Gene_locus Report for: canal-q59u61 Candida albicans (strains WO-1; SC5314) (Yeast) hypothetical protein
Relationship
(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.) cellular organisms: N E > Eukaryota: N E > Opisthokonta: N E > Fungi: N E > Dikarya: N E > Ascomycota: N E > saccharomyceta: N E > Saccharomycotina: N E > Saccharomycetes: N E > Saccharomycetales: N E > Debaryomycetaceae: N E > Candida/Lodderomyces clade: N E > Candida [Debaryomycetaceae]: N E > Candida albicans: N E > Candida albicans SC5314: N E 6_AlphaBeta_hydrolase :
canal-q5ams7 Candida albicans SC5314 hypothetical protein ,
canal-q59k70 Candida albicans SC5314 hypothetical protein ,
canal-q59s22 Candida albicans SC5314 potential vacuolar protein ,
canal-q59vf1 Candida albicans SC5314 potential esterase/lipase/thioesterase/phosphatase .
A85-EsteraseD-FGH :
canal-q59nl9 Candida albicans SC5314 hypothetical protein .
ABHD11-Acetyl_transferase :
canal-q5a0i7 Candida albicans SC5314 hypothetical protein ,
canal-q59we9 Candida albicans SC5314 hypothetical protein .
ABHD13-BEM46 :
canal-q5acl5 Candida albicans SC5314 hypothetical protein .
Acidic_Lipase :
canal-q5ad17 Candida albicans, Candida tropicalis, Candida dubliniensis (Yeast) hypothetical protein tgl1 ,
canal-q5akz5 Candida albicans, Candida dubliniensis (Yeast) hypothetical protein tgl99 .
Carboxypeptidase_S10 :
canal-q5aa97 Candida albicans PRC3 CPY2 potential serine carboxypeptidase ,
canal-q59nw6 Candida albicans (Yeast), Candida dubliniensis, potential serine carboxypeptidase .
CGI-58_ABHD5_ABHD4 :
canal-q59ng0 Candida albicans SC5314 cardiolipin-specific phospholipase ,
canal-q59y42 Candida albicans SC5314 hypothetical protein ,
canal-q59y97 Candida albicans (strains SC5314; WO-1) (Yeast)hypothetical protein .
Dienelactone_hydrolase :
canal-q5ai87 Candida albicans SC5314 hypothetical protein ,
canal-q5amn4 Candida albicans SC5314 hypothetical protein ,
canal-q5amn7 Candida albicans SC5314 hypothetical protein .
DPP4N_Peptidase_S9 :
canal-q5ag57 Candida albicans, Candida dubliniensis, hypothetical protein dap2 ,
canal-q59m48 Candida albicans, Candida dubliniensis, potential alpha-factor pheromone maturation protease .
Duf_676 :
canal-q5ak29 Candida albicans SC5314 hypothetical protein ,
canal-q5ams2 Candida albicans SC5314 hypothetical protein ,
canal-q59kl3 Candida albicans potential lipid particle serine esterase ,
canal-q59ln6 Candida albicans SC5314 hypothetical protein .
FSH1 :
canal-q5adx4 Candida albicans; Candida dubliniensis hypothetical protein ,
canal-q5akr2 Candida albicans; Candida dubliniensis hypothetical protein .
Fusarinine_C_esterase_sidJ :
canal-q5ajt3 Candida albicans (Yeast). hypothetical protein .
Homoserine_transacetylase :
canal-q5a948 Candida albicans SC5314 potential homoserine o-trans-acetylase ,
canal-q59tt5 Candida albicans SC5314 potential serine o-trans-acetylase .
Lipase_3 :
canal-q5amg8 Candida albicans SC5314 potential triglyceride lipase ,
canal-q59xq6 Candida albicans SC5314 potential secreted triacylglycerol lipase. Autophagy-related protein 15 .
LYsophospholipase_carboxylesterase :
canal-apth1 Candida albicans SC5314 likely phospholipase/carboxylesterase .
Monoglyceridelipase_lysophospholip :
canal-q5apu4 Candida albicans, Candida dubliniensis hypothetical protein yju3 .
Palmitoyl-protein_thioesterase :
canal-q5a6l4 Candida albicans SC5314 hypothetical protein ppt2 .
PC-sterol_acyltransferase :
canal-q5abf2 Candida albicans SC5314 hypothetical protein lro1 .
PGAP1 :
canal-q5ai09 Candida albicans (strains SC5314; WO-1) hypothetical protein tgl2 ,
canal-q59vp0 Candida albicans (strains SC5314; WO-1) hypothetical protein bst1 .
