Gene_Locus Report

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Gene_locus Report for: cultr-ACHE2

Culex tritaeniorhynchus Ace1 mRNA for acetylcholinesterase

Comment
Ace1 is close to the other insect acche2 and is named accordingly cultr-ACHE2


Relationship
Family|ACHE
Block| C
Position in NCBI Life Tree|Culex tritaeniorhynchus
(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)
> cellular organisms: N E > Eukaryota: N E > Opisthokonta: N E > Metazoa: N E > Eumetazoa: N E > Bilateria: N E > Protostomia: N E > Ecdysozoa: N E > Panarthropoda: N E > Arthropoda: N E > Mandibulata: N E > Pancrustacea: N E > Hexapoda: N E > Insecta: N E > Dicondylia: N E > Pterygota: N E > Neoptera: N E > Holometabola: N E > Diptera: N E > Nematocera: N E > Culicomorpha: N E > Culicoidea: N E > Culicidae: N E > Culicinae: N E > Culicini: N E > Culex [genus]: N E > Culex [subgenus]: N E > Culex tritaeniorhynchus: N E


Molecular evidence
Database
No mutation
No structure
No kinetic





No Substrate
No inhibitor
1 Genbank : AB122151
1 Ncbi-nid : 40363513
1 Ncbi-pid : 40363514
1 UniProt : Q75VY0
1 Interpro : Q75VY0
1 Prodom : Q75VY0
1 Pfam : Q75VY0
1 PIRSF : Q75VY0
1 SUPERFAM : Q75VY0
Sequence
Graphical view for this peptide sequence: cultr-ACHE2
Colored MSA for ACHE (raw)
MSSISMVVGILLCIAVISPVYGIFDRLVVQTSSGPIRGRSTMVQGREVHV
FNGVPFAKPPVDGLRFQKPVPAEPWHGVLDATRLPPSCIQERYEYFPGFA
GEEMWNPNTNVSEDCLYLNIWVPTKTRLRHGRGLNFGNNDYFQDDDDFQR
QHQSKGGLAMLVWIYGGGFMSGTSTLDVYNAEILAAVGNVIVASMQYRVG
AFGFFYLAPYLNGREEEAPGNVGLWDQALAIRWLKENAKAFGGDPDLITL
FGESAGGSSVSLHLLSPATRGLSHRGILQSGTLNAPWSHMTAEKALSVAE
SLIDDCNCNVTLLKDSPGSVMNCMRNVDAKTISVQQWNSYSGILGFPSAP
TIDGVFMTADPMTMLREANLEGIDILVGSNRDEGTYFLLYDFIDYFEKDA
ATSLPRDKFLEIMNTIFSKASEPEREAIIFQYTGWESGNDGYQNQQQVGR
AVGDHFFICPTNEFALGLTDRGASVHYYYFTHRTSTSLWGEWMGVLHGDE
VEYIFGQPMNATLQYRQRERDLSRRMVLSVSEFARSGNPALEGEHWPLYT
KENPIYFIFNAEGEDDLRGEKYGRGPMATSCAFWNDFLPRLRAWSIPPKP
SCNMLDQISAASVRYVDFKVVTVLTVLIVLRLF
Legend This sequence has been compared to family alignement (MSA)
red => minority aminoacid
blue => majority aminoacid
color intensity => conservation rate
title => sequence position(MSA position)aminoacid rate
Catalytic site
Catalytic site in the MSA

MSSISMVVGILLCIAVISPVYGIFDRLVVQTSSGPIRGRSTMVQGREVHV
FNGVPFAKPPVDGLRFQKPVPAEPWHGVLDATRLPPSCIQERYEYFPGFA
GEEMWNPNTNVSEDCLYLNIWVPTKTRLRHGRGLNFGNNDYFQDDDDFQR
QHQSKGGLAMLVWIYGGGFMSGTSTLDVYNAEILAAVGNVIVASMQYRVG
AFGFFYLAPYLNGREEEAPGNVGLWDQALAIRWLKENAKAFGGDPDLITL
FGESAGGSSVSLHLLSPATRGLSHRGILQSGTLNAPWSHMTAEKALSVAE
SLIDDCNCNVTLLKDSPGSVMNCMRNVDAKTISVQQWNSYSGILGFPSAP
TIDGVFMTADPMTMLREANLEGIDILVGSNRDEGTYFLLYDFIDYFEKDA
ATSLPRDKFLEIMNTIFSKASEPEREAIIFQYTGWESGNDGYQNQQQVGR
AVGDHFFICPTNEFALGLTDRGASVHYYYFTHRTSTSLWGEWMGVLHGDE
VEYIFGQPMNATLQYRQRERDLSRRMVLSVSEFARSGNPALEGEHWPLYT
KENPIYFIFNAEGEDDLRGEKYGRGPMATSCAFWNDFLPRLRAWSIPPKP
SCNMLDQISAASVRYVDFKVVTVLTVLIVLRLF


Reference
    Title: An amino acid substitution attributable to insecticide-insensitivity of acetylcholinesterase in a Japanese encephalitis vector mosquito, Culex tritaeniorhynchus
    Nabeshima T, Mori A, Kozaki T, Iwata Y, Hidoh O, Harada S, Kasai S, Severson DW, Kono Y, Tomita T
    Ref: Biochemical & Biophysical Research Communications, 313:794, 2004 : PubMed

            


Other Papers


Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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