Gene_locus Report for: cantt-c5mfh8 Candida tropicalis (strain ATCC MYA-3404 / T1) (Yeast) Carboxypeptidase Y
Relationship
(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.) cellular organisms: N E > Eukaryota: N E > Opisthokonta: N E > Fungi: N E > Dikarya: N E > Ascomycota: N E > saccharomyceta: N E > Saccharomycotina: N E > Saccharomycetes: N E > Saccharomycetales: N E > Debaryomycetaceae: N E > Candida/Lodderomyces clade: N E > Candida [Debaryomycetaceae]: N E > Candida tropicalis: N E A85-EsteraseD-FGH :
cantt-c5mij5 Candida tropicalis (strain ATCC MYA-3404 / T1) (Yeast) Esterase D .
abh_upf0017 :
cantt-c5m793 Candida tropicalis (strain ATCC MYA-3404 / T1) (Yeast) Putative uncharacterized protein ,
cantt-c5mfg0 Candida tropicalis (strain ATCC MYA-3404 / T1) (Yeast) Putative uncharacterized protein .
Acidic_Lipase :
cantt-c5m751 Candida tropicalis (strain ATCC MYA-3404 / T1) (Yeast) Putative uncharacterized protein ,
cantt-c5mc53 Candida tropicalis (strain ATCC MYA-3404 / T1) (Yeast) Putative uncharacterized protein ,
cantt-c5mey7 Candida tropicalis (strain ATCC MYA-3404 / T1) (Yeast) Putative uncharacterized protein .
Arb2_domain :
cantt-c5m494 Candida tropicalis (strain ATCC MYA-3404 / T1) (Yeast). Histone deacetylase HDA1 .
Carboxypeptidase_S10 :
cantt-kex1 Candida tropicalis (strain ATCC MYA-3404 / T1) (Yeast). Carboxypeptidase D .
CGI-58_ABHD5_ABHD4 :
cantt-c5m4x0 Candida tropicalis (strain ATCC MYA-3404 / T1) (Yeast) Putative uncharacterized protein ,
cantt-c5m9c2 Candida tropicalis (strain ATCC MYA-3404 / T1) (Yeast) Putative uncharacterized protein ,
cantt-c5m893 Candida tropicalis (strain ATCC MYA-3404 / T1) (Yeast) Putative uncharacterized protein ,
cantt-c5mgj0 Candida tropicalis (strain ATCC MYA-3404 / T1) (Yeast) Putative uncharacterized protein .
DPP4N_Peptidase_S9 :
cantt-c5m3d7 Candida tropicalis (strain ATCC MYA-3404 / T1) (Yeast) Putative uncharacterized protein ,
cantt-c5mh75 Candida tropicalis (strain ATCC MYA-3404 / T1) (Yeast) Putative uncharacterized protein .
Duf_726 :
cantt-c5m465 Candida tropicalis (strain ATCC MYA-3404 / T1) (Yeast) Putative uncharacterized protein .
Epoxide_hydrolase :
cantt-c5mhn5 Candida tropicalis (strain ATCC MYA-3404 / T1) (Yeast) Putative uncharacterized protein .
Fungal-Bact_LIP :
cantt-c5m8s7 Candida tropicalis (strain ATCC MYA-3404 / T1) (Yeast) Lipase 1 ,
cantt-c5mag0 Candida tropicalis (strain ATCC MYA-3404 / T1) (Yeast) Lipase 4, CtroL4 ,
cantt-c5md87 Candida tropicalis (strain ATCC MYA-3404 / T1) (Yeast) Lipase 1 ,
cantt-c5mdy3 Candida tropicalis (strain ATCC MYA-3404 / T1) (Yeast) Predicted protein ,
cantt-c5min7 Candida tropicalis (strain ATCC MYA-3404 / T1) (Yeast) Predicted protein .
Fusarinine_C_esterase_sidJ :
cantt-c5ma78 Candida tropicalis (strain ATCC MYA-3404 / T1) (Yeast) Putative uncharacterized protein .