PPase_methylesterase_euk :
canal-ppme1 Candida albicans (and strain WO-1)Candida dubliniensis (strain CD36 / CBS 7987 / NCPF 3949 / NRR Y-17841) protein phosphatase methylesterase 1 (EC 3.1.1.-) (pme-1) .
Proline_iminopeptidase :
canal-q5a2i9 Candida albicans (Yeast) hypothetical protein pna1 Warning: This entry is a compilation of different species or line or strain with more than 90% amino acid identity. You can
retrieve all strain data
(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.) Candida albicans WO-1:
N ,
E .
Molecular evidence
Database
No mutation No structure No kinetic No Substrate No inhibitor
Sequence
Graphical view for this peptide sequence: canal-q59u61 Colored MSA for abh_upf0017 (raw)
MSGFFVSRVESHFSKNPIKFKPRSNSSHEANNNTTSNLINKFKPKKTSKG
TDNELPNSIPEMIQTAIPEFSPKYSFFVNPLLSSGHTQTAYTALNKFENQ
HEVHYKREIITIENKPYTLPNGDQLYYDQWKGESTIALDYAVNSSLGPDL
NHEQYKPESQTRPLPPRTEFKNPNEDLISDDEKPLLIILHGLSGGSYEAY
LRAVIDKIIEPPFEFDAMVINSRGCANHTITSPQLYNGLWTNDVRYVINE
IVSKRWPQKRVFLMGFSLGAAILANYLGQEGAHASPQIKGSVAIGCPWDF
VDGSFQLRESVIGHYIYSPTMANNLLKLLNSHHILLANDLVKQYKEDPTR
NEIKFLKQFDNEFTAKMFGLNSADEYYRKASPIQRLLNVRVPMVILSSLD
DPVVGSRSLPYSEVNLNPYVSLITTSVGGHLGWFAINGDRWYVEPVCKLL
TVLNQYDADKESIVELPVDISETSWKYDRLVNGMLVDQ
Legend
This sequence has been compared to family alignement (MSA) red => minority aminoacid blue => majority aminoacid color intensity => conservation rate title => sequence position(MSA position)aminoacid rate Catalytic site Catalytic site in the MSA
M S G F F V S R V E S H F S K N P I K F K P R S N S S H E A N N N T T S N L I N K F K P K K T S K G T D N E L P N S I P E M I Q T A I P E F S P K Y S F F V N P L L S S G H T Q T A Y T A L N K F E N Q H E V H Y K R E I I T I E N K P Y T L P N G D Q L Y Y D Q W K G E S T I A L D Y A V N S S L G P D L N H E Q Y K P E S Q T R P L P P R T E F K N P N E D L I S D D E K P L L I I L H G L S G G S Y E A Y L R A V I D K I I E P P F E F D A M V I N S R G C A N H T I T S P Q L Y N G L W T N D V R Y V I N E I V S K R W P Q K R V F L M G F S L G A A I L A N Y L G Q E G A H A S P Q I K G S V A I G C P W D F V D G S F Q L R E S V I G H Y I Y S P T M A N N L L K L L N S H H I L L A N D L V K Q Y K E D P T R N E I K F L K Q F D N E F T A K M F G L N S A D E Y Y R K A S P I Q R L L N V R V P M V I L S S L D D P V V G S R S L P Y S E V N L N P Y V S L I T T S V G G H L G W F A I N G D R W Y V E P V C K L L T V L N Q Y D A D K E S I V E L P V D I S E T S W K Y D R L V N G M L V D Q
References
Title: Evolution of pathogenicity and sexual reproduction in eight Candida genomesButler G , Rasmussen MD , Lin MF , Santos MA , Sakthikumar S , Munro CA , Rheinbay E , Grabherr M , Forche A and Cuomo CA <41 more author(s)> Butler G , Rasmussen MD , Lin MF , Santos MA , Sakthikumar S , Munro CA , Rheinbay E , Grabherr M , Forche A , Reedy JL , Agrafioti I , Arnaud MB , Bates S , Brown AJ , Brunke S , Costanzo MC , Fitzpatrick DA , de Groot PW , Harris D , Hoyer LL , Hube B , Klis FM , Kodira C , Lennard N , Logue ME , Martin R , Neiman AM , Nikolaou E , Quail MA , Quinn J , Santos MC , Schmitzberger FF , Sherlock G , Shah P , Silverstein KA , Skrzypek MS , Soll D , Staggs R , Stansfield I , Stumpf MP , Sudbery PE , Srikantha T , Zeng Q , Berman J , Berriman M , Heitman J , Gow NA , Lorenz MC , Birren BW , Kellis M , Cuomo CA (- 41) Ref: Nature, 459 :657, 2009 : PubMed Abstract ESTHER: Butler_2009_Nature_459_657 PubMedSearch: Butler 2009 Nature 459 657 PubMedID: 19465905 Gene_locus related to this paper: canal-ATG15 ,
