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drome-CG8425

Drosophila melanogaster (Fruit fly) CG8425 juvenile hormone esterase

Comment

Q3ZAK4 difference part missing in the middle of the sequence || Annotation from Dr Peter Campbell : There is an error in the sequence as predicted by the genome project which they should correct soon. The sixth predicted intron is not removed\; instead there is a stop codon and poly A site. This makes the protein the usual length for an esterase rather than 50\% too long. CG8425 DmJHEdup appears to be a duplication of CG8424. CG8424 is a juvenile hormone esterase. DmJHE is the hormone esterase with precise regulation and highly specific activity for its substrate, juvenile hormone. DmJHEdup is an odorant degrading esterase (ODE) responsible for processing various kairomones in antennae

Relationship

Family : Juvenile_hormone_esterase

Block : C

Position in NCBI Life Tree : Drosophila melanogaster

Molecular evidence

No mutation

No structure

No kinetic

No disease

No substrate

Database

Sequence

Peptide

MLQLLLLGQL LAGPGPFCAA LATVDQLTVC PPSVGCLKGT NLQGYQSERF EAFMGIPYAL PPIGDLRFSN PKVMPKLLGM YDASAPKMDC IQKNYLLPTP VVYGDEDCLY LNVYRPEIRK SALPVMVYIH GGGFFGGSAG PGVTGPEYFM DSGEVILVTM AYRLGPFGFL STQDAVMSGN FGLKDQNLAL RWVQRNIRFF GGDPQRVTIF GQSAGGVAAH MHLLSPRSHG LFHRVISMSG TANVPFAIAE QPLEQARLLA EFADVPDARN LSTVKLTKAL RRINATKLLN AGDGLKYWDV DHMTNFRPVV EEGLEVDAFL NAHPMDMLAQ GMPTSIPLLL GTVPGEGAVR VVNILGNETL RQSFNLRFDE LLQELLEFPA SFSQDRREKM MDLLVEVYFQ GQHEVNELTV QGFMNLISDR GFKQPLYNTI HKNVCHTPNP VYLYSFNYQG PLSYASAYTS ANVTGKYGVV HCDDLLYLFR SPLLFPDFQR NSTEAKVIHS FVDYFVHFAK FGKPRNSVLL TPCSIEVLQS RPDGICDYHE FANAPDAYQG FEVHVASEFQ TDRVNWSHIL NEK

References

Title : The molecular basis for the neofunctionalization of the juvenile hormone esterase duplication in Drosophila - Hopkins_2019_Insect.Biochem.Mol.Biol_106_10
Author(s) : Hopkins DH , Rane RV , Younus F , Coppin CW , Pandey G , Jackson CJ , Oakeshott JG
Ref : Insect Biochemistry & Molecular Biology , 106 :10 , 2019
Abstract : Hopkins_2019_Insect.Biochem.Mol.Biol_106_10
ESTHER : Hopkins_2019_Insect.Biochem.Mol.Biol_106_10
PubMedSearch : Hopkins_2019_Insect.Biochem.Mol.Biol_106_10
PubMedID: 30611903
Gene_locus related to this paper: drome-CG8424 , drome-CG8425

Title : Functional fat body proteomics and gene targeting reveal in vivo functions of Drosophila melanogaster a-Esterase-7 - Birner-Gruenberger_2012_Insect.Biochem.Mol.Biol_42_220
Author(s) : Birner-Gruenberger R , Bickmeyer I , Lange J , Hehlert P , Hermetter A , Kollroser M , Rechberger GN , Kuhnlein RP
Ref : Insect Biochemistry & Molecular Biology , 42 :220 , 2012
Abstract : Birner-Gruenberger_2012_Insect.Biochem.Mol.Biol_42_220
ESTHER : Birner-Gruenberger_2012_Insect.Biochem.Mol.Biol_42_220
PubMedSearch : Birner-Gruenberger_2012_Insect.Biochem.Mol.Biol_42_220
PubMedID: 22198472
Gene_locus related to this paper: drome-aes02 , drome-aes05 , drome-CG1882 , drome-CG2059 , drome-CG5355 , drome-CG8425 , drome-CG18815 , drome-EST23aes07 , drome-este6

