Gene_Locus Report

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Gene_locus Report for: colho-ACHE

Cochliomyia hominivorax (Primary screw-worm) Acetylcholinesterase

Comment
F466Y_colho-ACHE mutation found


Relationship
Family|ACHE
Block| C
Position in NCBI Life Tree|Cochliomyia hominivorax
(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)
> cellular organisms: N E > Eukaryota: N E > Opisthokonta: N E > Metazoa: N E > Eumetazoa: N E > Bilateria: N E > Protostomia: N E > Ecdysozoa: N E > Panarthropoda: N E > Arthropoda: N E > Mandibulata: N E > Pancrustacea: N E > Hexapoda: N E > Insecta: N E > Dicondylia: N E > Pterygota: N E > Neoptera: N E > Holometabola: N E > Diptera: N E > Brachycera: N E > Muscomorpha: N E > Eremoneura: N E > Cyclorrhapha: N E > Schizophora: N E > Calyptratae: N E > Oestroidea: N E > Calliphoridae: N E > Chrysomyinae: N E > Chrysomyini: N E > Cochliomyia: N E > Cochliomyia hominivorax: N E


Molecular evidence
Database
1 mutation: colho-ACHE
No structure
No kinetic





No Substrate
No inhibitor
1 Genbank : FJ830868
1 UniProt : D5FQ11
1 UniProt : D5FQ11
1 Interpro : D5FQ11
1 Prodom : D5FQ11
1 Pfam : D5FQ11
1 PIRSF : D5FQ11
1 SUPERFAM : D5FQ11
Sequence
Graphical view for this peptide sequence: colho-ACHE
Colored MSA for ACHE (raw)
MARFITSSSLSPSTTPSFASATASPAIASSLPRSKSTKATKARKTILSAN
SFKTSSLSSLSSSASSPSLSSSPSFFKSSSSSKSRYSSSHLFNAFASLIP
SSLAFSSLSFSSLTSTNDLYRGFFATLVILLRMSSVAYGITDRLIVQTTS
GPVRGRAVTVQGREVHVFTGIPYAKPPVDDLRFRKPVPAEPWHGVLDATR
LPATCVQERYEYFPGFSGEEIWNPNTNVSEDCLYMNIWAPSKARLRHGRG
ANGVEHAAKTDPDHLIHSATPQNTTNGLPILIWIYGGGFMTGSATLDIYN
ADIMSAVGNVIVASFQYRVGAFGFLHLSPVMPGFEEEAPGNVGLWDQALA
LRWLKENARAFGGNPEWMTLFGESAGSSSVNAQLVSPVTRGLVKRGMMQS
GTMNAPWSHMTSEKAVEIGKALINDCNCNASLLSENPQSVMACMRSVDAK
TISVQQWNSYSGILSFPSAPTIDGAFFTADPMTLMKTADMTGYDIMIGNV
KDEGTYFLLYDFIDYFDKDEATSLPRDKYLEIMNNIFNKATQAEREAIIF
QYTSWEGNPGYQNQQQIGRAVGDHFFTCPTNEYAQALAERGAQVHYYYFT
HRTSTSLWGEWMGVLHGDEIEYFFGQPLNTSLQYRPVERELGKRMLNSVI
EFAKTGNPAVDGEEWPNFSKEDPVYYVFSTDEKTEKLQRGPLAKRCSFWN
DYLPKVRSWVGSECENNNAASAAVNNINGQQYLLKWVIMLTIMVTCIFQ
Legend This sequence has been compared to family alignement (MSA)
red => minority aminoacid
blue => majority aminoacid
color intensity => conservation rate
title => sequence position(MSA position)aminoacid rate
Catalytic site
Catalytic site in the MSA

MARFITSSSLSPSTTPSFASATASPAIASSLPRSKSTKATKARKTILSAN
SFKTSSLSSLSSSASSPSLSSSPSFFKSSSSSKSRYSSSHLFNAFASLIP
SSLAFSSLSFSSLTSTNDLYRGFFATLVILLRMSSVAYGITDRLIVQTTS
GPVRGRAVTVQGREVHVFTGIPYAKPPVDDLRFRKPVPAEPWHGVLDATR
LPATCVQERYEYFPGFSGEEIWNPNTNVSEDCLYMNIWAPSKARLRHGRG
ANGVEHAAKTDPDHLIHSATPQNTTNGLPILIWIYGGGFMTGSATLDIYN
ADIMSAVGNVIVASFQYRVGAFGFLHLSPVMPGFEEEAPGNVGLWDQALA
LRWLKENARAFGGNPEWMTLFGESAGSSSVNAQLVSPVTRGLVKRGMMQS
GTMNAPWSHMTSEKAVEIGKALINDCNCNASLLSENPQSVMACMRSVDAK
TISVQQWNSYSGILSFPSAPTIDGAFFTADPMTLMKTADMTGYDIMIGNV
KDEGTYFLLYDFIDYFDKDEATSLPRDKYLEIMNNIFNKATQAEREAIIF
QYTSWEGNPGYQNQQQIGRAVGDHFFTCPTNEYAQALAERGAQVHYYYFT
HRTSTSLWGEWMGVLHGDEIEYFFGQPLNTSLQYRPVERELGKRMLNSVI
EFAKTGNPAVDGEEWPNFSKEDPVYYVFSTDEKTEKLQRGPLAKRCSFWN
DYLPKVRSWVGSECENNNAASAAVNNINGQQYLLKWVIMLTIMVTCIFQ


Reference
    Title: Acetylcholinesterase cDNA sequencing and identification of mutations associated with organophosphate resistance in Cochliomyia hominivorax (Diptera: Calliphoridae)
    da Silva NM, de Carvalho RA, de Azeredo-Espin AM
    Ref: Vet Parasitol, 177:190, 2011 : PubMed

            


Other Papers


Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
For technical information about these pages see:
ESTHER Home Page and ACEDB Home Page
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