canal-bna7 ,
canal-c4yl13 ,
canal-LIP1 ,
canal-LIP2 ,
canal-LIP3 ,
canal-LIP4 ,
canal-LIP5 ,
canal-LIP6 ,
canal-LIP7 ,
canal-LIP8 ,
canal-LIP9 ,
canal-LIP10 ,
canal-ppme1 ,
canal-q5a0c9 ,
canal-q5a2i9 ,
canal-q5a042 ,
canal-q5ad17 ,
canal-q5aeu3 ,
canal-q5afp8 ,
canal-q5ag57 ,
canal-q5ai09 ,
canal-q5ai12 ,
canal-q5ajt3 ,
canal-q5akz5 ,
canal-q5apu4 ,
canal-q59l46 ,
canal-q59m48 ,
canal-q59nw6 ,
canal-q59u61 ,
canal-q59u64 ,
canal-q59vp0 ,
canal-q59y97 ,
canaw-c4ykb1 ,
canaw-c4yrn6 ,
canaw-c4yrn9 ,
canaw-c4yrr3 ,
canaw-c4yrv3 ,
canaw-c4ys26 ,
cantt-c5m3d7 ,
cantt-c5m3y5 ,
cantt-c5m4x0 ,
cantt-c5m5e8 ,
cantt-c5m5w2 ,
cantt-c5m8s7 ,
cantt-c5m9c2 ,
cantt-c5m465 ,
cantt-c5m751 ,
cantt-c5m793 ,
cantt-c5m893 ,
cantt-c5ma78 ,
cantt-c5mag0 ,
cantt-c5mbb8 ,
cantt-c5mc53 ,
cantt-c5md87 ,
cantt-c5mdy3 ,
cantt-c5mey7 ,
cantt-c5mfg0 ,
cantt-c5mfh8 ,
cantt-c5mg56 ,
cantt-c5mgj0 ,
cantt-c5mh75 ,
cantt-c5mh80 ,
cantt-c5mh89 ,
cantt-c5mhh0 ,
cantt-c5mhn5 ,
cantt-c5mij5 ,
cantt-c5min7 ,
clal4-c4xvt8 ,
clal4-c4xwy4 ,
clal4-c4xy03 ,
clal4-c4xyx9 ,
clal4-c4xzz1 ,
clal4-c4y3e1 ,
clal4-c4y4f2 ,
clal4-c4y4w8 ,
clal4-c4y5j4 ,
clal4-c4y5j9 ,
clal4-c4y7z7 ,
clal4-c4y8q1 ,
clal4-c4y035 ,
clal4-c4y481 ,
clal4-c4y538 ,
clal4-c4y898 ,
clal4-c4yas2 ,
clal4-c4yba6 ,
clal4-c4yba7 ,
clal4-c4yc85 ,
lodel-a5drz3 ,
lodel-a5ds97 ,
lodel-a5dsc0 ,
lodel-a5duu4 ,
lodel-a5duy7 ,
lodel-a5dv03 ,
lodel-a5dv46 ,
lodel-a5dw16 ,
lodel-a5dwv7 ,
lodel-a5dww6 ,
lodel-a5dxf3 ,
lodel-a5e0z5 ,
lodel-a5e1c1 ,
lodel-a5e1l4 ,
lodel-a5e1p3 ,
lodel-a5e2s1 ,
lodel-a5e2t8 ,
lodel-a5e2v2 ,
lodel-a5e4u8 ,
lodel-a5e5a9 ,
lodel-a5e5k1 ,
lodel-a5e5z7 ,
lodel-a5e6w1 ,
lodel-a5e028 ,
lodel-atg15 ,
lodel-kex1 ,
picgu-a5d9u2 ,
picgu-a5dav0 ,
picgu-a5dbk0 ,
picgu-a5dc45 ,
picgu-a5dc73 ,
picgu-a5dc74 ,
picgu-a5dc75 ,
picgu-a5ddt8 ,
picgu-a5dev7 ,
picgu-a5dh90 ,
picgu-a5dhe3 ,
picgu-a5di38 ,
picgu-a5dj06 ,
picgu-a5dkd8 ,
picgu-a5dle9 ,
picgu-a5dlj5 ,
picgu-a5dm19 ,
picgu-a5dn92 ,
picgu-a5dnr3 ,
picgu-a5dnt6 ,
picgu-a5dqu5 ,
picgu-a5dr14 ,
picgu-a5drl3 ,
picgu-atg15 ,
picgu-bna7 ,
picgu-a5d9q3 ,
picgu-a5dag9 ,
clal4-c4y5a2 ,
clal4-c4y0l0 ,
cantt-c5mcb1 ,
clal4-c4y8j2 ,
cantt-c5m494 ,
clals-a0a202gac7 ,
canal-hda1 ,
picgu-a5dks8 ,
lodel-a5drs6 ,
canpc-g8bbk1 ,
cantt-kex1 ,
clal4-kex1 ,
picgu-kex1 Abstract
Candida species are the most common cause of opportunistic fungal infection worldwide. Here we report the genome sequences of six Candida species and compare these and related pathogens and non-pathogens. There are significant expansions of cell wall, secreted and transporter gene families in pathogenic species, suggesting adaptations associated with virulence. Large genomic tracts are homozygous in three diploid species, possibly resulting from recent recombination events. Surprisingly, key components of the mating and meiosis pathways are missing from several species. These include major differences at the mating-type loci (MTL); Lodderomyces elongisporus lacks MTL, and components of the a1/2 cell identity determinant were lost in other species, raising questions about how mating and cell types are controlled. Analysis of the CUG leucine-to-serine genetic-code change reveals that 99% of ancestral CUG codons were erased and new ones arose elsewhere. Lastly, we revise the Candida albicans gene catalogue, identifying many new genes.
