Gene_locus Report for: danre-q6tgx0 Danio rerio (Zebrafish) (Brachydanio rerio) ndrg family member 3
Relationship
(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.) cellular organisms: N E > Eukaryota: N E > Opisthokonta: N E > Metazoa: N E > Eumetazoa: N E > Bilateria: N E > Deuterostomia: N E > Chordata: N E > Craniata: N E > Vertebrata: N E > Gnathostomata: N E > Teleostomi: N E > Euteleostomi: N E > Actinopterygii: N E > Actinopteri: N E > Neopterygii: N E > Teleostei: N E > Osteoglossocephalai: N E > Clupeocephala: N E > Otomorpha: N E > Ostariophysi: N E > Otophysi: N E > Cypriniphysae: N E > Cypriniformes: N E > Cyprinoidea: N E > Cyprinidae: N E > Danio: N E > Danio rerio: N E A85-EsteraseD-FGH :
danre-q567k2 Danio rerio (Zebrafish) (Brachydanio rerio) hypothetical protein zgc:111984 .
ABHD6-Lip :
danre-e7f881 Danio rerio (Zebrafish) (Brachydanio rerio) Uncharacterized protein ,
danre-e9qd39 Danio rerio (Zebrafish) (Brachydanio rerio) Abhydrolase domain-containing 6, acylglycerol lipase b .
ABHD8 :
danre-e7f070 Danio rerio (Zebrafish) (Brachydanio rerio). Abhydrolase domain-containing 8b .
ABHD10 :
danre-ABHD10a Danio rerio (Zebrafish) (Brachydanio rerio) Abhydrolase domain-containing 10a (abhd10) ,
danre-ABHD10b Danio rerio (Zebrafish) (Brachydanio rerio). Uncharacterized protein ABHD10b .
ABHD11-Acetyl_transferase :
danre-q6drd9 Danio rerio (Zebrafish) (Brachydanio rerio) ABHD11 wbscr21-like .
ABHD12-PHARC :
danre-q08c93 Danio rerio (Zebrafish) (Brachydanio rerio) abhydrolase domain containing 12 .
ABHD13-BEM46 :
danre-q32ls6 Danio rerio (Zebrafish) (Brachydanio rerio) Alpha/beta hydrolase domain-containing protein 13 zgc:123286 .
ABHD16 :
danre-a9jr90 Danio rerio (Zebrafish) (Brachydanio rerio). Bat5l protein .
ABHD17-depalmitoylase :
danre-Q7ZVZ7 Danio rerio (Zebrafish) (Brachydanio rerio) similar to riken cdna 2210412d01 gene .
ABHD18 :
danre-q5czu3 Danio rerio (Zebrafish) (Brachydanio rerio) Zgc:110741 ,
danre-f1q676 Danio rerio (Zebrafish) (Brachydanio rerio). Uncharacterized protein .
abh_upf0017 :
danre-abh2b Danio rerio (Zebrafish) (Brachydanio rerio) Abhydrolase domain-containing protein 2-B ,
danre-f1qq19 Danio rerio (Zebrafish) (Brachydanio rerio) Uncharacterized protein ,
danre-q66hu2 Danio rerio (Zebrafish) (Brachydanio rerio) zgc:92800 ,
danre-Q802V6 Danio rerio (Zebrafish) (Brachydanio rerio) similar to abhydrolase domain containing 2 ,
danre-e7fb35 Danio rerio (Zebrafish) (Brachydanio rerio). Abhydrolase domain-containing 15a .
ACHE :
danre-ACHE Danio rerio AChE gene for acetylcholinesterase, exons 1-4 .
Acidic_Lipase :
danre-1llip Danio rerio (Zebrafish) (Brachydanio rerio) lipf similar to lipase A, LIPH .
ACPH_Peptidase_S9 :
danre-q1rlp3 Danio rerio (Zebrafish) (Brachydanio rerio) zgc:136971 ,
danre-Q802D0 Danio rerio (Zebrafish) (Brachydanio rerio) similar to n-acylaminoacyl-peptide hydrolase (fragment) .
