data. We provide a whole-genome description of heterozygosity in the organism. Comparative genomic analyses provide important clues about the evolution of the species and its mechanisms of pathogenesis.
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