Gene_locus Report for: canal-q59u64 Candida albicans (strains SC5314 / ATCC MYA-2876; WO-1) (Yeast) Putative uncharacterized protein
Comment
only Pfam A Abhydro_lipase 106 168 Relationship
(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.) cellular organisms: N E > Eukaryota: N E > Opisthokonta: N E > Fungi: N E > Dikarya: N E > Ascomycota: N E > saccharomyceta: N E > Saccharomycotina: N E > Saccharomycetes: N E > Saccharomycetales: N E > Debaryomycetaceae: N E > Candida/Lodderomyces clade: N E > Candida [Debaryomycetaceae]: N E > Candida albicans: N E abh_upf0017 :
canal-q5ai12 Candida albicans (strains WO-1; SC5314) Candida dubliniensis (strain CD36 / CBS 7987 / NCPF 3949 / NRR Y-17841) (Yeast) hypothetical protein eht1 .
Arb2_domain :
canal-hda1 Candida albicans (Yeast). Histone deacetylase HDA1 .
Carboxypeptidase_S10 :
canal-cbpy Candida albicans carboxypeptidase Y (CPY1) ,
canal-q5afp8 Candida albicans (strain WO-1; SC5314 / ATCC MYA-2876) (Yeast) Carboxypeptidase D hypothetical protein kex1 .
CGI-58_ABHD5_ABHD4 :
canal-q5a0c9 Candida albicans (strains WO-1; SC5314) (Yeast) Candida dubliniensis (strain CD36 / CBS 7987 / NCPF 3949 / NRR Y-17841) hypothetical protein YGR110W homologue ,
canal-q5aeu3 Candida albicans (strain; SC5314; WO-1) (Yeast) potential mitochondrial protein involved in cell wall biogenesis .
Duf_726 :
canal-c4yl13 Candida albicans (Yeast) Putative uncharacterized protein .
Epoxide_hydrolase :
canal-q5ady2 Candida albicans, Candida dubliniensis, potential epoxide hydrolase .
Fungal-Bact_LIP :
canal-LIP1 Candida albicans (Yeast) secretory lipase 1 (EC 3.1.1.3) ,
canal-LIP2 Candida albicans (Yeast) Candida dubliniensis secretory lipase (EC 3.1.1.3) ,
canal-LIP3 Candida albicans (Yeast) secretory lipase 3 (EC 3.1.1.3) ,
canal-LIP4 Candida albicans (Yeast) Candida albicans secretory lipase 4 (EC 3.1.1.3) ,
canal-LIP5 Candida albicans (Yeast) Candida albicans SC5314 secretory lipase 5 (EC 3.1.1.3) ,
canal-LIP6 Candida albicans (Yeast) Candida albicans SC5314 Candida dubliniensis (strain CD36 / CBS 7987 / NCPF 3949 / NRRY-17841) secretory lipase 6 (EC 3.1.1.3) ,
canal-LIP7 Candida albicans (Yeast) Candida albicans SC5314 secretory lipase 7 (EC 3.1.1.3) ,
canal-LIP8 Candida albicans (Yeast) Candida albicans SC5314 secretory lipase 8 (EC 3.1.1.3) ,
canal-LIP9 Candida albicans (Yeast and Candida albicans SC5314) secretory lipase 9 (EC 3.1.1.3) ,
canal-LIP10 Candida albicans (Yeast) Candida albicans SC5314 secretory lipase 10 (EC 3.1.1.3) .
Kynurenine-formamidase :
canal-bna7 Candida albicans (Yeast) Probable N-formylkynurenine formamidase .
LIDHydrolase :
canal-q5a042 Candida albicans (Yeast) Putative uncharacterized protein .
Lipase_3 :
canal-ATG15 Candida albicans (Yeast), Candida tropicalis, Candida dubliniensis, putative lipase atg15 (EC 3.1.1.3) (autophagy-related protein 15) .
Monoglyceridelipase_lysophospholip :
canal-q5ah37 Candida albicans SC5314 (Yeast) hypothetical protein yju99 .