Acyl-CoA_Thioesterase :
danre-q5rh34 Danio rerio (Zebrafish) (Brachydanio rerio) similar to cytosolic Acyl-CoA amino acid n-acetyltransferase domain zgc:7765 ,
danre-q5rh35 Danio rerio (Zebrafish) (Brachydanio rerio) similar to cytosolic Acyl-CoA amino acid n-acetyltransferase domain ,
danre-q5rhg4 Danio rerio (Zebrafish) (Brachydanio rerio) similar to cytosolic Acyl-CoA amino acid n-acetyltransferase domain ,
danre-q5rhg5 Danio rerio (Zebrafish) (Brachydanio rerio) similar to cytosolic Acyl-CoA amino acid n-acetyltransferase domain ,
danre-q5spg7 Danio rerio (Zebrafish) (Brachydanio rerio) thioesterase. (fragment) ,
danre-q5spg8 Danio rerio (Zebrafish) (Brachydanio rerio) novel protein similar to vertebrate Acyl-CoA thioesterase family ,
danre-q5u3w6 Danio rerio (Zebrafish) (Brachydanio rerio) zgc:101553 ,
danre-q6gmj5 Danio rerio (Zebrafish) (Brachydanio rerio) hypothetical protein (fragment) ,
danre-q6ph28 Danio rerio (Zebrafish) (Brachydanio rerio) loc402867 CoA amino acid n-acetyltransferase domain (zgc:77651) (fragment) .
Arb2_FAM172A :
danre-f172a Danio rerio (Zebrafish) (Brachydanio rerio). Protein FAM172A .
Arylacetamide_deacetylase :
danre-q6dkf1 Danio rerio (Zebrafish) (Brachydanio rerio) zgc:92416 ,
danre-a0jme8 Danio rerio (Zebrafish) (Brachydanio rerio). Zgc:153038 ,
danre-e7ez27 Danio rerio (Zebrafish) (Brachydanio rerio). Uncharacterized protein ,
danre-e7f2w1 Danio rerio (Zebrafish) (Brachydanio rerio). Arylacetamide deacetylase ,
danre-f1qid7 Danio rerio (Zebrafish) (Brachydanio rerio). Arylacetamide deacetylase-like 4 .
Carboxypeptidase_S10 :
danre-CPMac Danio rerio (Zebrafish) (Brachydanio rerio) similar to carboxypeptidase, vitellogenic-like ,
danre-prtp Danio rerio (Zebrafish) (Brachydanio rerio) protective protein for beta-galactosidase ,
danre-RISC Danio rerio (Zebrafish) (Brachydanio rerio) similar to retinoid-inducible serine caroboxypetidase .
Carb_B_Chordata :
danre-a0a0r4iu19.1 Danio rerio (Zebrafish) (Brachydanio rerio) Carboxylesterase 2b fragment n-term ,
danre-5cxest Danio rerio cDNA clone IMAGE:7042549, partial cds ,
danre-a9jrf7 Danio rerio (Zebrafish) (Brachydanio rerio) Si:ch211-93f2.1 protein ,
danre-e7ezq9 Danio rerio (Zebrafish) (Brachydanio rerio) Uncharacterized protein ,
danre-q5bji3 Danio rerio (Zebrafish) (Brachydanio rerio) hypothetical protein (fragment) .
CGI-58_ABHD5_ABHD4 :
danre-q568j2 Danio rerio (Zebrafish) (Brachydanio rerio) hypothetical protein zgc:110267 .
Cholesterol_esterase :
danre-2balip Danio rerio (Zebrafish) (Brachydanio rerio) hypothetical protein ,
danre-q4qrh4 Danio rerio (Zebrafish) (Brachydanio rerio) hypothetical protein zgc:112377 ,
danre-Q6P004 Danio rerio (Zebrafish) (Brachydanio rerio) hypothetical cel.2 protein (fragment) (fragment) .
Cholinesterase-like :
danre-ACHEE Danio rerio (Zebrafish) (Brachydanio rerio) hypothetical protein ,
danre-e7ff77 Danio rerio (Zebrafish) (Brachydanio rerio) Uncharacterized protein .
CIB-CCG1-interacting-factor-B :
danre-AAH53212 Danio rerio (Zebrafish) (Brachydanio rerio) hypothetical protein ,
danre-abhea Danio rerio (Zebrafish) (Brachydanio rerio) Abhydrolase domain-containing protein 14A .
CMBL :
danre-a7mbu9 Danio rerio (Zebrafish) (Brachydanio rerio). Zgc:171683 protein .
