(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.) > cellular organisms: NE > Eukaryota: NE > Opisthokonta: NE > Fungi: NE > Dikarya: NE > Ascomycota: NE > saccharomyceta: NE > Saccharomycotina: NE > Saccharomycetes: NE > Saccharomycetales: NE > Debaryomycetaceae: NE > Candida/Lodderomyces clade: NE > Candida [Debaryomycetaceae]: NE > Candida tropicalis: NE
LegendThis sequence has been compared to family alignement (MSA) red => minority aminoacid blue => majority aminoacid color intensity => conservation rate title => sequence position(MSA position)aminoacid rate Catalytic site Catalytic site in the MSA MFTRKQPHHEEYEMVDQSVPRHHTNTSSDSISTPAEGSVSDSRSSSDSQT SDVFDDLENLSAESGQKVEDFYDSPVFQSIFNRYTNKGFNPKACWIFSLC IIILWLGTLILYSQMNPSNLISSLRWKTSIVQLNGENITINEYSPSYKNL SLYDWRTGRYYIPEKQIRWLTPHQNPKIKSGSGFYAVNEHGKLVIQQVNS DSKDVLISNSRFAYGNDFFEIQDFILNPMNSAEELDNTHILITDRLEQWR HSSFALYWLFNPLTFKYTPIQPPESKKKLETQEDPFAPRVLQKLHYADFS PDGKFVYFAFEHDLYLHDLSTNEVHQITKDGSPNIFNGKSDWIYEEEVNA QDRMIWWSPDSSQFIFAKINDTNVREVELDYYAKANSEVTNQYQVPNEPE MGGVNQYPIKTSLKYPKPGTPNPIISLYNYNVNTKKVKQLNDDDTRLGVD KILYDAKWIDSKNFLMKQTDRTSSILSKKLYQPEKHEVRVINSTNVTADY NGWVEKMSPMTNLEDGKYIDNIVVDNRNVLAVFDNPEQSTPSKILMENQN WEVIGKAVYDKQEKFIYFMSTIKSSMDSHLLGIDMADNYKMYNITNTTSD AYYEADFSIDGQFLNLKYQGPDEPWQRLIDMGDVHDYIKGEEFDESLIEQ EVILKQPIISGRTDLRNTNIPTSRFKEVTIGNPKDEVSLNVMEILPPNFK PSKYKYPLFVHTYGGPGSQNIYKKFDIGFLQIISAKLNCIVLVIDPRGTG GKGWKFRSYANQKLGYWEPRDLTLVTSEYISKNKDIINKDRVALWGWSYG GFVTLKTLEVDKGETFKYGMAVSPVTNWLFYDSIYTERYMNEPSMNPNYE AFGKINEIENFKSVQRFLMMHGTGDDNVHIQNSMWLLDKFNAGNVENYDV QFFPDSDHGITYDNAGIIVFDKLYNWLDDAFKGRFDNLL
Candida species are the most common cause of opportunistic fungal infection worldwide. Here we report the genome sequences of six Candida species and compare these and related pathogens and non-pathogens. There are significant expansions of cell wall, secreted and transporter gene families in pathogenic species, suggesting adaptations associated with virulence. Large genomic tracts are homozygous in three diploid species, possibly resulting from recent recombination events. Surprisingly, key components of the mating and meiosis pathways are missing from several species. These include major differences at the mating-type loci (MTL); Lodderomyces elongisporus lacks MTL, and components of the a1/2 cell identity determinant were lost in other species, raising questions about how mating and cell types are controlled. Analysis of the CUG leucine-to-serine genetic-code change reveals that 99% of ancestral CUG codons were erased and new ones arose elsewhere. Lastly, we revise the Candida albicans gene catalogue, identifying many new genes.
