Gene_Locus Report

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Gene_locus Report for: drome-CG15102

Drosophila melanogaster (Fruit fly) JHEH2 epoxide hydrolase (EC 3.3.2.3)

Relationship
Family|Epoxide_hydrolase
Block| X
Position in NCBI Life Tree|Drosophila melanogaster
(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)
> cellular organisms: N E > Eukaryota: N E > Opisthokonta: N E > Metazoa: N E > Eumetazoa: N E > Bilateria: N E > Protostomia: N E > Ecdysozoa: N E > Panarthropoda: N E > Arthropoda: N E > Mandibulata: N E > Pancrustacea: N E > Hexapoda: N E > Insecta: N E > Dicondylia: N E > Pterygota: N E > Neoptera: N E > Holometabola: N E > Diptera: N E > Brachycera: N E > Muscomorpha: N E > Eremoneura: N E > Cyclorrhapha: N E > Schizophora: N E > Acalyptratae: N E > Ephydroidea: N E > Drosophilidae: N E > Drosophilinae: N E > Drosophilini: N E > Drosophila [fruit fly, genus]: N E > Sophophora: N E > melanogaster group: N E > melanogaster subgroup: N E > Drosophila melanogaster: N E


Molecular evidence
Database
No mutation
No structure
No kinetic





1 substrate:
Cis-stilbene-oxide
No inhibitor
>3 Genbank links 1 more: AE003798, AY070647, AAM88328
2 UniProt : Q8SZM7, Q7KB18
2 Interpro : Q8SZM7, Q7KB18
2 Prodom : Q8SZM7, Q7KB18
2 Pfam : Q8SZM7, Q7KB18
2 PIRSF : Q8SZM7, Q7KB18
2 SUPERFAM : Q8SZM7, Q7KB18
1 FlyBase : 0034405
Sequence
Graphical view for this peptide sequence: drome-CG15102
Colored MSA for Epoxide_hydrolase (raw)
MANIWPRILVGALTILVAVGYKNYRDLSAPGKRPDLDNNAYWGPTLKEPY
RENKAILPFDISVKPEVIEDLIGQLSRPLKAQAPLEGVGFQYGFNANELA
KVVKYWRDTYLPKWSEREEYLKKLDHYQTEIQGLKIHFIHAKPSQVKGQK
PKKVLPLLLMHGWPGTVREFYDFIPLLTTPSDKSDYVFEVIAPSLPGYGW
SQGSSKTGFGVAQVAVVMRNLMLRVGFDKFLVQGGDWGSIIGSNVASLFP
ENVLGYHSNMCGNNSPMGQLKMVLASFFPSWFVDSEYADFYKGLGHLFST
IMEEMGYAHIQASKPDTIGNALIDNPTGLASYILEKFSTWTNTAFRSLPD
GGLTKRFTYDQLLDNVMIYYVTNSITTSMRLYSESMVASQFALAVDSVPI
KAKAGCTRFAHEITHFSDSVLANKFPNLVHSTHHRDGGHFPAFELPQQLY
DDFVSFVQKANFS
Legend This sequence has been compared to family alignement (MSA)
red => minority aminoacid
blue => majority aminoacid
color intensity => conservation rate
title => sequence position(MSA position)aminoacid rate
Catalytic site
Catalytic site in the MSA

MANIWPRILVGALTILVAVGYKNYRDLSAPGKRPDLDNNAYWGPTLKEPY
RENKAILPFDISVKPEVIEDLIGQLSRPLKAQAPLEGVGFQYGFNANELA
KVVKYWRDTYLPKWSEREEYLKKLDHYQTEIQGLKIHFIHAKPSQVKGQK
PKKVLPLLLMHGWPGTVREFYDFIPLLTTPSDKSDYVFEVIAPSLPGYGW
SQGSSKTGFGVAQVAVVMRNLMLRVGFDKFLVQGGDWGSIIGSNVASLFP
ENVLGYHSNMCGNNSPMGQLKMVLASFFPSWFVDSEYADFYKGLGHLFST
IMEEMGYAHIQASKPDTIGNALIDNPTGLASYILEKFSTWTNTAFRSLPD
GGLTKRFTYDQLLDNVMIYYVTNSITTSMRLYSESMVASQFALAVDSVPI
KAKAGCTRFAHEITHFSDSVLANKFPNLVHSTHHRDGGHFPAFELPQQLY
DDFVSFVQKANFS


References
    Title: Cloning and Characterization of Drosophila melanogaster Juvenile Hormone Epoxide Hydrolases (JHEH) and Their Promoters
    Borovsky D, Breyssens H, Buytaert E, Peeters T, Laroye C, Stoffels K, Rouge P
    Ref: Biomolecules, 12:991, 2022 : PubMed

            

    Title: Characterization and cDNA cloning of a clofibrate-inducible microsomal epoxide hydrolase in Drosophila melanogaster
    Taniai K, Inceoglu AB, Yukuhiro K, Hammock BD
    Ref: European Journal of Biochemistry, 270:4696, 2003 : PubMed

            

    Title: The genome sequence of Drosophila melanogaster
    Adams MD, Celniker SE, Holt RA, Evans CA, Gocayne JD, Amanatides PG, Scherer SE, Li PW, Hoskins RA and Venter JC <185 more author(s)>
    Ref: Science, 287:2185, 2000 : PubMed

            


Other Papers


Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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