DPP4N_Peptidase_S9 :
danre-b0r1c4 Danio rerio (Zebrafish) (Brachydanio rerio) Si:dkey-81j5.3 ,
danre-b5ddz4 Danio rerio (Zebrafish) (Brachydanio rerio) Novel protein similar to H.sapiens DPP4, dipeptidyl-peptidase 4 (DPP4) ,
danre-e7f5r8 Danio rerio (Zebrafish) (Brachydanio rerio) Dipeptidyl-peptidase 6b ,
danre-q08br3 Danio rerio (Zebrafish) (Brachydanio rerio) Zgc:152900 .
Duf_829 :
danre-a3kpm9 Danio rerio (Zebrafish) (Brachydanio rerio) Novel protein ,
danre-tmm53 Danio rerio (Zebrafish) (Brachydanio rerio) Transmembrane protein 53 .
Epoxide_hydrolase :
danre-ephx1l Danio rerio (Zebrafish) (Brachydanio rerio) hypothetical protein (fragment) ,
danre-hyep Danio rerio (Zebrafish) (Brachydanio rerio) similar to epoxide hydrolase 1, microsomal (xenobiotic) Zgc:56126 OTTDARG00000005675 ,
danre-q5prc6 Danio rerio (Zebrafish) (Brachydanio rerio) zgc:101645 .
FSH1 :
danre-OVCA2 Danio rerio (Zebrafish) (Brachydanio rerio) hypothetical protein zgc:110011 .
Hepatic_Lipase :
danre-q7t359 Danio rerio (Zebrafish) (Brachydanio rerio) similar to lipase, hepatic .
Kynurenine-formamidase :
danre-afmid Danio rerio (Zebrafish) (Brachydanio rerio) Kynurenine formamidase .
LIDHydrolase :
danre-b3dii8 Danio rerio (Zebrafish) (Brachydanio rerio) Zgc:195062 .
Lipoprotein_Lipase :
danre-q6p2u2 Danio rerio (Zebrafish) (Brachydanio rerio) lipoprotein lipase ,
danre-Q803Y3 Danio rerio (Zebrafish) (Brachydanio rerio) similar to lipase, endothelial ,
danre-a0a0g2kru2 Danio rerio (Zebrafish) (Brachydanio rerio). Uncharacterized protein ,
danre-f1qla7 Danio rerio (Zebrafish) (Brachydanio rerio). Uncharacterized protein .
LYsophospholipase_carboxylesterase :
danre-q5czm6 Danio rerio (Zebrafish) (Brachydanio rerio) hypothetical protein zgc:110848 ,
danre-q6pbw8 Danio rerio (Zebrafish) (Brachydanio rerio) hypothetical protein zgc:73210 .
Maspardin-ACP33-SPG21_like :
danre-SPG21 Danio rerio clone RK047A3F07 acid cluster protein 33, SPG21, Maspardin mRNA, complete .
MEST-like :
danre-PEG1 Danio rerio (Zebrafish) (Zebra danio) epoxide hydrolase (EC 3.3.2.3)mesoderm specific transcript .
Monoglyceridelipase_lysophospholip :
danre-Q7ZWC2 Danio rerio (Zebrafish) (Brachydanio rerio) Monoglyceridelipase_lysophospholipase hypothetical protein .
Ndr_family :
danre-ndr3 Danio rerio (Zebrafish) (Brachydanio rerio) (Brachydanio rerio) similar to n-myc downstream regulated 3 ,
danre-ndrg2 Danio rerio (Zebrafish) (Brachydanio rerio) (ndgr2) zgc:101847 ,
danre-q1mti5 Danio rerio (Zebrafish) (Brachydanio rerio) novel protein similar to vertebrate ndrg family member 4 (ndrg4) ,
danre-q6a3p5 Danio rerio (Zebrafish) (Brachydanio rerio) n-myc downstream regulated gene 1 protein, ndrg1 zgc:63944 ,
danre-q6pc94 Danio rerio (Zebrafish) (Brachydanio rerio) n-myc downstream regulated gene 1, like .
Neuroligin :
danre-1neur Danio rerio (Zebrafish) (Brachydanio rerio) Neuroligin 1 ,
danre-32neur Danio rerio (Zebrafish) (Brachydanio rerio) novel protein similar to vertebrate neuroligin 3 (nlgn3) (fragment) ,
danre-d2x2g1 Danio rerio (Zebrafish) (Brachydanio rerio) Neuroligin 2 ,
danre-d2x2g3 Danio rerio (Zebrafish) (Brachydanio rerio) Neuroligin 3 ,
danre-d2x2g5 Danio rerio (Zebrafish) (Brachydanio rerio) Neuroligin 4b ,
danre-nlgn2a Danio rerio (Zebrafish) (Brachydanio rerio) Neuroligin 2a ,
danre-nlgn4a Danio rerio (Zebrafish) (Brachydanio rerio) Neuroligin 4a .