Steryl_acetyl_hydrolase :
canal-q5a2u7 Candida albicans (Yeast) Potential esterase/lipase ,
canal-q5ak09 Candida albicans (Yeast) Potential esterase/lipase ,
canal-q5ak96 Candida albicans (Yeast) Potential esterase/lipase ,
canal-q59l46 Candida albicans (Yeast) Potential esterase/lipase ,
canal-q59nx4 Candida albicans (Yeast) Potential esterase/lipase ,
canal-q59nx8 Candida albicans (Yeast) Potential esterase/lipase ,
canaw-c4ykb1 Candida albicans (strain WO-1) (Yeast) Putative uncharacterized protein ,
canaw-c4yrn6 Candida albicans (strain WO-1) (Yeast) Putative uncharacterized protein ,
canaw-c4yrn9 Candida albicans (strain WO-1) (Yeast) Putative uncharacterized protein ,
canaw-c4yrr3 Candida albicans (Yeast) Putative uncharacterized protein ,
canaw-c4yrv3 Candida albicans (strain WO-1) (Yeast) Putative uncharacterized protein ,
canaw-c4ys26 Candida albicans (strain WO-1) (Yeast) Putative uncharacterized protein Warning: This entry is a compilation of different species or line or strain with more than 90% amino acide identity. You can
retrieve all strain data
(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.) Candida albicans SC5314:
N ,
E .
Candida albicans WO-1:
N ,
E .
Molecular evidence
Database
No mutation No structure No kinetic No Substrate No inhibitor
Sequence
Graphical view for this peptide sequence: canal-q59u64 Colored MSA for Acidic_Lipase (raw)
SDLQYYLQQLNLDLQEYRVTTCDGYILTLHRIIDPRESEEQRQQRKPVLL
QHGLLSCSGTWIVSGKNSLGYYFHEQGYDVWMGNNRSWFIPQHKTLSGSL
YNNEQYWDWGVQELAYHDLPALISTVLANKKYFQKLVLLGHSQGGLQSFL
MLKNPRLGEIHEKVELFCPLAPAVYPGKLFYTRQFIKFINNRSEFMWLIL
FGCCAFLRNLCLVRHYIASSWLFGKLSYYMFKYLFGWTGRNWGPYKKVWH
FCFIFNMSYASVELMKYYLSKHSDCGFTTLLQPKAAYSSDAHFTENVTDD
KKSYFQFDTTWFSGIKVPMIVFIGDEDFLVDGEKVVAHMRKYEPGYREGS
NFEAVSIPTYNHLDIVWAEDVIGTIGYTICNKLKQMKARDVQEGLTSESK
EQAV
Legend
This sequence has been compared to family alignement (MSA) red => minority aminoacid blue => majority aminoacid color intensity => conservation rate title => sequence position(MSA position)aminoacid rate Catalytic site Catalytic site in the MSA
S D L Q Y Y L Q Q L N L D L Q E Y R V T T C D G Y I L T L H R I I D P R E S E E Q R Q Q R K P V L L Q H G L L S C S G T W I V S G K N S L G Y Y F H E Q G Y D V W M G N N R S W F I P Q H K T L S G S L Y N N E Q Y W D W G V Q E L A Y H D L P A L I S T V L A N K K Y F Q K L V L L G H S Q G G L Q S F L M L K N P R L G E I H E K V E L F C P L A P A V Y P G K L F Y T R Q F I K F I N N R S E F M W L I L F G C C A F L R N L C L V R H Y I A S S W L F G K L S Y Y M F K Y L F G W T G R N W G P Y K K V W H F C F I F N M S Y A S V E L M K Y Y L S K H S D C G F T T L L Q P K A A Y S S D A H F T E N V T D D K K S Y F Q F D T T W F S G I K V P M I V F I G D E D F L V D G E K V V A H M R K Y E P G Y R E G S N F E A V S I P T Y N H L D I V W A E D V I G T I G Y T I C N K L K Q M K A R D V Q E G L T S E S K E Q A V
References
Title: Evolution of pathogenicity and sexual reproduction in eight Candida genomesButler G , Rasmussen MD , Lin MF , Santos MA , Sakthikumar S , Munro CA , Rheinbay E , Grabherr M , Forche A and Cuomo CA <41 more author(s)> Butler G , Rasmussen MD , Lin MF , Santos MA , Sakthikumar S , Munro CA , Rheinbay E , Grabherr M , Forche A , Reedy JL , Agrafioti I , Arnaud MB , Bates S , Brown AJ , Brunke S , Costanzo MC , Fitzpatrick DA , de Groot PW , Harris D , Hoyer LL , Hube B , Klis FM , Kodira C , Lennard N , Logue ME , Martin R , Neiman AM , Nikolaou E , Quail MA , Quinn J , Santos MC , Schmitzberger FF , Sherlock G , Shah P , Silverstein KA , Skrzypek MS , Soll D , Staggs R , Stansfield I , Stumpf MP , Sudbery PE , Srikantha T , Zeng Q , Berman J , Berriman M , Heitman J , Gow NA , Lorenz MC , Birren BW , Kellis M , Cuomo CA (- 41) Ref: Nature, 459 :657, 2009 : PubMed Abstract ESTHER: Butler_2009_Nature_459_657 PubMedSearch: Butler 2009 Nature 459 657 PubMedID: 19465905 Gene_locus related to this paper: canal-ATG15 ,
