drome-CG9542

 
Drosophila melanogaster (Fruit fly) kynurenine formamidase cg9542 protein (rh42281p)

Comment
Catalyzes the hydrolysis of N-formyl-L-kynurenine to L-kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Required for elimination of toxic metabolites.


Relationship
Block H
Drosophila melanogaster position in NCBI Life Tree :
N link to NCBI taxonomic web page and E link to ESTHER gene locus found in this strain.
> cellular organisms: N E > Eukaryota: N E > Opisthokonta: N E > Metazoa: N E > Eumetazoa: N E > Bilateria: N E > Protostomia: N E > Ecdysozoa: N E > Panarthropoda: N E > Arthropoda: N E > Mandibulata: N E > Pancrustacea: N E > Hexapoda: N E > Insecta: N E > Dicondylia: N E > Pterygota: N E > Neoptera: N E > Holometabola: N E > Diptera: N E > Brachycera: N E > Muscomorpha: N E > Eremoneura: N E > Cyclorrhapha: N E > Schizophora: N E > Acalyptratae: N E > Ephydroidea: N E > Drosophilidae: N E > Drosophilinae: N E > Drosophilini: N E > Drosophila [fruit fly, genus]: N E > Sophophora: N E > melanogaster group: N E > melanogaster subgroup: N E > Drosophila melanogaster: N E

Molecular evidence
Database
No mutation
3 structures: 4E15, 4E11, 4E14
No kinetic


Inhibitor: PMSF ,
3 Genbank : AE003613, AY089670, AE014134
1 UniProt : X2J8X6
3 Structure : 4E15, 4E11, 4E14
2 UniProtTrembl : Q9VMC9, X2J8X6
2 Interpro : Q9VMC9, X2J8X6
2 Prodom : Q9VMC9, X2J8X6
2 Pfam : Q9VMC9, X2J8X6
2 PIRSF : Q9VMC9, X2J8X6
2 SUPERFAM : Q9VMC9, X2J8X6
2 QuickSwissBlast : Q9VMC9, X2J8X6
1 FlyBase : 0031821
 
Sequence
Graphical view for this peptide sequence: drome-CG9542
Colored MSA for Kynurenine-formamidase (raw)
MYNPRCKDLDRDYFPSYHTTRFQDQPEPNLAVLEHFVRVTKQHGRELTEK
QGITVDHLRYGEGRQLVDVFYSEKTTNQAPLFVFVHGGYWQEMDMSMSCS
IVGPLVRRGYRVAVMDYNLCPQVTLEQLMTQFTHFLNWIFDYTEMTKVSS
LTFAGHSAGAHLLAQILMRPNVITAQRSKMVWALIFLCGVYDLRELSNLE
SVNPKNILGLNERNIESVSPMLWEYTDVTVWNSTKIYVVAAEHDSTTFIE
QSRHYADVLRKKGYKASFTLFKGYDHFDIIEETAIDDSDVSRFLRNIEIE
Legend This sequence has been compared to family alignement (MSA)
red => minority aminoacid
blue => majority aminoacid
color intensity => conservation rate
title => sequence position(MSA position)aminoacid rate
Catalytic site
Catalytic site in the MSA

MYNPRCKDLDRDYFPSYHTTRFQDQPEPNLAVLEHFVRVTKQHGRELTEK
QGITVDHLRYGEGRQLVDVFYSEKTTNQAPLFVFVHGGYWQEMDMSMSCS
IVGPLVRRGYRVAVMDYNLCPQVTLEQLMTQFTHFLNWIFDYTEMTKVSS
LTFAGHSAGAHLLAQILMRPNVITAQRSKMVWALIFLCGVYDLRELSNLE
SVNPKNILGLNERNIESVSPMLWEYTDVTVWNSTKIYVVAAEHDSTTFIE
QSRHYADVLRKKGYKASFTLFKGYDHFDIIEETAIDDSDVSRFLRNIEIE

no DNA




References
7 more
    Title: Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster euchromatic genome sequence
    Celniker SE, Wheeler DA, Kronmiller B, Carlson JW, Halpern A, Patel S, Adams M, Champe M, Dugan SP and Rubin GM <22 more author(s)>
    Ref: Genome Biol, 3:RESEARCH0079, 2002 : PubMed

            

    Title: Annotation of the Drosophila melanogaster euchromatic genome: a systematic review
    Misra S, Crosby MA, Mungall CJ, Matthews BB, Campbell KS, Hradecky P, Huang Y, Kaminker JS, Millburn GH and Lewis SE <20 more author(s)>
    Ref: Genome Biol, 3:RESEARCH0083, 2002 : PubMed

            

    Title: The genome sequence of Drosophila melanogaster
    Adams MD, Celniker SE, Holt RA, Evans CA, Gocayne JD, Amanatides PG, Scherer SE, Li PW, Hoskins RA and Venter JC <185 more author(s)>
    Ref: Science, 287:2185, 2000 : PubMed

            


Other Papers


Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
For technical information about these pages see:
ESTHER Home Page and ACEDB Home Page
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