NLS3-Tex30 :
danre-kanl3 Danio rerio (Zebrafish) (Brachydanio rerio) Non-specific lethal 3 homolog, KIAA1310 homolog ,
danre-tex30 Danio rerio (Zebrafish) (Brachydanio rerio) Uncharacterized protein .
PAF-Acetylhydrolase :
danre-q6nyi7 Danio rerio (Zebrafish) (Brachydanio rerio) zgc:77563 (platelet-activating factor acetylhydrolase, plasma (pla2g7) .
Palmitoyl-protein_thioesterase :
danre-PPT2 Danio rerio (Zebrafish) (Brachydanio rerio) similar to palmitoyl-protein thioesterase 2 ,
danre-q4v960 Danio rerio (Zebrafish) (Brachydanio rerio) hypothetical protein zgc:113969 ,
danre-q6nxd0 Danio rerio (Zebrafish) (Brachydanio rerio) hypothetical protein zgc:77118 ,
danre-q6pd98 Danio rerio (Zebrafish) (Brachydanio rerio) hypothetical protein zgc:66024 ,
danre-q7t3c4 Danio rerio (Zebrafish) (Brachydanio rerio) palmitoyl-protein thioesterase .
PC-sterol_acyltransferase :
danre-q6nyh6 Danio rerio (Zebrafish) (Brachydanio rerio) hypothetical protein pla2g15 .
Pectinacetylesterase-Notum :
danre-c5h5c4 Danio rerio (Zebrafish) (Brachydanio rerio) Notum3 ,
danre-e7f0z8 Danio rerio (Zebrafish) (Brachydanio rerio). Uncharacterized protein .
PGAP1 :
danre-srac1 Danio rerio (Zebrafish) (Brachydanio rerio) Protein SERAC1 .
Phospholipase :
danre-LIPH Danio rerio (Zebrafish) (Brachydanio rerio) zgc:91985 ,
danre-q6nyz4 Danio rerio (Zebrafish) (Brachydanio rerio) hypothetical protein zgc:77160 ,
danre-f1qtr2 Danio rerio (Zebrafish) (Brachydanio rerio). Lipase, member Ib .
PPase_methylesterase_euk :
danre-Q7ZV37 Danio rerio (Zebrafish) (Brachydanio rerio) similar to protein phosphatase methylesterase-1 .
Prolylcarboxypeptidase :
danre-f1q7g9 Danio rerio (Zebrafish) (Brachydanio rerio) Uncharacterized protein ,
danre-q5czt1 Danio rerio (Zebrafish) (Brachydanio rerio) zgc:113564 ,
danre-q6dg46 Danio rerio (Zebrafish) (Brachydanio rerio) zgc:91816 .
S9N_PPCE_Peptidase_S9 :
danre-q503e2 Danio rerio (Zebrafish) (Brachydanio rerio) hypothetical protein zgc:110670 .
SERHL :
danre-A2BGU9 Danio rerio (Zebrafish) (Brachydanio rerio) similar to kraken-like zgc:55804 .
Thioesterase :
danre-q29r98 Danio rerio (Zebrafish) (Brachydanio rerio) zgc:136926 .
Thyroglobulin :
danre-f1qfr0 Danio rerio (Zebrafish) (Brachydanio rerio) Uncharacterized protein .