canal-bna7 ,
canal-c4yl13 ,
canal-LIP1 ,
canal-LIP2 ,
canal-LIP3 ,
canal-LIP4 ,
canal-LIP5 ,
canal-LIP6 ,
canal-LIP7 ,
canal-LIP8 ,
canal-LIP9 ,
canal-LIP10 ,
canal-ppme1 ,
canal-q5a0c9 ,
canal-q5a2i9 ,
canal-q5a042 ,
canal-q5ad17 ,
canal-q5aeu3 ,
canal-q5afp8 ,
canal-q5ag57 ,
canal-q5ai09 ,
canal-q5ai12 ,
canal-q5ajt3 ,
canal-q5akz5 ,
canal-q5apu4 ,
canal-q59l46 ,
canal-q59m48 ,
canal-q59nw6 ,
canal-q59u61 ,
canal-q59u64 ,
canal-q59vp0 ,
canal-q59y97 ,
canaw-c4ykb1 ,
canaw-c4yrn6 ,
canaw-c4yrn9 ,
canaw-c4yrr3 ,
canaw-c4yrv3 ,
canaw-c4ys26 ,
cantt-c5m3d7 ,
cantt-c5m3y5 ,
cantt-c5m4x0 ,
cantt-c5m5e8 ,
cantt-c5m5w2 ,
cantt-c5m8s7 ,
cantt-c5m9c2 ,
cantt-c5m465 ,
cantt-c5m751 ,
cantt-c5m793 ,
cantt-c5m893 ,
cantt-c5ma78 ,
cantt-c5mag0 ,
cantt-c5mbb8 ,
cantt-c5mc53 ,
cantt-c5md87 ,
cantt-c5mdy3 ,
cantt-c5mey7 ,
cantt-c5mfg0 ,
cantt-c5mfh8 ,
cantt-c5mg56 ,
cantt-c5mgj0 ,
cantt-c5mh75 ,
cantt-c5mh80 ,
cantt-c5mh89 ,
cantt-c5mhh0 ,
cantt-c5mhn5 ,
cantt-c5mij5 ,
cantt-c5min7 ,
clal4-c4xvt8 ,
clal4-c4xwy4 ,
clal4-c4xy03 ,
clal4-c4xyx9 ,
clal4-c4xzz1 ,
clal4-c4y3e1 ,
clal4-c4y4f2 ,
clal4-c4y4w8 ,
clal4-c4y5j4 ,
clal4-c4y5j9 ,
clal4-c4y7z7 ,
clal4-c4y8q1 ,
clal4-c4y035 ,
clal4-c4y481 ,
clal4-c4y538 ,
clal4-c4y898 ,
clal4-c4yas2 ,
clal4-c4yba6 ,
clal4-c4yba7 ,
clal4-c4yc85 ,
lodel-a5drz3 ,
lodel-a5ds97 ,
lodel-a5dsc0 ,
lodel-a5duu4 ,
lodel-a5duy7 ,
lodel-a5dv03 ,
lodel-a5dv46 ,
lodel-a5dw16 ,
lodel-a5dwv7 ,
lodel-a5dww6 ,
lodel-a5dxf3 ,
lodel-a5e0z5 ,
lodel-a5e1c1 ,
lodel-a5e1l4 ,
lodel-a5e1p3 ,
lodel-a5e2s1 ,
lodel-a5e2t8 ,
lodel-a5e2v2 ,
lodel-a5e4u8 ,
lodel-a5e5a9 ,
lodel-a5e5k1 ,
lodel-a5e5z7 ,
lodel-a5e6w1 ,
lodel-a5e028 ,
lodel-atg15 ,
lodel-kex1 ,
picgu-a5d9u2 ,
picgu-a5dav0 ,
picgu-a5dbk0 ,
picgu-a5dc45 ,
picgu-a5dc73 ,
picgu-a5dc74 ,
picgu-a5dc75 ,
picgu-a5ddt8 ,
picgu-a5dev7 ,
picgu-a5dh90 ,
picgu-a5dhe3 ,
picgu-a5di38 ,
picgu-a5dj06 ,
picgu-a5dkd8 ,
picgu-a5dle9 ,
picgu-a5dlj5 ,
picgu-a5dm19 ,
picgu-a5dn92 ,
picgu-a5dnr3 ,
picgu-a5dnt6 ,
picgu-a5dqu5 ,
picgu-a5dr14 ,
picgu-a5drl3 ,
picgu-atg15 ,
picgu-bna7 ,
picgu-a5d9q3 ,
picgu-a5dag9 ,
clal4-c4y5a2 ,
clal4-c4y0l0 ,
cantt-c5mcb1 ,
clal4-c4y8j2 ,
cantt-c5m494 ,
clals-a0a202gac7 ,
canal-hda1 ,
picgu-a5dks8 ,
lodel-a5drs6 ,
canpc-g8bbk1 ,
cantt-kex1 ,
clal4-kex1 ,
picgu-kex1 Abstract
Candida species are the most common cause of opportunistic fungal infection worldwide. Here we report the genome sequences of six Candida species and compare these and related pathogens and non-pathogens. There are significant expansions of cell wall, secreted and transporter gene families in pathogenic species, suggesting adaptations associated with virulence. Large genomic tracts are homozygous in three diploid species, possibly resulting from recent recombination events. Surprisingly, key components of the mating and meiosis pathways are missing from several species. These include major differences at the mating-type loci (MTL); Lodderomyces elongisporus lacks MTL, and components of the a1/2 cell identity determinant were lost in other species, raising questions about how mating and cell types are controlled. Analysis of the CUG leucine-to-serine genetic-code change reveals that 99% of ancestral CUG codons were erased and new ones arose elsewhere. Lastly, we revise the Candida albicans gene catalogue, identifying many new genes.