Kynurenine-formamidase :
cantt-c5mcb1 Candida tropicalis (strain ATCC MYA-3404 / T1) (Yeast). N-formylkynurenine formamidase .
LIDHydrolase :
cantt-c5m3y5 Candida tropicalis (strain ATCC MYA-3404 / T1) (Yeast) Putative uncharacterized protein .
Monoglyceridelipase_lysophospholip :
cantt-c5mbb8 Candida tropicalis (strain ATCC MYA-3404 / T1) (Yeast) Putative uncharacterized protein ,
cantt-c5mg56 Candida tropicalis (strain ATCC MYA-3404 / T1) (Yeast) Predicted protein .
PPase_methylesterase_euk :
cantt-c5m5w2 Candida tropicalis (strain ATCC MYA-3404 / T1) (Yeast) Protein phosphatase methylesterase 1 .
Steryl_acetyl_hydrolase :
cantt-c5m5e8 Candida tropicalis (strain ATCC MYA-3404 / T1) (Yeast) Putative uncharacterized protein ,
cantt-c5mh80 Candida tropicalis (strain ATCC MYA-3404 / T1) (Yeast) Putative uncharacterized protein ,
cantt-c5mh89 Candida tropicalis (strain ATCC MYA-3404 / T1) (Yeast) Putative uncharacterized protein ,
cantt-c5mhh0 Candida tropicalis (strain ATCC MYA-3404 / T1) (Yeast) Putative uncharacterized protein Molecular evidence
Database
No mutation No structure No kinetic No Substrate No inhibitor
Sequence
Graphical view for this peptide sequence: cantt-c5mfh8 Colored MSA for Carboxypeptidase_S10 (raw)
MKAFTLFNTVVALGATAQAAYLGNQFKDQVVFTSDDNAAEFQFETFFKQL
GTSPLDLVTAWADMQSELTPAQIAALIRQYQTKDEKPKKNTFNDISAAST
SDFEILSNEKFADYSLRIKETFPEILGLDTVKQYTGYLDIDSLNKHFFYW
FFESRNDPKNDPIILWLNGGPGCSSSTGLFFELGPSSINSTLQPVYNPYS
WNSNASVIFLDQPVGVGYSYTGGEQVRNTATAAKDVFVFLELFFQKFPQF
IQNKFHIAGESYAGHYIPAFASEIINNADRSFELASVLIGNGITDPLIQS
GSYKPMGCGEGGYKAVLTPEQCDQMEKDYPKCAKLTQLCYDIQTALTCVP
AQYYCDSHLFQPYAQTGLNPYDIRKDCADQGGNCYVEMDYMDDYLNLDYV
KQAVGASNIDIFTSCDDTVFRNFILDGDEMKPFQQYVAELLDHNVPVLLY
AGDKDYICNWLGNLAWANKLEYSDGDVFSKKDLQPWKPDGKVVAGEVKNH
KHFTFLRVYDAGHMVPYDQPENALSMVNTWLQGDYSFGIKQE
Legend
This sequence has been compared to family alignement (MSA) red => minority aminoacid blue => majority aminoacid color intensity => conservation rate title => sequence position(MSA position)aminoacid rate Catalytic site Catalytic site in the MSA
M K A F T L F N T V V A L G A T A Q A A Y L G N Q F K D Q V V F T S D D N A A E F Q F E T F F K Q L G T S P L D L V T A W A D M Q S E L T P A Q I A A L I R Q Y Q T K D E K P K K N T F N D I S A A S T S D F E I L S N E K F A D Y S L R I K E T F P E I L G L D T V K Q Y T G Y L D I D S L N K H F F Y W F F E S R N D P K N D P I I L W L N G G P G C S S S T G L F F E L G P S S I N S T L Q P V Y N P Y S W N S N A S V I F L D Q P V G V G Y S Y T G G E Q V R N T A T A A K D