Valacyclovir-hydrolase :
danre-h9gyq0 Danio rerio (Zebrafish) (Brachydanio rerio) Biphenyl hydrolase like ,
danre-Q7ZVE1 Danio rerio (Zebrafish) (Brachydanio rerio) similar to biphenyl hydrolase-like Molecular evidence
Database
No mutation No structure No kinetic No Substrate No inhibitor
Sequence
Graphical view for this peptide sequence: danre-q6tgx0 Colored MSA for Ndr_family (raw)
MDELQDVQLTEIKPLLTYKNSQNFQDFDCQEHDIETPHGVLHVTMRGSPK
GNRPVILTYHDIGLNHKSCFNTLFNFEDMMEITQHFAVVHVDAPGQQEGG
PPFPTGYLYPTMDELAEMLPSVLTQLKVNSVIGIGVGAGAYILTRFALIH
PSLVEGLVLINVDPCAEGWIDWAASKLTGWTSNLVDIVMAHHFSTEELTD
NQELIQTYRLHIAQDINQDNLALFCGSYNARQDLGIERPIAGLNENIVKT
LTCPALLVVGDTSPAVEAVVECNSRLNPTKTTLLKMADCGGLPQVVQPGK
LAEAFKYFVQGMGYIPAAGMTRLSRSRSSSSSITSTDGSRNRNLNSPLDG
PQFWTTNHGGVLLKLKCPPATAV
Legend
This sequence has been compared to family alignement (MSA) red => minority aminoacid blue => majority aminoacid color intensity => conservation rate title => sequence position(MSA position)aminoacid rate Catalytic site Catalytic site in the MSA
M D E L Q D V Q L T E I K P L L T Y K N S Q N F Q D F D C Q E H D I E T P H G V L H V T M R G S P K G N R P V I L T Y H D I G L N H K S C F N T L F N F E D M M E I T Q H F A V V H V D A P G Q Q E G G P P F P T G Y L Y P T M D E L A E M L P S V L T Q L K V N S V I G I G V G A G A Y I L T R F A L I H P S L V E G L V L I N V D P C A E G W I D W A A S K L T G W T S N L V D I V M A H H F S T E E L T D N Q E L I Q T Y R L H I A Q D I N Q D N L A L F C G S Y N A R Q D L G I E R P I A G L N E N I V K T L T C P A L L V V G D T S P A V E A V V E C N S R L N P T K T T L L K M A D C G G L P Q V V Q P G K L A E A F K Y F V Q G M G Y I P A A G M T R L S R S R S S S S S I T S T D G S R N R N L N S P L D G P Q F W T T N H G G V L L K L K C P P A T A V
Reference
Title: Hematopoietic gene expression profile in zebrafish kidney marrowSong HD , Sun XJ , Deng M , Zhang GW , Zhou Y , Wu XY , Sheng Y , Chen Y , Ruan Z and Chen Z <6 more author(s)> Song HD , Sun XJ , Deng M , Zhang GW , Zhou Y , Wu XY , Sheng Y , Chen Y , Ruan Z , Jiang CL , Fan HY , Zon LI , Kanki JP , Liu TX , Look AT , Chen Z (- 6) Ref: Proc Natl Acad Sci U S A, 101 :16240, 2004 : PubMed Abstract ESTHER: Song_2004_Proc.Natl.Acad.Sci.U.S.A_101_16240 PubMedSearch: Song 2004 Proc.Natl.Acad.Sci.U.S.A 101 16240 PubMedID: 15520368 Gene_locus related to this paper: danre-q6tgx0 ,
danre-Q7ZWC2 ,
danre-SPG21 Abstract
The zebrafish kidney marrow is considered to be the organ of definitive hematopoiesis, analogous to the mammalian bone marrow. We have sequenced 26,143 ESTs and isolated 304 cDNAs with putative full-length ORF from a zebrafish kidney marrow cDNA library. The ESTs formed 7,742 assemblies, representing both previously identified zebrafish ESTs (56%) and recently discovered zebrafish ESTs (44%). About 30% of these EST assemblies have orthologues in humans, including 1,282 disease-associated genes in the Online Mendelian Inheritance in Man (OMIM) database. Comparison of the effective and regulatory molecules related to erythroid functions across species suggests a good conservation from zebrafish to human. Interestingly, both embryonic and adult zebrafish globin genes showed higher homology to the human embryonic globin genes than to the human fetal/adult ones, consistent with evo-devo correlation hypothesis. In addition, conservation of a whole set of transcription factors involved in globin gene switch suggests the regulatory network for such remodeling mechanism existed before the divergence of the teleost and the ancestor of mammals. We also carried out whole-mount mRNA in situ hybridization assays for 493 cDNAs and identified 80 genes (16%) with tissue-specific expression during the first five days of zebrafish development. Twenty-six of these genes were specifically expressed in hematopoietic or vascular tissues, including three previously unidentified zebrafish genes: coro1a, nephrosin, and dab2. Our results indicate that conserved genetic programs regulate vertebrate hematopoiesis and vasculogenesis, and support the role of the zebrafish as an important animal model for studying both normal development and the molecular pathogenesis of human blood diseases.
Other Papers