Title: The diploid genome sequence of Candida albicansJones T , Federspiel NA , Chibana H , Dungan J , Kalman S , Magee BB , Newport G , Thorstenson YR , Agabian N and Scherer S <2 more author(s)> Jones T , Federspiel NA , Chibana H , Dungan J , Kalman S , Magee BB , Newport G , Thorstenson YR , Agabian N , Magee PT , Davis RW , Scherer S (- 2) Ref: Proc Natl Acad Sci U S A, 101 :7329, 2004 : PubMed Abstract ESTHER: Jones_2004_Proc.Natl.Acad.Sci.U.S.A_101_7329 PubMedSearch: Jones 2004 Proc.Natl.Acad.Sci.U.S.A 101 7329 PubMedID: 15123810 Gene_locus related to this paper: canal-apth1 ,
canal-ATG15 ,
canal-bna7 ,
canal-c4yl13 ,
canal-cbpy ,
canal-LIP1 ,
canal-LIP2 ,
canal-LIP3 ,
canal-LIP4 ,
canal-LIP5 ,
canal-LIP6 ,
canal-LIP7 ,
canal-LIP8 ,
canal-LIP9 ,
canal-LIP10 ,
canal-ppme1 ,
canal-q5a0c9 ,
canal-q5a0i7 ,
canal-q5a2i9 ,
canal-q5a2u7 ,
canal-q5a6l4 ,
canal-q5a042 ,
canal-q5a948 ,
canal-q5aa97 ,
canal-q5abf2 ,
canal-q5acl5 ,
canal-q5ad17 ,
canal-q5adx4 ,
canal-q5ady2 ,
canal-q5aeu3 ,
canal-q5afp8 ,
canal-q5ag57 ,
canal-q5ah37 ,
canal-q5ai09 ,
canal-q5ai12 ,
canal-q5ai87 ,
canal-q5ajt3 ,
canal-q5ak09 ,
canal-q5ak29 ,
canal-q5ak96 ,
canal-q5akr2 ,
canal-q5akz5 ,
canal-q5amg8 ,
canal-q5amn4 ,
canal-q5amn7 ,
canal-q5ams2 ,
canal-q5ams7 ,
canal-q5apu4 ,
canal-q59k70 ,
canal-q59kl3 ,
canal-q59l46 ,
canal-q59ln6 ,
canal-q59m48 ,
canal-q59ng0 ,
canal-q59nl9 ,
canal-q59nw6 ,
canal-q59nx4 ,
canal-q59nx8 ,
canal-q59s22 ,
canal-q59tt5 ,
canal-q59u61 ,
canal-q59u64 ,
canal-q59vf1 ,
canal-q59vp0 ,
canal-q59we9 ,
canal-q59xq6 ,
canal-q59y42 ,
canal-q59y97 ,
canaw-c4yrr3 ,
canal-hda1 Abstract
We present the diploid genome sequence of the fungal pathogen Candida albicans. Because C. albicans has no known haploid or homozygous form, sequencing was performed as a whole-genome shotgun of the heterozygous diploid genome in strain SC5314, a clinical isolate that is the parent of strains widely used for molecular analysis. We developed computational methods to assemble a diploid genome sequence in good agreement with available physical mapping data. We provide a whole-genome description of heterozygosity in the organism. Comparative genomic analyses provide important clues about the evolution of the species and its mechanisms of pathogenesis.
Other Papers