V F V F L E L F F Q K F P Q F I Q N K F H I A G E S Y A G H Y I P A F A S E I I N N A D R S F E L A S V L I G N G I T D P L I Q S G S Y K P M G C G E G G Y K A V L T P E Q C D Q M E K D Y P K C A K L T Q L C Y D I Q T A L T C V P A Q Y Y C D S H L F Q P Y A Q T G L N P Y D I R K D C A D Q G G N C Y V E M D Y M D D Y L N L D Y V K Q A V G A S N I D I F T S C D D T V F R N F I L D G D E M K P F Q Q Y V A E L L D H N V P V L L Y A G D K D Y I C N W L G N L A W A N K L E Y S D G D V F S K K D L Q P W K P D G K V V A G E V K N H K H F T F L R V Y D A G H M V P Y D Q P E N A L S M V N T W L Q G D Y S F G I K Q E
Reference
Title: Evolution of pathogenicity and sexual reproduction in eight Candida genomesButler G , Rasmussen MD , Lin MF , Santos MA , Sakthikumar S , Munro CA , Rheinbay E , Grabherr M , Forche A and Cuomo CA <41 more author(s)> Butler G , Rasmussen MD , Lin MF , Santos MA , Sakthikumar S , Munro CA , Rheinbay E , Grabherr M , Forche A , Reedy JL , Agrafioti I , Arnaud MB , Bates S , Brown AJ , Brunke S , Costanzo MC , Fitzpatrick DA , de Groot PW , Harris D , Hoyer LL , Hube B , Klis FM , Kodira C , Lennard N , Logue ME , Martin R , Neiman AM , Nikolaou E , Quail MA , Quinn J , Santos MC , Schmitzberger FF , Sherlock G , Shah P , Silverstein KA , Skrzypek MS , Soll D , Staggs R , Stansfield I , Stumpf MP , Sudbery PE , Srikantha T , Zeng Q , Berman J , Berriman M , Heitman J , Gow NA , Lorenz MC , Birren BW , Kellis M , Cuomo CA (- 41) Ref: Nature, 459 :657, 2009 : PubMed Abstract ESTHER: Butler_2009_Nature_459_657 PubMedSearch: Butler 2009 Nature 459 657 PubMedID: 19465905 Gene_locus related to this paper: canal-ATG15 ,
canal-bna7 ,
canal-c4yl13 ,
canal-LIP1 ,
canal-LIP2 ,
canal-LIP3 ,
canal-LIP4 ,
canal-LIP5 ,
canal-LIP6 ,
canal-LIP7 ,
canal-LIP8 ,
canal-LIP9 ,
canal-LIP10 ,
canal-ppme1 ,
canal-q5a0c9 ,
canal-q5a2i9 ,
canal-q5a042 ,
canal-q5ad17 ,
canal-q5aeu3 ,
canal-q5afp8 ,
canal-q5ag57 ,
canal-q5ai09 ,
canal-q5ai12 ,
canal-q5ajt3 ,
canal-q5akz5 ,
canal-q5apu4 ,
canal-q59l46 ,
canal-q59m48 ,
canal-q59nw6 ,
canal-q59u61 ,
canal-q59u64 ,
canal-q59vp0 ,
canal-q59y97 ,
canaw-c4ykb1 ,
canaw-c4yrn6 ,
canaw-c4yrn9 ,
canaw-c4yrr3 ,
canaw-c4yrv3 ,
canaw-c4ys26 ,
cantt-c5m3d7 ,
cantt-c5m3y5 ,
cantt-c5m4x0 ,
cantt-c5m5e8 ,
cantt-c5m5w2 ,
cantt-c5m8s7 ,
cantt-c5m9c2 ,
cantt-c5m465 ,
cantt-c5m751 ,
cantt-c5m793 ,
cantt-c5m893 ,
cantt-c5ma78 ,
cantt-c5mag0 ,
cantt-c5mbb8 ,
cantt-c5mc53 ,
cantt-c5md87 ,
cantt-c5mdy3 ,
cantt-c5mey7 ,
cantt-c5mfg0 ,
cantt-c5mfh8 ,
cantt-c5mg56 ,
