Gene_locus Report for: cavpo-h0w342 Cavia porcellus (Guinea pig). Hydrolase_4 domain-containing protein
Relationship
(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.) cellular organisms: N E > Eukaryota: N E > Opisthokonta: N E > Metazoa: N E > Eumetazoa: N E > Bilateria: N E > Deuterostomia: N E > Chordata: N E > Craniata: N E > Vertebrata: N E > Gnathostomata: N E > Teleostomi: N E > Euteleostomi: N E > Sarcopterygii: N E > Dipnotetrapodomorpha: N E > Tetrapoda: N E > Amniota: N E > Mammalia: N E > Theria: N E > Eutheria: N E > Boreoeutheria: N E > Euarchontoglires: N E > Glires: N E > Rodentia: N E > Hystricomorpha: N E > Caviidae: N E > Cavia: N E > Cavia porcellus: N E ABHD6-Lip :
cavpo-h0uwi9 Cavia porcellus (Guinea pig) Uncharacterized protein .
ABHD8 :
cavpo-h0v8y6 Cavia porcellus (Guinea pig). Abhydrolase domain containing 8 .
ABHD10 :
cavpo-h0v5z0 Cavia porcellus (Guinea pig). Abhydrolase domain containing 10 .
ABHD11-Acetyl_transferase :
cavpo-a0a286x9v5 Cavia porcellus (Guinea pig). AB hydrolase-1 domain-containing protein .
ABHD12-PHARC :
cavpo-h0v2c4 Cavia porcellus (Guinea pig). Uncharacterized protein .
ABHD16 :
cavpo-h0vhq3 Cavia porcellus (Guinea pig). Abhydrolase domain containing 16A ,
cavpo-h0vqx6 Cavia porcellus (Guinea pig). Abhydrolase domain containing 16B .
ABHD18 :
cavpo-h0v7s5 Cavia porcellus (Guinea pig). ABHD18 Uncharacterized protein .
abh_upf0017 :
cavpo-h0w2w1 Cavia porcellus (Guinea pig). Uncharacterized protein .
ACHE :
cavpo-d3ye96 Cavia porcellus (Guinea pig) Acetylcholinesterase .
Arylacetamide_deacetylase :
cavpo-h0v2i2 Cavia porcellus (Guinea pig). Uncharacterized protein ,
cavpo-h0v2j0 Cavia porcellus (Guinea pig). Uncharacterized protein ,
cavpo-h0vsf5 Cavia porcellus (Guinea pig). Uncharacterized protein .
BCHE :
cavpo-h0v4f8 Cavia porcellus (Guinea pig) Uncharacterized protein .
Carb_B_Chordata :
cavpo-cxest Cavia porcellus (Guinea pig) carboxylesterase ,
cavpo-h0v1b7 Cavia porcellus (Guinea pig) Uncharacterized protein ,
cavpo-h0v5v8 Cavia porcellus (Guinea pig) Uncharacterized protein ,
cavpo-h0v479 Cavia porcellus (Guinea pig) Uncharacterized protein ,
cavpo-h0vj36 Cavia porcellus (Guinea pig) Uncharacterized protein ,
cavpo-a0a286x8d3 Cavia porcellus (Guinea pig). Carboxylic ester hydrolase ,
cavpo-a0a286y0i8 Cavia porcellus (Guinea pig). Carboxylic ester hydrolase ,
cavpo-a0a286y4p3 Cavia porcellus (Guinea pig). Carboxylic ester hydrolase .
Cholesterol_esterase :
cavpo-h0uyx7 Cavia porcellus (Guinea pig) Uncharacterized protein .
CIB-CCG1-interacting-factor-B :
cavpo-h0v0r2 Cavia porcellus (Guinea pig). Uncharacterized protein .
CMBL :
cavpo-h0uxk7 Cavia porcellus (Guinea pig). Carboxymethylenebutenolidase homolog .
Hepatic_Lipase :
cavpo-h0v1p4 Cavia porcellus (Guinea pig). Lipase C, hepatic type .
Kynurenine-formamidase :
cavpo-h0vw09 Cavia porcellus (Guinea pig). N-formylkynurenine formamidase .
Lipoprotein_Lipase :
cavpo-lipli Cavia porcellus (Guinea pig). Lipoprotein lipase ,
cavpo-h0vdd5 Cavia porcellus (Guinea pig). Lipase G, endothelial type .
Maspardin-ACP33-SPG21_like :
cavpo-h0vkz6 Cavia porcellus (Guinea pig) Uncharacterized protein .
Ndr_family :
cavpo-h0uyz6 Cavia porcellus (Guinea pig) Uncharacterized protein ,
cavpo-h0vi56 Cavia porcellus (Guinea pig) Uncharacterized protein .
Neuroligin :
cavpo-h0v784 Cavia porcellus (Guinea pig) Uncharacterized protein ,
cavpo-h0wcp7 Cavia porcellus (Guinea pig) Uncharacterized protein ,
cavpo-a0a286xbr3 Cavia porcellus (Guinea pig). Neuroligin 3 .