Title : Identification of a juvenile hormone esterase gene by matching its peptide mass fingerprint with a sequence from the Drosophila genome project - Campbell_2001_Insect.Biochem.Mol.Biol_31_513
Author(s) : Campbell PM , Harcourt RL , Crone EJ , Claudianos C , Hammock BD , Russell RJ , Oakeshott JG
Ref : Insect Biochemistry & Molecular Biology , 31 :513 , 2001
Abstract : Campbell_2001_Insect.Biochem.Mol.Biol_31_513
ESTHER : Campbell_2001_Insect.Biochem.Mol.Biol_31_513
PubMedSearch : Campbell_2001_Insect.Biochem.Mol.Biol_31_513
PubMedID: 11267890
Gene_locus related to this paper: drome-CG8424 , drome-CG8425

Title : The genome sequence of Drosophila melanogaster - Adams_2000_Science_287_2185
Author(s) : Adams MD , Celniker SE , Holt RA , Evans CA , Gocayne JD , Amanatides PG , Scherer SE , Li PW , Hoskins RA , Galle RF , George RA , Lewis SE , Richards S , Ashburner M , Henderson SN , Sutton GG , Wortman JR , Yandell MD , Zhang Q , Chen LX , Brandon RC , Rogers YH , Blazej RG , Champe M , Pfeiffer BD , Wan KH , Doyle C , Baxter EG , Helt G , Nelson CR , Gabor GL , Abril JF , Agbayani A , An HJ , Andrews-Pfannkoch C , Baldwin D , Ballew RM , Basu A , Baxendale J , Bayraktaroglu L , Beasley EM , Beeson KY , Benos PV , Berman BP , Bhandari D , Bolshakov S , Borkova D , Botchan MR , Bouck J , Brokstein P , Brottier P , Burtis KC , Busam DA , Butler H , Cadieu E , Center A , Chandra I , Cherry JM , Cawley S , Dahlke C , Davenport LB , Davies P , de Pablos B , Delcher A , Deng Z , Mays AD , Dew I , Dietz SM , Dodson K , Doup LE , Downes M , Dugan-Rocha S , Dunkov BC , Dunn P , Durbin KJ , Evangelista CC , Ferraz C , Ferriera S , Fleischmann W , Fosler C , Gabrielian AE , Garg NS , Gelbart WM , Glasser K , Glodek A , Gong F , Gorrell JH , Gu Z , Guan P , Harris M , Harris NL , Harvey D , Heiman TJ , Hernandez JR , Houck J , Hostin D , Houston KA , Howland TJ , Wei MH , Ibegwam C , Jalali M , Kalush F , Karpen GH , Ke Z , Kennison JA , Ketchum KA , Kimmel BE , Kodira CD , Kraft C , Kravitz S , Kulp D , Lai Z , Lasko P , Lei Y , Levitsky AA , Li J , Li Z , Liang Y , Lin X , Liu X , Mattei B , McIntosh TC , McLeod MP , McPherson D , Merkulov G , Milshina NV , Mobarry C , Morris J , Moshrefi A , Mount SM , Moy M , Murphy B , Murphy L , Muzny DM , Nelson DL , Nelson DR , Nelson KA , Nixon K , Nusskern DR , Pacleb JM , Palazzolo M , Pittman GS , Pan S , Pollard J , Puri V , Reese MG , Reinert K , Remington K , Saunders RD , Scheeler F , Shen H , Shue BC , Siden-Kiamos I , Simpson M , Skupski MP , Smith T , Spier E , Spradling AC , Stapleton M , Strong R , Sun E , Svirskas R , Tector C , Turner R , Venter E , Wang AH , Wang X , Wang ZY , Wassarman DA , Weinstock GM , Weissenbach J , Williams SM , WoodageT , Worley KC , Wu D , Yang S , Yao QA , Ye J , Yeh RF , Zaveri JS , Zhan M , Zhang G , Zhao Q , Zheng L , Zheng XH , Zhong FN , Zhong W , Zhou X , Zhu S , Zhu X , Smith HO , Gibbs RA , Myers EW , Rubin GM , Venter JC