cantt-c5mgj0 ,
cantt-c5mh75 ,
cantt-c5mh80 ,
cantt-c5mh89 ,
cantt-c5mhh0 ,
cantt-c5mhn5 ,
cantt-c5mij5 ,
cantt-c5min7 ,
clal4-c4xvt8 ,
clal4-c4xwy4 ,
clal4-c4xy03 ,
clal4-c4xyx9 ,
clal4-c4xzz1 ,
clal4-c4y3e1 ,
clal4-c4y4f2 ,
clal4-c4y4w8 ,
clal4-c4y5j4 ,
clal4-c4y5j9 ,
clal4-c4y7z7 ,
clal4-c4y8q1 ,
clal4-c4y035 ,
clal4-c4y481 ,
clal4-c4y538 ,
clal4-c4y898 ,
clal4-c4yas2 ,
clal4-c4yba6 ,
clal4-c4yba7 ,
clal4-c4yc85 ,
lodel-a5drz3 ,
lodel-a5ds97 ,
lodel-a5dsc0 ,
lodel-a5duu4 ,
lodel-a5duy7 ,
lodel-a5dv03 ,
lodel-a5dv46 ,
lodel-a5dw16 ,
lodel-a5dwv7 ,
lodel-a5dww6 ,
lodel-a5dxf3 ,
lodel-a5e0z5 ,
lodel-a5e1c1 ,
lodel-a5e1l4 ,
lodel-a5e1p3 ,
lodel-a5e2s1 ,
lodel-a5e2t8 ,
lodel-a5e2v2 ,
lodel-a5e4u8 ,
lodel-a5e5a9 ,
lodel-a5e5k1 ,
lodel-a5e5z7 ,
lodel-a5e6w1 ,
lodel-a5e028 ,
lodel-atg15 ,
lodel-kex1 ,
picgu-a5d9u2 ,
picgu-a5dav0 ,
picgu-a5dbk0 ,
picgu-a5dc45 ,
picgu-a5dc73 ,
picgu-a5dc74 ,
picgu-a5dc75 ,
picgu-a5ddt8 ,
picgu-a5dev7 ,
picgu-a5dh90 ,
picgu-a5dhe3 ,
picgu-a5di38 ,
picgu-a5dj06 ,
picgu-a5dkd8 ,
picgu-a5dle9 ,
picgu-a5dlj5 ,
picgu-a5dm19 ,
picgu-a5dn92 ,
picgu-a5dnr3 ,
picgu-a5dnt6 ,
picgu-a5dqu5 ,
picgu-a5dr14 ,
picgu-a5drl3 ,
picgu-atg15 ,
picgu-bna7 ,
picgu-a5d9q3 ,
picgu-a5dag9 ,
clal4-c4y5a2 ,
clal4-c4y0l0 ,
cantt-c5mcb1 ,
clal4-c4y8j2 ,
cantt-c5m494 ,
clals-a0a202gac7 ,
canal-hda1 ,
picgu-a5dks8 ,
lodel-a5drs6 ,
canpc-g8bbk1 ,
cantt-kex1 ,
clal4-kex1 ,
picgu-kex1 Abstract
Candida species are the most common cause of opportunistic fungal infection worldwide. Here we report the genome sequences of six Candida species and compare these and related pathogens and non-pathogens. There are significant expansions of cell wall, secreted and transporter gene families in pathogenic species, suggesting adaptations associated with virulence. Large genomic tracts are homozygous in three diploid species, possibly resulting from recent recombination events. Surprisingly, key components of the mating and meiosis pathways are missing from several species. These include major differences at the mating-type loci (MTL); Lodderomyces elongisporus lacks MTL, and components of the a1/2 cell identity determinant were lost in other species, raising questions about how mating and cell types are controlled. Analysis of the CUG leucine-to-serine genetic-code change reveals that 99% of ancestral CUG codons were erased and new ones arose elsewhere. Lastly, we revise the Candida albicans gene catalogue, identifying many new genes.
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