Title: The diploid genome sequence of Candida albicansJones T , Federspiel NA , Chibana H , Dungan J , Kalman S , Magee BB , Newport G , Thorstenson YR , Agabian N and Scherer S <2 more author(s)> Jones T , Federspiel NA , Chibana H , Dungan J , Kalman S , Magee BB , Newport G , Thorstenson YR , Agabian N , Magee PT , Davis RW , Scherer S (- 2) Ref: Proc Natl Acad Sci U S A, 101 :7329, 2004 : PubMed Abstract ESTHER: Jones_2004_Proc.Natl.Acad.Sci.U.S.A_101_7329 PubMedSearch: Jones 2004 Proc.Natl.Acad.Sci.U.S.A 101 7329 PubMedID: 15123810 Gene_locus related to this paper: canal-apth1 ,
canal-ATG15 ,
canal-bna7 ,
canal-c4yl13 ,
canal-cbpy ,
canal-LIP1 ,
canal-LIP2 ,
canal-LIP3 ,
canal-LIP4 ,
canal-LIP5 ,
canal-LIP6 ,
canal-LIP7 ,
canal-LIP8 ,
canal-LIP9 ,
canal-LIP10 ,
canal-ppme1 ,
canal-q5a0c9 ,
canal-q5a0i7 ,
canal-q5a2i9 ,
canal-q5a2u7 ,
canal-q5a6l4 ,
canal-q5a042 ,
canal-q5a948 ,
canal-q5aa97 ,
canal-q5abf2 ,
canal-q5acl5 ,
canal-q5ad17 ,
canal-q5adx4 ,
canal-q5ady2 ,
canal-q5aeu3 ,
canal-q5afp8 ,
canal-q5ag57 ,
canal-q5ah37 ,
canal-q5ai09 ,
canal-q5ai12 ,
canal-q5ai87 ,
canal-q5ajt3 ,
canal-q5ak09 ,
canal-q5ak29 ,
canal-q5ak96 ,
canal-q5akr2 ,
canal-q5akz5 ,
canal-q5amg8 ,
canal-q5amn4 ,
canal-q5amn7 ,
canal-q5ams2 ,
canal-q5ams7 ,
canal-q5apu4 ,
canal-q59k70 ,
canal-q59kl3 ,
canal-q59l46 ,
canal-q59ln6 ,
canal-q59m48 ,
canal-q59ng0 ,
canal-q59nl9 ,
canal-q59nw6 ,
canal-q59nx4 ,
canal-q59nx8 ,
canal-q59s22 ,
canal-q59tt5 ,
canal-q59u61 ,
canal-q59u64 ,
canal-q59vf1 ,
canal-q59vp0 ,
canal-q59we9 ,
canal-q59xq6 ,
canal-q59y42 ,
canal-q59y97 ,
canaw-c4yrr3 ,
canal-hda1 Abstract
We present the diploid genome sequence of the fungal pathogen Candida albicans. Because C. albicans has no known haploid or homozygous form, sequencing was performed as a whole-genome shotgun of the heterozygous diploid genome in strain SC5314, a clinical isolate that is the parent of strains widely used for molecular analysis. We developed computational methods to assemble a diploid genome sequence in good agreement with available physical mapping data. We provide a whole-genome description of heterozygosity in the organism. Comparative genomic analyses provide important clues about the evolution of the species and its mechanisms of pathogenesis.
Other Papers