Ref : Science , 287 :2185 , 2000
Abstract : Adams_2000_Science_287_2185
ESTHER : Adams_2000_Science_287_2185
PubMedSearch : Adams_2000_Science_287_2185
PubMedID: 10731132
Gene_locus related to this paper: drome-1vite , drome-2vite , drome-3vite , drome-a1z6g9 , drome-abhd2 , drome-ACHE , drome-b6idz4 , drome-BEM46 , drome-CG5707 , drome-CG5704 , drome-CG1309 , drome-CG1882 , drome-CG1986 , drome-CG2059 , drome-CG2493 , drome-CG2528 , drome-CG2772 , drome-CG3160 , drome-CG3344 , drome-CG3523 , drome-CG3524 , drome-CG3734 , drome-CG3739 , drome-CG3744 , drome-CG3841 , drome-CG4267 , drome-CG4382 , drome-CG4390 , drome-CG4572 , drome-CG4582 , drome-CG4851 , drome-CG4979 , drome-CG5068 , drome-CG5162 , drome-CG5355 , drome-CG5377 , drome-CG5397 , drome-CG5412 , drome-CG5665 , drome-CG5932 , drome-CG5966 , drome-CG6018 , drome-CG6113 , drome-CG6271 , drome-CG6283 , drome-CG6295 , drome-CG6296 , drome-CG6414 , drome-CG6431 , drome-CG6472 , drome-CG6567 , drome-CG6675 , drome-CG6753 , drome-CG6847 , drome-CG7329 , drome-CG7367 , drome-CG7529 , drome-CG7632 , drome-CG8058 , drome-CG8093 , drome-CG8233 , drome-CG8424 , drome-CG8425 , drome-CG9059 , drome-CG9186 , drome-CG9287 , drome-CG9289 , drome-CG9542 , drome-CG9858 , drome-CG9953 , drome-CG9966 , drome-CG10116 , drome-CG10163 , drome-CG10175 , drome-CG10339 , drome-CG10357 , drome-CG10982 , drome-CG11034 , drome-CG11055 , drome-CG11309 , drome-CG11319 , drome-CG11406 , drome-CG11598 , drome-CG11600 , drome-CG11608 , drome-CG11626 , drome-CG11935 , drome-CG12108 , drome-CG12869 , drome-CG13282 , drome-CG13562 , drome-CG13772 , drome-CG14034 , drome-nlg3 , drome-CG14717 , drome-CG15101 , drome-CG15102 , drome-CG15106 , drome-CG15111 , drome-CG15820 , drome-CG15821 , drome-CG15879 , drome-CG17097 , drome-CG17099 , drome-CG17101 , drome-CG17191 , drome-CG17192 , drome-CG17292 , drome-CG18258 , drome-CG18284 , drome-CG18301 , drome-CG18302 , drome-CG18493 , drome-CG18530 , drome-CG18641 , drome-CG18815 , drome-CG31089 , drome-CG31091 , drome-CG32333 , drome-CG32483 , drome-CG33174 , drome-dnlg1 , drome-este4 , drome-este6 , drome-GH02384 , drome-GH02439 , drome-glita , drome-KRAKEN , drome-lip1 , drome-LIP2 , drome-lip3 , drome-MESK2 , drome-nrtac , drome-OME , drome-q7k274 , drome-Q9VJN0 , drome-Q8IP31 , drome-q9vux3

Title : Purification and kinetic characterisation of juvenile hormone esterase from Drosophila melanogaster - Campbell_1998_Insect.Biochem.Mol.Biol_28_501
Author(s) : Campbell PM , Oakeshott JG , Healy MJ
Ref : Insect Biochemistry & Molecular Biology , 28 :501 , 1998
Abstract : Campbell_1998_Insect.Biochem.Mol.Biol_28_501
ESTHER : Campbell_1998_Insect.Biochem.Mol.Biol_28_501
PubMedSearch : Campbell_1998_Insect.Biochem.Mol.Biol_28_501
PubMedID: 9718682
Gene_locus related to this paper: drome-CG8425