drome-CG12869

 
Drosophila melanogaster (Fruit fly) CG12869 gene for a carboxylesterase may be inactive

Comment
Nucleotide sequence from Celera. Active serine in GHGSGG


Relationship
Block C
Drosophila melanogaster position in NCBI Life Tree :
N link to NCBI taxonomic web page and E link to ESTHER gene locus found in this strain.
> cellular organisms: N E > Eukaryota: N E > Opisthokonta: N E > Metazoa: N E > Eumetazoa: N E > Bilateria: N E > Protostomia: N E > Ecdysozoa: N E > Panarthropoda: N E > Arthropoda: N E > Mandibulata: N E > Pancrustacea: N E > Hexapoda: N E > Insecta: N E > Dicondylia: N E > Pterygota: N E > Neoptera: N E > Holometabola: N E > Diptera: N E > Brachycera: N E > Muscomorpha: N E > Eremoneura: N E > Cyclorrhapha: N E > Schizophora: N E > Acalyptratae: N E > Ephydroidea: N E > Drosophilidae: N E > Drosophilinae: N E > Drosophilini: N E > Drosophila [fruit fly, genus]: N E > Sophophora: N E > melanogaster group: N E > melanogaster subgroup: N E > Drosophila melanogaster: N E

Molecular evidence
Database
No mutation
No structure
No kinetic



>3 Genbank links 1 more: AE003671, AE003814, NM_137125
1 Ncbi-nid : 19922253
2 Ncbi-pid : 19922254, 7303171
1 UniProtTrembl : Q8T016
1 Interpro : Q8T016
1 Prodom : Q8T016
1 Pfam : Q8T016
1 PIRSF : Q8T016
1 SUPERFAM : Q8T016
1 QuickSwissBlast : Q8T016
1 EntrezGene : 36616
1 SNP : 36616
1 FlyBase : 0033943
 
Sequence
Graphical view for this peptide sequence: drome-CG12869
Colored MSA for OtherNon-catalytic_C (raw)
MWNALRIQQILRLLPILIHLSPYISAQQTHIKLEQGDLIGLKVFPDGTRG
AVYAFLGIPYAQAPINELRFAPAKPSSSFNRTLQATTMQPLCPQLANTIY
DESSDGSMPRSVSTDEDCLYLNIWTPESGMRYGKLPIVVIVTGEEFAYDW
PRNRINGLDLAGEGIVVVSVQYRNNIYGWLSLGEQHRNVPGNYGLSDVQM
ALRWIRRNADAFGGNPDHITLLGHGSGGAPLALVATLEDSSQVKQLVLMS
PGPIMRALGQNHQKWIVETGQVLVQKLGCQFEEAQRRQLMGCLRRKSRED
LLRAYESVYNHGNGSSQLGVILPEGLPLEQRLRNKTLPPVLLGITSNEGA
FLQDYWLDVAREGQVALHKYINHTLLPNVMRALESVGEESSTQLAAIRWR
YFNGKGEGVSHLLAGMQRLLSESLYELPYSRILELLNGTTSYAYVFDHSH
SMDMRGRRNLFGGASHSSDLPLLLGPSLFQQIARRRFSGEEEQLCRKIRG
AFANFIKNGNPTPGRIYDGWLPYNKENPFVYSLGEQAKTPQTGSVDEAEV
DKLLRGETGAPGLDRSLSRSNRHDTYRAAPSNSYTASNQLDSGYSNHLQM
VYGFWQVLMPLEREEDLRGGGALGQRVRLLEASADAARYRQGFYAMLGLW
FRWTTIFGGRKDEVPSTSGIANVESWRKGGRATKREQDGSGAVESGGGDG
NLEGERREQVLNKQRTRRPRQLQPYDFKITHPIGGAGVGAGFGTGTAGGV
RNGGGTRAGTVSGFGGTLGTVEELLDPVAGQFEPSVAVRNWQYQLTCDKF
Legend This sequence has been compared to family alignement (MSA)
red => minority aminoacid
blue => majority aminoacid
color intensity => conservation rate
title => sequence position(MSA position)aminoacid rate
Catalytic site
Catalytic site in the MSA

MWNALRIQQILRLLPILIHLSPYISAQQTHIKLEQGDLIGLKVFPDGTRG
AVYAFLGIPYAQAPINELRFAPAKPSSSFNRTLQATTMQPLCPQLANTIY
DESSDGSMPRSVSTDEDCLYLNIWTPESGMRYGKLPIVVIVTGEEFAYDW
PRNRINGLDLAGEGIVVVSVQYRNNIYGWLSLGEQHRNVPGNYGLSDVQM
ALRWIRRNADAFGGNPDHITLLGHGSGGAPLALVATLEDSSQVKQLVLMS
PGPIMRALGQNHQKWIVETGQVLVQKLGCQFEEAQRRQLMGCLRRKSRED
LLRAYESVYNHGNGSSQLGVILPEGLPLEQRLRNKTLPPVLLGITSNEGA
FLQDYWLDVAREGQVALHKYINHTLLPNVMRALESVGEESSTQLAAIRWR
YFNGKGEGVSHLLAGMQRLLSESLYELPYSRILELLNGTTSYAYVFDHSH
SMDMRGRRNLFGGASHSSDLPLLLGPSLFQQIARRRFSGEEEQLCRKIRG
AFANFIKNGNPTPGRIYDGWLPYNKENPFVYSLGEQAKTPQTGSVDEAEV
DKLLRGETGAPGLDRSLSRSNRHDTYRAAPSNSYTASNQLDSGYSNHLQM
VYGFWQVLMPLEREEDLRGGGALGQRVRLLEASADAARYRQGFYAMLGLW
FRWTTIFGGRKDEVPSTSGIANVESWRKGGRATKREQDGSGAVESGGGDG
NLEGERREQVLNKQRTRRPRQLQPYDFKITHPIGGAGVGAGFGTGTAGGV
RNGGGTRAGTVSGFGGTLGTVEELLDPVAGQFEPSVAVRNWQYQLTCDKF

no DNA




Reference
    Title: The genome sequence of Drosophila melanogaster
    Adams MD, Celniker SE, Holt RA, Evans CA, Gocayne JD, Amanatides PG, Scherer SE, Li PW, Hoskins RA and Venter JC <185 more author(s)>
    Ref: Science, 287:2185, 2000 : PubMed

            


Other Papers


Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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