NLS3-Tex30 :
cavpo-h0v5e0 Cavia porcellus (Guinea pig) Uncharacterized protein ,
cavpo-h0v8d7 Cavia porcellus (Guinea pig) Uncharacterized protein .
PAF-Acetylhydrolase :
cavpo-pafa Cavia porcellus (Guinea pig) plasma Paf-acetylhydrolase .
Pancreatic_lipase :
cavpo-1plip Cavia porcellus (Guinea pig) mRNA for pancreatic lipase ,
cavpo-2plrp .
PC-sterol_acyltransferase :
cavpo-lcat Cavia porcellus (Guinea pig) lecithin: cholesterol acyl-transferase (fragment) .
Phospholipase :
cavpo-h0v8j4 Cavia porcellus (Guinea pig). Phospholipase A1 member A ,
cavpo-h0vpm0 Cavia porcellus (Guinea pig). Lipase H ,
cavpo-a0a286xtc0 Cavia porcellus (Guinea pig). Lipase I .
Thyroglobulin :
cavpo-h0vf67 Cavia porcellus (Guinea pig) Uncharacterized protein .
Valacyclovir-hydrolase :
cavpo-h0uyf1 Cavia porcellus (Guinea pig) Uncharacterized protein Molecular evidence
Database
No mutation No structure No kinetic No Substrate No inhibitor
Sequence
Graphical view for this peptide sequence: cavpo-h0w342 Colored MSA for ABHD13-BEM46 (raw)
MEKSWVLWNFIERWLLALASWSWALCRISLLPLIVTFHLYGGFVLLLLIF
ISIAGILYKFQDVLLYFPEQPSSSRLYVPMPTGIPHENIFIRTKDGVRLN
LILIRYTGDSSPYSPTIIYFHGNAGNIGHRLPNALLMLVNLKVNLLLVDY
RGYGKSEGEASEDGLYLDSEAVLDYVMARPDIDKTKLFLFGRSLGGAVAI
HLASENSHRISAIMVENTFLSIPHMASTLFSFFPMRYLPLWCYKNKFLSY
RKISQCRMPSLFISGLSDQLIPPVMMKQLYELSPSRTKRLAIFPDGTHND
TWQCQGYFTALEQFIKEVIKSHSPEEMTKTSSSVTII
Legend
This sequence has been compared to family alignement (MSA) red => minority aminoacid blue => majority aminoacid color intensity => conservation rate title => sequence position(MSA position)aminoacid rate Catalytic site Catalytic site in the MSA
M E K S W V L W N F I E R W L L A L A S W S W A L C R I S L L P L I V T F H L Y G G F V L L L L I F I S I A G I L Y K F Q D V L L Y F P E Q P S S S R L Y V P M P T G I P H E N I F I R T K D G V R L N L I L I R Y T G D S S P Y S P T I I Y F H G N A G N I G H R L P N A L L M L V N L K V N L L L V D Y R G Y G K S E G E A S E D G L Y L D S E A V L D Y V M A R P D I D K T K L F L F G R S L G G A V A I H L A S E N S H R I S A I M V E N T F L S I P H M A S T L F S F F P M R Y L P L W C Y K N K F L S Y R K I S Q C R M P S L F I S G L S D Q L I P P V M M K Q L Y E L S P S R T K R L A I F P D G T H N D T W Q C Q G Y F T A L E Q F I K E V I K S H S P E E M T K T S S S V T I I
Reference
Title: A high-resolution map of human evolutionary constraint using 29 mammalsLindblad-Toh K , Garber M , Zuk O , Lin MF , Parker BJ , Washietl S , Kheradpour P , Ernst J , Jordan G and Kellis M <76 more author(s)> Lindblad-Toh K , Garber M , Zuk O , Lin MF , Parker BJ , Washietl S , Kheradpour P , Ernst J , Jordan G , Mauceli E , Ward LD , Lowe CB , Holloway AK , Clamp M , Gnerre S , Alfoldi J , Beal K , Chang J , Clawson H , Cuff J , Di Palma F , Fitzgerald S , Flicek P , Guttman M , Hubisz MJ , Jaffe DB , Jungreis I , Kent WJ , Kostka D , Lara M , Martins AL , Massingham T , Moltke I , Raney BJ , Rasmussen MD , Robinson J , Stark A , Vilella AJ , Wen J , Xie X , Zody MC , Baldwin J , Bloom T , Chin CW , Heiman D , Nicol R , Nusbaum C , Young S , Wilkinson J , Worley KC , Kovar CL , Muzny DM , Gibbs RA , Cree A , Dihn HH , Fowler G , Jhangiani S , Joshi V , Lee S , Lewis LR , Nazareth LV , Okwuonu G , Santibanez J , Warren WC , Mardis ER , Weinstock GM , Wilson RK , Delehaunty K , Dooling D , Fronik C , Fulton L , Fulton B , Graves T , Minx P , Sodergren E , Birney E , Margulies EH , Herrero J , Green ED , Haussler D , Siepel A , Goldman N , Pollard KS , Pedersen JS , Lander ES , Kellis M (- 76) Ref: Nature, 478 :476, 2011 : PubMed Abstract ESTHER: Lindblad-Toh_2011_Nature_478_476 PubMedSearch: Lindblad-Toh 2011 Nature 478 476 PubMedID: 21993624 Gene_locus related to this paper: cavpo-1plip ,
cavpo-2plrp ,
cavpo-h0v1b7 ,
cavpo-h0v5v8 ,
cavpo-h0vj36 ,
cavpo-lipli ,
rabit-1hlip ,
rabit-1plip ,
rabit-g1t6x7 ,
rabit-LIPH ,
myolu-l7n1c2 ,
myolu-g1pqd9 ,
cavpo-h0uyz6 ,
cavpo-h0vi56 ,
rabit-g1tbj4 ,
myolu-g1p5c0 ,
rabit-g1sds3 ,
rabit-g1sye0 ,
cavpo-h0v0r2 ,
cavpo-h0v7s5 ,
rabit-g1sp43 ,
myolu-g1p4p3 ,
cavpo-h0vw09 ,
rabit-g1ssu3 ,
myolu-g1pds0 ,
rabit-g1sic4 ,
cavpo-h0v2c4 ,
myolu-g1pg61 ,
myolu-g1pnb1 ,
myolu-g1pu06 ,
myolu-g1qa15 ,
myolu-g1qfu0 ,
rabit-g1sn99 ,
rabit-g1snq9 ,
rabit-g1sns7 ,
rabit-g1tuu8 ,
rabit-g1tzq7 ,
cavpo-h0v2i2 ,
cavpo-h0v2j0 ,
cavpo-h0vsf5 ,
cavpo-a0a286x8d3 ,
cavpo-a0a286xbr3 ,
cavpo-a0a286y0i8 ,
cavpo-a0a286y4p3 ,
myolu-g1q2n9 ,
cavpo-h0v1p4 ,
myolu-g1pan8 ,
myolu-g1paq0 ,
myolu-g1par4 ,
myolu-g1prn3 ,
myolu-g1q3i0 ,
myolu-g1q463 ,
myolu-g1pat6 ,
myolu-g1q859 ,
rabit-g1sul9 ,
rabit-g1sun0 ,
rabit-g1sup0 ,
myolu-l7n125 ,
myolu-g1pan2 ,
rabit-g1sxd0 ,
cavpo-h0v8j4 ,
rabit-d5fit0 ,
rabit-g1tkr5 ,
myolu-g1nty6 ,
myolu-g1p1p3 ,
cavpo-h0vdd5 ,
myolu-g1pdp2 ,
rabit-g1tmm5 ,
cavpo-h0vhq3 ,
myolu-g1nth4 ,
cavpo-h0vqx6 ,
rabit-g1tqr7 ,
myolu-g1p1e9 ,
cavpo-h0v8y6 ,
rabit-g1skt3 ,
myolu-g1nzg3 ,
cavpo-h0v5z0 ,
rabit-g1sgz5 ,
myolu-g1pkg5 ,
rabit-g1tmw5 ,
rabit-g1t134 ,
cavpo-a0a286x9v5 ,
myolu-g1qc57 ,
myolu-g1q061 ,
rabit-g1tnp4 ,
rabit-g1tyf7 ,
cavpo-h0w2w1 ,
rabit-g1ta36 ,
cavpo-h0w342 ,
myolu-g1q4e3 ,
rabit-g1sqa1 ,
cavpo-h0uxk7 ,
myolu-g1p353 ,
cavpo-h0vpm0 ,
rabit-a0a5f9cru6 ,
cavpo-a0a286xtc0 Abstract
The comparison of related genomes has emerged as a powerful lens for genome interpretation. Here we report the sequencing and comparative analysis of 29 eutherian genomes. We confirm that at least 5.5% of the human genome has undergone purifying selection, and locate constrained elements covering approximately 4.2% of the genome. We use evolutionary signatures and comparisons with experimental data sets to suggest candidate functions for approximately 60% of constrained bases. These elements reveal a small number of new coding exons, candidate stop codon readthrough events and over 10,000 regions of overlapping synonymous constraint within protein-coding exons. We find 220 candidate RNA structural families, and nearly a million elements overlapping potential promoter, enhancer and insulator regions. We report specific amino acid residues that have undergone positive selection, 280,000 non-coding elements exapted from mobile elements and more than 1,000 primate- and human-accelerated elements. Overlap with disease-associated variants indicates that our findings will be relevant for studies of human biology, health and disease.
Other Papers
Cavia porcellus (Guinea pig) phospolipase [PLRP2 like]